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1.
RSC Adv ; 14(21): 15048-15057, 2024 May 02.
Article in English | MEDLINE | ID: mdl-38720969

ABSTRACT

This study investigates the impact of lithium doping on the structural and photophysical properties of spin-coated CsPbBr3 perovskite thin films. The deposited films display a pristine structure, preferentially growing along the (220) direction, and exhibit high-quality green photoluminescence at around 530 nm. The doping leads to an improvement in the optical properties of the films, as evidenced by a stronger photoluminescence (PL) intensity compared to undoped CsPbBr3, particularly at temperatures below 200 K. The increase in PL intensity suggests a decrease in defects and surface passivation. Additionally, the decrease in the power-law exponent ß from 1.6 to 1.0 indicates a reduction in non-radiative recombination, likely due to trap states filling with free electrons induced by the doping. Overall, doping with lithium reduces non-radiative recombination, fills trap states, and reduces band tail/activation energy, leading to improved optoelectronic properties of the films. This investigation provides insights into the photophysical properties of the Li-CsPbBr3 absorber layer and the recombination mechanism, and helps to unravel new methods for the development of high-stability, high-performance perovskite thin-film solar cells and optoelectronic devices.

2.
Heliyon ; 9(10): e20543, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37817990

ABSTRACT

The Gulf Cooperation Council (GCC) countries include Bahrain, Kuwait, Saudi Arabia, Sultanate of Oman, Qatar, and United Arab Emirates. The GCC countries are located in an arid region. They have limited renewable water resources due to scarcity of rainfall. This paper provides the most recent and accurate quantitative and qualitative assessment of available water resources and demands in the GCC countries. The annual renewable surface water, desalinated capacity, wastewater treatment capacity, and per capita water consumption in the GCC countries are assessed. The possible impacts of climate change are discussed. The annual renewable surface water, desalinated capacity, and wastewater treatment capacity in the GCC countries are estimated as 4.14, 26.4, and 10.07 billion m3, respectively. The average per capita water consumption is around 550 l/d. The GCC countries have high water footprints. Although tertiary treated, the reuse of treated wastewater is limited and constrained to the development of forests and green areas. Water demand trends reveal the need for the implementation of sustainable water management programs. Emerging solutions include imposing a new tariff system, improving irrigation efficiency, controlling agricultural water consumption, developing innovative desalination and treatment technologies, maximizing treated wastewater utilization and rainwater harvesting, eliminating leakage in networks, and considering virtual water concepts in the water budget and planning.

3.
Heliyon ; 9(3): e14584, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36967941

ABSTRACT

Clean water and sanitation and climate actions represent two of the seventeen United Nations Sustainable Development Goals (SDGs). Although challenging, the two goals can be achieved by 2030 through unconventional and innovative solutions. Scientific research related to clean water and sanitation (SDG 6) and urgent actions to combat climate change and its impacts (SDG 13) will help develop new technologies to support the two goals and can bridge the gap between practitioners and academia's to achieve sustainability. The Gulf Cooperation Council (GCC) countries are located in an arid region. Their water and climate research activities and outcomes may provide a good contribution toward achieving the two goals. This study used text mining and bibliometric methods to analyze water and climate research contributions to achieve SDGs 6 and 13 in GCC countries. Results revealed that there is an increase in research publications after 2016 in the areas of water and climate in the GCC countries involving a longstanding international collaboration with developed countries. Research topics were focused on wastewater treatment, contamination, heavy metal, groundwater, and climate change impacts. Under SDG 6, most of the publications were research articles (77.3%), followed by reviews (11.1%), and the rest were book chapters and conference papers. For SDG 13, 75.1% of the publications are research articles, 10.9% are conference papers, and 8% are reviews. The research outcomes in the GCC countries have clearly contributed to the development of water and climate strategies and international collaborations to achieve the two goals.

