ABSTRACT
The main functional characteristics of the left ventricle (LV) were defined using a method of multiphase radiopaque left ventriculography. Three groups of indices of LV function (energetic LV indices, indices of chamber diastolic function, and indices of local motion of the LV walls in the course of a complete cardiocycle) were standardized in healthy persons. An original algorithm of analysis of local LV myocardial contractility was used. A combined approach to interpretation of results of this method was worked out. A standard set of indices, reflecting LV function, was defined. Standardized values of these indices, necessary for an effective use of this method, were obtained.
Subject(s)
Diatrizoate Meglumine , Gated Blood-Pool Imaging , Ventricular Function, Left/physiology , Adult , Female , Humans , Male , Middle Aged , Reference ValuesSubject(s)
Coronary Circulation/drug effects , Coronary Vessels/drug effects , Myocardial Infarction/drug therapy , Streptokinase/therapeutic use , Thrombolytic Therapy , Ventricular Function, Left/drug effects , Age Factors , Aged , Coronary Circulation/physiology , Coronary Vessels/physiopathology , Female , Humans , Male , Middle Aged , Myocardial Infarction/physiopathology , Ventricular Function, Left/physiologyABSTRACT
The effect of Ritmilen and allapinin, a new Soviet antiarrhythmic drug, on hemodynamics and myocardial contractility were evaluated in 36 patients with various heart rhythm disorders during diagnostic coronary angiography. Ritmilen has been shown to have an essential cardiodepressive effect. An intravenous 150 mg dose of Ritmilen results in a depression of dp/dtmax, Veragut's index, ejection fraction, mean standard circular fibre shortening rate, and increase in left ventricular systolic and end diastolic pressure, total peripheral resistance and mean arterial blood pressure. Allapinin (30 mg) has no marked cardiodepressive effect, as compared to Ritmilen.
Subject(s)
Aconitine/analogs & derivatives , Anti-Arrhythmia Agents/therapeutic use , Arrhythmias, Cardiac/drug therapy , Disopyramide/therapeutic use , Hemodynamics/drug effects , Myocardial Contraction/drug effects , Adult , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/physiopathology , Depression, Chemical , Drug Evaluation , Female , Humans , Male , Middle AgedABSTRACT
A patient aged 42 with the aortic valve prosthesis was examined with the help of coronography and ultrasonic scanning of the heart in the period of ischemic injury of the anterior myocardium: occlusion of the unchanged anterior descending artery by an embolus formed on the artificial cardiac valve was revealed. Despite rapid recovery of arterial permeability (3 h 47 min, after the onset of disease) by intracoronary administration of streptase with subsequent anticoagulant and antiplatelet drug therapy the patient developed anterior myocardial infarction with left ventricular aneurysm and intracardiac thrombosis.
