Vascular access strategy for delivering long-term antimicrobials to patients with infective endocarditis: device type, risk of infection and mortality.

BACKGROUND: This paper reports the use of different vascular access devices and the incidence of intravascular catheter-related infection (CRI) in patients receiving intravenous antibiotics for infective endocarditis (IE). AIM: To examine whether rates of infection vary with type of vascular access device, and assess the impact of CRI on mortality in IE. METHODS: A prospective observational service evaluation of all inpatients who received intravenous antibiotics for IE was performed. In total, 114 inpatients were evaluated. All cases of CRI [including exit-site infection, intravascular catheter-related bloodstream infection (CRBSI) and mortality] were recorded. Tunnelled and non-tunnelled central venous catheters (CVCs), and peripherally inserted cannulae were used for antibiotic delivery. FINDINGS: There were 15 episodes of CRI, 11 of which were CRBSI (all associated with CVC use). The remainder comprised uncomplicated exit-site infections. Use of tunnelled CVCs [hazard ratio (HR) 16.95, 95% confidence interval (CI) 2.13-134.93; P = 0.007] and non-tunnelled CVCs (HR 24.54, 95% CI 2.83-212.55; P = 0.004) was associated with a significantly increased risk of CRI. Risk of mortality increased significantly with Staphylococcus aureus as the cause of IE (P < 0.001) and CRBSI (P = 0.034). CONCLUSION: Risk of CRI in patients with IE is linked to the type of vascular access device used. Rates of CRBSI were greatest with CVCs, while peripheral venous cannulae were not associated with CRBSI or serious sequelae. Many patients (40%) tolerated complete treatment courses delivered via peripheral cannulae. These findings confirm the importance of device selection in reducing the risk of CRI; a potentially modifiable variable that impacts on outcome and mortality in IE.

Epididymal and prostatic histoplasmosis in a renal transplant recipient from southern India.

An unusual case of epididymal and prostatic histoplasmosis is reported from Karnataka State of southern India, in a 37-year-old male renal transplant recipient, who had presented with gastrointestinal histoplasmosis a year before the second presentation and had responded successfully to 9 months' treatment with itraconazole. The patient presented a second time with high-grade fever and pain in the scrotum and the lower abdomen. Ultrasound of the abdomen revealed a retrotrigonal abscess, which was confirmed on computed tomography scan of the pelvis. Pus was drained via transrectal route and biopsy specimens were taken from the epididymis and the prostate. Histopathology revealed the picture suggestive of histoplasmosis, and the pus on culture confirmed the infection with Histoplasma capsulatum. To our knowledge, only 5 cases of epididymal histoplasmosis have been reported in the literature, our case being the second report from India and sixth in the world; prostatic histoplasmosis is also a rare occurrence.

Viper bite causing an isolated lower motor neuron-type of facial palsy.

We describe an unusual case of viper (Daboia russelii) bite in a 48-year-old man from the state of Karnataka in southern India. He presented in a hypotensive state with a left lower motor neuron-type of facial palsy, necrosis at the site of the bite and acute renal failure. His laboratory parameters revealed renal failure and deranged coagulation parameters. He was treated with intravenous antibiotics and polyvalent antiserum venom, and dialysed in view of the renal failure. His renal function and coagulation abnormalities improved, and the facial palsy recovered with the treatment. The snake bite located away from the face, the facial palsy occurring a few hours after the venom injection and the rapid recovery following antivenin administration, support that the palsy was a direct result of systemic envenomation. To the best of our knowledge, an isolated lower motor neuron-type of facial palsy as a manifestation of systemic toxicity of a viper bite, has not been previously reported.