ABSTRACT
Baylisascaris procyonis roundworms can cause potentially fatal neural larva migrans in many species, including humans. However, the clinical spectrum of baylisascariasis is not completely understood. We tested 347 asymptomatic adult wildlife rehabilitators for B. procyonis antibodies; 24 were positive, suggesting that subclinical baylisascariasis is occurring among this population.
Subject(s)
Animals, Wild , Ascaridida Infections/epidemiology , Ascaridida Infections/transmission , Ascaridoidea , Zoonoses , Animals , Antibodies, Protozoan/blood , Antibodies, Protozoan/immunology , Ascaridida Infections/history , Ascaridida Infections/parasitology , Ascaridoidea/immunology , Canada/epidemiology , Female , Geography, Medical , History, 21st Century , Humans , Immunoglobulin G/blood , Immunoglobulin G/immunology , Male , Seroepidemiologic Studies , United States/epidemiologyABSTRACT
Field isolates of Phoma macrostoma were obtained from diseased Canada thistle growing in several geographically diverse regions. Bleaching and chlorotic symptoms were present on the infected plants. The isolates grown in liquid culture were found to produce phytotoxic metabolites which also caused bleaching when applied foliarly to several broadleaf species. Bioassay-directed isolation led to the discovery of macrocidins A and B, the first representatives of a new family of cyclic tetramic acids. This new chemotype may offer significant potential as a template for herbicide design.
