ABSTRACT
Spermatogonial X-irradiation with 0, 400 or 600 R in adult rats and 200 R in fetal rats was carried out to assess genetic damage by the test of induced dominant lethality. From postimplantation embryonic losses observed, dominant lethal rates were established to be significantly raised by a dose of 400 or 600 R. With 200 R given either to adult or to fetal rats, no excess was detected in embryonic death rates.
Subject(s)
Radiation Genetics , Spermatogonia/radiation effects , Spermatozoa/radiation effects , Animals , Genes, Dominant , Genes, Lethal , Infertility, Male/etiology , Male , Radiation Dosage , RatsABSTRACT
It has been demonstrated that Adeturon (S-2-aminoethyl-iso-thiuronium adenosine triphosphate) showed a marked protective effect against translocations induction in mice germ cells after chronic gamma-or neutron-irradiation.
Subject(s)
Adenosine Triphosphate/analogs & derivatives , Chromosome Aberrations/drug effects , Isothiuronium/analogs & derivatives , Radiation Effects , Radiation-Protective Agents/pharmacology , Spermatocytes/radiation effects , Spermatozoa/radiation effects , Thiourea/analogs & derivatives , Translocation, Genetic/drug effects , Adenosine Triphosphate/pharmacology , Animals , Gamma Rays , Isothiuronium/pharmacology , Male , Mice , Mice, Inbred C57BL , Neutrons , Spermatocytes/drug effects , beta-Aminoethyl Isothiourea/analogs & derivativesABSTRACT
Adult male mice were given a range of neutron doses at 80 +/- 20 mrad/h from a plutonium-beryllium source. Cytogenetic analysis indicated that chronic spermatogonial exposure to a mean total dose of 10, 30, 52, 98 or 150 rad produced translocations, sampled in spermatocytes four months later, amounting to 0.32, 0.99. 1.69, 1.91 and 1.65%, respectively. The dose response for the 0-52 rad range was linear. For higher doses, a better fit to the data was an expression with dose exponent above unity.
