Inflammatory profile in depression and associated clinical and sociodemographic features in a Middle-Eastern North-African population.

BACKGROUND: Evidence of the presence of an inflammatory syndrome in depressive disorders has aroused great interest among researchers but results were heterogeneous and almost all previous studies involved patients from Europe or North America. The objectives of the current study were to determine the prevalence of biological inflammatory syndrome among patients with depression in a Middle-Eastern/North-African population and to examine the associated sociodemographic and clinical factors. METHODS: We conducted a cross-sectional descriptive and comparative study including 65 patients and 30 healthy controls. The patients had an untreated major depressive episode and no inflammatory medical conditions; they were recruited in the psychiatry outpatient clinic in Razi hospital - Tunisia over an eight-month period ranging from May to December 2012. We examined sociodemographic and clinical characteristics and both groups had an inflammatory balance including: high sensitive C-reactive protein, interleukin 6, serum protein electrophoresis, haptoglobin and orosomucoid. A standardized inflammatory protein profile for age and sex was performed. RESULTS: High sensitive C-reactive protein levels did not differ significantly between patients with depression and controls. The assay results of Interleukin 6 in our study showed higher values in patients with depression than in controls (p=0.024). Albumin was found to be increased in patients with depression (p<0.001). The dosage of the alpha-1-globulin including the orosomucoid and of the alpha-2-globulin including haptoglobin, showed that patients with depression had higher values than controls (p<0.001). The inflammatory protein profile (which consists of a synthesis of three inflammatory proteins: high sensitive C-reactive protein, haptoglobin and orosomucoϊd) showed a trend towards higher levels of inflammation among patients with depression than among controls. LIMITATIONS: The relatively small number of subjects decreased the statistical power and the cross-sectional setting does not allow us to draw any conclusions about cause-to-effect relationships. Although we tried to exclude people with current infections, a small percentage of subjects may have had subclinical infections. The Body Mass Index, a parameter that might affect the levels of the investigated inflammatory markers, was not measured. CONCLUSION: The existence of inflammation in depression has been proven by the results of four meta-analyses and over a hundred studies. However, the generalization of this finding is yet to be confirmed. It seems more likely that inflammation concerns a subgroup of patients with depression. Studies targeting this particular subgroup could provide new therapeutic approaches.

The role of the affective temperament in the treatment adherence in psychiatry.

INTRODUCTION: Adherence to psychotropic medications is affected by factors related to the treatment, to the physician, to the environment and to the patient himself. The purpose of the present study was to investigate the influence of affective temperaments on treatment adherence. METHODS: Thirty six stabilized outpatients were recruited from the aftercare consultation of Psychiatry to perform Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto questionnaire version (TEMPS-A) for affective temperaments and the Medication Adherence Rating Scale (MARS) for treatment adherence. RESULTS: The total MARS score was negatively correlated with the irritable temperament score. The MARS's score relative to the attitude of patients to psychotropic medications and their negative side effects was negatively correlated with the cyclothymic, the irritable and anxious temperaments. Patients having a diagnosis of psychotic disorder had a significantly greater medication adherence and behaviour toward medication score compared to those having a diagnosis of affective disorder. A greater MARS's score for the negative side effects and attitudes to psychotropic medication was associated with medication by neuroleptics with prolonged action. CONCLUSION: The results of the present study suggest that patients with irritable temperament may have more difficult to follow psychotropic medications, and that patients with cyclothymic, irritable and anxious temperaments may be more attentive and sensitive toward psychotropic medications and their negative side effects.

[A descriptive study of the procedures of psychiatric admissions at Razi hospital]. / Etude descriptive des modalités d'hospitalisation en psychiatrie á l'hôpital Razi.

BACKGROUND: The law 92-83, has established the rights of the mentally ill to respect for individual freedom and to appropriate care. However some gaps in its implementation led to the revision by Act 2004-40. AIM: To study the evolution of the number of admissions with and without consent (hospitalizations at the request of a third party and compulsory hospitalizations), between 2000 and 2009. METHODS: Retrospective study of the archives of the mental health unit of Razi hospital. The study population included inpatients under the mode of voluntary and involuntary admission either compulsory hospitalizations or at the request of a third party. RESULTS: An increase in the number of hospitalizations without the consent from 2000 to 2009 was noted. The number of compulsory hospitalizations and the one of hospitalizations at the request of a third party rose respectively from 1,048 to 1,443 and from 22 to 1,323. So the number of free hospitalizations has decreased while the number of involuntary hospitalizations has increased, leading to a constant number of total hospitalizations. The sex ratio for compulsory hospitalizations has increased from 2.04 to 5.83 while it markedly decreased for hospitalizations at the request of a third party (from 10 to 1.7).Men, unlike women, were more likely to be hospitalized compulsorily than at the request of a third party. CONCLUSION: There is a larger use of hospital admissions under constraints than free ones; is it due to a concern for the respect of law or an abuse in the deprivation of freedom for some patients?