ABSTRACT
Acrylamide is oxidized by cytochrome P450 2E1 (CYP2E1) to its epoxide form, glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activities. This study was carried out to investigate the early changes that may be related to the carcinogenic activity of acrylamide in thyroid, adrenal glands and testis in male rats. Forty adult Sprague Dawley male rats were divided equally into four groups, rats of Group I served as control, and rats of Groups II, III and IV were treated orally with acrylamide with doses 5, 10, 15 mg/kg/day body weight for 8 weeks. The results indicated that the plasma carcino embryonic antigen (CEA) and malondialdehyde (MDA) levels are higher, but free and total testosterone, triiodothyronine (T(3)) and thyroxine, or 3,5,3',5'-tetraiodothyronine (T(4)) and corticosterone levels are lower in rats treated with acrylamide than that in control rats. This study provides evidence of endocrine disturbance to the testis, thyroid and adrenal glands, which are also the organs in which acrylamide has been shown to cause tumors in experimental animals.