4.
J Ayub Med Coll Abbottabad ; 34(4): 830-833, 2022.
Article in English | MEDLINE | ID: mdl-36566408

ABSTRACT

BACKGROUND: Variceal bleeding is a key and most fatal complication observed in chronic liver disease patients with portal hypertension and is a major contributor to the high morbidity and mortality seen in these patients. Exploring the predictors of rebleeding in chronic liver disease patients is of paramount importance to alter disease course and impact on morbidity and mortality. METHODS: About 50 patients with chronic liver disease who previously had evidence of varices on upper GI endoscopy and had at least one episode of rebleeding after EVBL were included in this study. Patients were assessed for the possible contributors to rebleeding through complete history, clinical examination, coagulation profile and platelet count, ultrasound features (splenic size and portal pressure), and upper GI endoscopic findings (site and grade of varices, red sign). Sample selection was done using non-probability purposive sampling technique and sample size calculated using the standard WHO formula. Data was entered and analyzed using SPSS version 20. RESULTS: In this study, mean age of the patients was 51.34±6.34 years with male predominance (64%). Rebleeding was significantly associated with grade of varices, presence of red sign on upper GI endoscopy, site of varices, splenic size and coagulopathy. CONCLUSIONS: Rebleeding in chronic liver disease patients following EVBL is predicted by grade, extent and site of varices, red sign on upper GI endoscopy, splenic size and coagulation disturbances.


Subject(s)
Esophageal and Gastric Varices , Hypertension, Portal , Varicose Veins , Humans , Male , Middle Aged , Female , Esophageal and Gastric Varices/surgery , Esophageal and Gastric Varices/complications , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/diagnosis , Ligation/methods , Hypertension, Portal/complications
5.
PLoS One ; 17(10): e0275779, 2022.
Article in English | MEDLINE | ID: mdl-36227836

ABSTRACT

PURPOSE: The current study investigated the therapeutic potential of transcranial direct current stimulation (tDCS) on speech intelligibility, speech-related physiological and vocal functions among post-stroke dysarthric patients. METHOD: Nine chronic post-stroke dysarthric patients were randomly assigned to the stimulation or sham group. The stimulation group received 2mA of anodal tDCS over the left inferior primary motor cortex for 15 minutes, while the sham group received 30s of stimulation under the same settings. All the participants received 10 daily 15 minutes of individualized speech therapy targeting their dominant phonological process or phonemes with the greatest difficulty. The outcome measures included (1) perceptual analysis of single words, passage reading and diadochokinetic rate, (2) acoustic analysis of a sustained vowel, and (3) kinematic analysis of rapid syllable repetitions and syllable production in sentence, conducted before and after the treatment. RESULTS: The results revealed that both the stimulation and sham groups had improved perceptual speech intelligibility at the word level, reduced short rushes of speech during passage reading, improved rate during alternating motion rate, AMR-kha1, and improved articulatory kinematics in AMR-tha1 and syllables /tha1/ and /kha1/ production in sentence. Compared to the sham group, the stimulation group showed significant improvement in articulatory kinematics in AMR-kha1 and syllable /kha1/ production in sentence. The findings also showed that anodal stimulation led to reduced shimmer value in sustained vowel /a/ phonation, positive changes in articulatory kinematics in AMR-tha1 and syllables /pha1/ and /kha1/ production in sentence at the post treatment measure. In addition to positive effects on articulatory control, reduced perturbation of voice amplitude documented in the stimulation group post treatment suggests possible tDCS effects on the vocal function. CONCLUSIONS: The current study documented the beneficial effects of anodal tDCS over the primary motor cortex on speech production and suggested that combined tDCS and speech therapy may promote recovery from post-stroke dysarthria.


Subject(s)
Motor Cortex , Stroke , Transcranial Direct Current Stimulation , Humans , Pilot Projects , Speech Intelligibility , Stroke/complications , Stroke/therapy , Transcranial Direct Current Stimulation/methods
6.
Nanomaterials (Basel) ; 12(17)2022 Aug 31.
Article in English | MEDLINE | ID: mdl-36080064

