ABSTRACT
BACKGROUND AND AIM: Since renalase is mostly expressed in kidney tubules, simple renal cyst (SRC) originates from the kidney tubules, and both conditions are related to hypertension, it may be possible that SRC is associated with increased renalase levels. Therefore, in the current study we aimed to confirm the relation between renalase and epinephrine levels, the association between SRC and renalase levels and the association between renalase, blood pressure levels and endothelial dysfunction. MATERIALS AND METHODS: We made a cross-sectional study including 75 patients with SRC, and 51 controls were included to the study. Flow-mediated dilatation (FMD) was assessed, and serum renalase and epinephrine levels were determined. RESULTS: Patient with SRC had lower renalase, higher epinephrine and lower FMD levels when compared to patients without SRC (p < 0.05). Log renalase was correlated with log epinephrine (r = -0.302, p = 0.001) and log FMD (r = 0.642, p < 0.0001). There was no correlation between renalase and urine albumin/creatinine ratio and glomerular filtration rate. In univariate analysis, age, glomerular filtration rate, renalase and FMD were associated with the presence of SRC. Multivariate regression analysis of factors which are statistically significant in univariate analysis showed that age and renalase was associated with the presence of SRC. CONCLUSION: We have demonstrated that renalase levels were associated with the presence of SRC and endothelial dysfunction. Further research is necessary to highlight underlying mechanisms.
Subject(s)
Epinephrine/blood , Hypertension , Kidney Diseases, Cystic , Kidney Tubules , Monoamine Oxidase/blood , Vasodilation/physiology , Adult , Creatinine/blood , Cross-Sectional Studies , Female , Glomerular Filtration Rate , Humans , Hypertension/blood , Hypertension/complications , Hypertension/diagnosis , Hypertension/physiopathology , Kidney Diseases, Cystic/blood , Kidney Diseases, Cystic/complications , Kidney Diseases, Cystic/diagnosis , Kidney Diseases, Cystic/physiopathology , Kidney Function Tests/methods , Kidney Tubules/diagnostic imaging , Kidney Tubules/metabolism , Kidney Tubules/physiopathology , Male , Middle Aged , Statistics as Topic , UltrasonographyABSTRACT
A 2 to 11% of the patients with acute cholecystitis that will develop gallbladder perforation and massive intraperitoneal hemorrhage as a result of perforation will rarely be seen. Massive intraperitoneal hemorrhage associated with the transhepatic perforation is very uncommon. By this article, we anticipate presenting clinical and radiological findings in a case that has acute cholecystitis with massive intraperitoneal hemorrhage associated with transhepatic perforation.
