ABSTRACT
A case of giant cell tumour of the pancreas with a mixture of pleomorphic giant cells and osteoclast-like cells is described. This association is rare and its histogenesis has been debated. The presence of a small differentiated adenocarcinomatous area at the periphery of the tumour indicates an epithelial origin. Moreover, some pleomorphic cells were positive for keratin (KL1). The osteoclast-like cells strongly expressed CD68 (a marker of histiomonocytic lineage) and did not show proliferative activity. They probably correspond to an unusual reaction of the stroma. Their clinical importance in this type of tumour remains unknown.
Subject(s)
Giant Cell Tumors/pathology , Osteoclasts/pathology , Pancreatic Neoplasms/pathology , Antigens, CD/analysis , Antigens, Differentiation, Myelomonocytic/analysis , Giant Cell Tumors/chemistry , Humans , Keratins/analysis , Male , Middle Aged , Osteoclasts/chemistryABSTRACT
Bleeding remains on of the most fearsome complications of duodenal ulcer disease. It is, as if H2 Blockers, while never curing the ulcer, were in fact promoting its most severe forms, i.e., posterior huge ulcers, the control of which has to be a gastric resection. On the basis of a short but consecutive serie of 10 patients, the authors plead in favor of the exclusion of the ulcer from the digestive tract, using the wheeling off procedure to close the duodenal stump.