ABSTRACT

Presently, we inquire about the organic/inorganic cation effect on different properties based on structure, morphology, and steadiness in preparing a one-step solution of APbI3 thin films, where A = MA, FA, Cs, using spin coating. This study was conducted to understand those properties well by incorporating device modeling using SCAPS-1D software and to upgrade their chemical composition. X-ray diffraction (XRD) was used to analyze the crystal structures. Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM) were conducted to characterize the surface morphology; photoluminescence, Transmission Electron Microscopy (TEM), and a UV-Visible spectrometer helped us to study the optical properties. The (110) plane is where we found the perovskite's crystalline structure. According to the XRD results and by changing the type of cation, we influence stabilization and the growth of the APbI3 absorber layer. Hither, a homogenous, smooth-surfaced, pinhole-free perovskite film and large grain size are results from the cesium cation. For the different cations, the band gap's range, revealed by the optical analysis, is from 1.4 to 1.8 eV. Moreover, the stability of CsPbI3 remains excellent for two weeks and in a ~60% humid environment. Based on the UV-Visible spectrometer and photoluminescence characterization, a numerical analysis for fabricated samples was also performed for stability analysis by modeling standard solar-cell structures HTL/APbI3/ETL. Modeling findings are in good agreement with experimental results that CsPbI3 is more stable, showing a loss % in PCE of 14.28%, which is smaller in comparison to FAPbI3 (44.46%) and MAPbI3 (20.24%).

7.
Future Healthc J ; 8(2): e293-e298, 2021 Jul.
Article in English | MEDLINE | ID: mdl-34286201

ABSTRACT

INTRODUCTION: The COVID-19 pandemic has challenged healthcare facilities and healthcare professionals' stamina and wellbeing. This study examines the psychological impact of COVID-19 on healthcare professionals. METHODS: This analytical cross-sectional study was conducted in July 2020 after institutional review board approval at a tertiary care institution in Lahore, Pakistan. A total of 175 healthcare workers participated following an online Depression, Anxiety and Stress Scale-21 (DASS-21) questionnaire invitation and 41 were excluded following pre-existing mental health conditions. Data was analysed using MS Excel and SPSS Amos 23. Chi-squared test and regression were applied for comparison and impact of confounding variables respectively (p<0.05 was considered significant). RESULTS: Out of 134, 66 (49%) were doctors, 24 (18%) were nurses and 44 (33%) were non-medical professionals. Ninety-five (70%) with age 21-30 years. Male to female ratio was 2:1. Overall mean depression score accounted for 6.89 ± 6.64; anxiety score was 7.28 ± 6.74 and stress score was 8.83 ± 6.93. Mild depression, anxiety and stress was noted in 21 (15.6%), eight (6%) and 27 (20.1%) healthcare workers, respectively. A statistically significant difference (p<0.05) was observed among healthcare workers for depression, anxiety and stress. CONCLUSION: This study demonstrated considerable impact of COVID-19 on mental health of healthcare workers. A well-structured targeted mental health support programme is needed urgently to support and reduce the long-term impact on healthcare workers' mental health and wellbeing.

9.
Cureus ; 12(12): e12039, 2020 Dec 12.
Article in English | MEDLINE | ID: mdl-33457138

ABSTRACT

Introduction Coronavirus disease 2019 (COVID-19) presents with a wide spectrum of symptoms, ranging from patients being asymptomatic to having life-threatening acute respiratory distress syndrome (ARDS). COVID-19 emerged as a pandemic and has led to multiple causalities worldwide. A better understanding of the clinical characteristics of the COVID-19 patients and their disease course will aid in better management of these patients and hence may positively impact their outcomes as well. Methodology This was a retrospective observational study conducted from April 15, 2020, to August 31, 2020, after gaining institutional review board approval at the University of Lahore Teaching Hospital, Lahore, Pakistan. A total of 47 patients with severe disease who had died due to COVID-19 during this period were enrolled by the consecutive method. Patients were evaluated for their epidemiological, biochemical, clinical, and radiological features. The modified Radiographic Assessment of Lung Edema (mRALE) score was used to calculate the extent of alveolar opacities and percentages of lung involvement in chest radiographs. Furthermore, patients' management plans were also evaluated. Data were analyzed using SPSS Statistics version 23 (IBM, Armonk, NY). Results The mean age of the patients was 61.53 ±13.35 years. The male-to-female ratio was 2:1, and the mean BMI was 28.05 ±3.52 kg/m2. Diabetes was the most prevalent comorbidity among the patients (32, 68.1%), followed by hypertension (six, 12.8%), ischemic heart disease (five, 10.6%), and chronic kidney disease (four, 8.5%) respectively. The predominant symptom observed among patients was cough (95%), followed by shortness of breath (93%), fever (63%), sputum (23%), and gastrointestinal symptoms (6.4%). The mean D-dimer was 1,567.13 ±1,903.77 ng/mL, mean ferritin was 1,730.34 ±1,382.35 ng/mL, mean C-reactive protein (CRP) was 202.59 ±104.97 mg/dl, and the mean neutrophil-to-lymphocyte ratio was 10.50 ±9.58. Bilateral lung involvement was seen among 40 (85.11%) patients whereas unilateral right lung involvement was reported in three (6.38%) and unilateral left lung involvement in four (8.51%) respectively. The mean mRALE score for bilateral lung involvement was 18.78 ±4.89. The mean area radiologically involved in bilateral lung fields was 72.12 ±18.45%, followed by unilateral right lung involvement of 67.87 ±15.97%, and unilateral left lung involvement of 61.38 ±17.95% in the cohort respectively. The most common type of radiological pathology was diffuse ground-glass opacities, which was observed in 18 (38%) patients. Most patients received antibiotics (39, 63.83%), while nine (19%) received tocilizumab, four (8.5%) had antiviral therapy, and three (6.4%) were given plasma treatment. All patients received glucocorticoids and anticoagulation. The most common cause of death was ARDS, which was observed in 12 (25.5%) patients. Conclusion This study significantly demonstrated that most cases were males above 50 years of age with chronic medical comorbidities of diabetes, hypertension, and ischemic heart disease. COVID-19 has a predilection for multisystem involvement leading to mortality. In addition, elevated D-dimer and neutrophil-to-lymphocyte ratio may be indicative of a poor prognosis. A combination of antimicrobials had no positive impact on the outcomes in this cohort. It is difficult to predict the efficacy of tocilizumab and remdesivir as only a few patients in the cohort received these drugs.

10.
J Ayub Med Coll Abbottabad ; 30(1): 54-57, 2018.
Article in English | MEDLINE | ID: mdl-29504330

ABSTRACT

BACKGROUND: Portal hypertension can lead to oesophageal varices (EV) and portal hypertensive gastropathy (PHG). The aim of this study is to determine the relationship between severity of Portal hypertensive gastropathy and size of oesophageal varices. METHODS: One hundred and ninety-five patients of hepatitis C positive chronic liver disease having oesophageal varices were assessed for severity of portal hypertensive gastropathy. RESULTS: Mild Portal Hypertensive Gastropathy was observed in 16 (8.2 %), moderate in 54 (27.7 %) and severe in 120 (61.6 %) patients. Grade 1 Oesophageal Varices were present in 79 (40.5%) patients, grade 2 in 44 (21.9%) patients, grade 3 in 62 (31.8%) and grade 4 in 10 (5.2%) patients. No significant correlation was observed between grades of gastropathy and size of varices. CONCLUSIONS: The frequency of portal hypertensive gastropathy was 97.5% in Hepatitis C positive cirrhotic patients having oesophageal varices. Severity of gastropathy is not related to the grade or size of oesophageal varices.


Subject(s)
Esophageal and Gastric Varices , Hepatitis C, Chronic , Hypertension, Portal , Stomach Diseases , Cohort Studies , Esophageal and Gastric Varices/complications , Esophageal and Gastric Varices/epidemiology , Esophageal and Gastric Varices/pathology , Hepatitis C, Chronic/complications , Hepatitis C, Chronic/epidemiology , Humans , Hypertension, Portal/complications , Hypertension, Portal/epidemiology , Liver Cirrhosis/complications , Liver Cirrhosis/epidemiology , Stomach Diseases/epidemiology , Stomach Diseases/etiology , Stomach Diseases/pathology
11.
Sci Rep ; 7(1): 14350, 2017 10 30.
Article in English | MEDLINE | ID: mdl-29084994

ABSTRACT

Color Doppler vascular index (VI) was assessed alone and in combination with grey-scale ultrasound (GSU) in regionally subdivided thyroid nodules in diagnosing thyroid cancer. Color Doppler sonograms of 111 thyroid nodules were evaluated by a home-developed algorithm that performed "offsetting" (algorithm for changing the area of a region of interest, ROI, without distorting the ROI's contour) and assessed peripheral, central and overall VI of thyroid nodules. Results showed that the optimum offset for dividing peripheral and central regions of nodule was 22%. At the optimum offset, the mean VI of peripheral, central, and overall regions of malignant nodules were significantly higher than those of benign nodules (26.5 ± 16.2%, 21.7 ± 19.6%, 23.8 ± 4.6% v/s 18.2 ± 16.7%, 11.9 ± 15.1% and 16.6 ± 1.8% respectively, P < 0.05). The optimum cut-off of peripheral, central, and overall VI was 19.7%, 9.1% and 20.2% respectively. When compared to GSU alone, combination of VI assessment with GSU evaluation of thyroid nodules increased the diagnostic accuracy from 58.6% to 79.3% (P < 0.05). In conclusion, a novel algorithm for regional subdivision and quantification of thyroid nodular VI in ultrasound images was established, and the optimum offset and cut-off were derived. Assessment of intranodular VI in conjunction with GSU can increase the accuracy in ultrasound diagnosis of thyroid cancer.


Subject(s)
Thyroid Nodule/blood supply , Thyroid Nodule/diagnostic imaging , Thyroid Nodule/pathology , Adult , Algorithms , Decision Making, Computer-Assisted , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Neovascularization, Pathologic/diagnostic imaging , Sensitivity and Specificity , Thyroid Neoplasms/pathology , Ultrasonography/methods , Ultrasonography, Doppler, Color/methods
12.
Aging (Albany NY) ; 8(7): 1540-70, 2016 07.
Article in English | MEDLINE | ID: mdl-27425845

ABSTRACT

Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development yet achieves normal size at birth. To understand the differential requirements of distinct brain regions for Cyclin A2, we utilized neuroanatomical, transgenic mouse, and mathematical modeling techniques to generate testable hypotheses that provide insight into how Cyclin A2 loss results in compensatory forebrain growth during late embryonic development. Using unbiased measurements of the forebrain stem cell niche, we parameterized a mathematical model whereby logistic growth instructs progenitor cells as to the cell-types of their progeny. Our data was consistent with prior findings that progenitors proliferate along an auto-inhibitory growth curve. The growth retardation inCCNA2-null brains corresponded to cell cycle lengthening, imposing a developmental delay. We hypothesized that Cyclin A2 regulates DNA repair and that CCNA2-null progenitors thus experienced lengthened cell cycle. We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.


Subject(s)
Aging/physiology , Brain/metabolism , Cell Cycle/genetics , Cyclin A2/metabolism , Neurons/metabolism , Animals , Behavior, Animal/physiology , Conditioning, Psychological/physiology , Cyclin A2/genetics , DNA Repair , Hand Strength/physiology , Mice , Mice, Transgenic , Models, Biological , Motor Skills/physiology , Social Behavior , Stem Cell Niche
13.
J Comp Neurol ; 524(6): 1259-69, 2016 Apr 15.
Article in English | MEDLINE | ID: mdl-26400711

ABSTRACT

The postnatal period in mammals represents a developmental epoch of significant change in the autonomic nervous system (ANS). This study focuses on postnatal development of the area postrema, a crucial ANS structure that regulates temperature, breathing, and satiety, among other activities. We find that the human area postrema undergoes significant developmental changes during postnatal development. To characterize these changes further, we used transgenic mouse reagents to delineate neuronal circuitry. We discovered that, although a well-formed ANS scaffold exists early in embryonic development, the area postrema shows a delayed maturation. Specifically, postnatal days 0-7 in mice show no significant change in area postrema volume or synaptic input from PHOX2B-derived neurons. In contrast, postnatal days 7-20 show a significant increase in volume and synaptic input from PHOX2B-derived neurons. We conclude that key ANS structures show unexpected dynamic developmental changes during postnatal development. These data provide a basis for understanding ANS dysfunction and disease predisposition in premature and postnatal humans.


Subject(s)
Area Postrema/growth & development , Nerve Net/growth & development , Animals , Animals, Newborn , Area Postrema/chemistry , Female , Humans , Infant, Newborn , Male , Mice , Mice, 129 Strain , Mice, Inbred C57BL , Mice, Transgenic , Nerve Net/chemistry , Species Specificity
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