ABSTRACT
We report a general design strategy for creating polymeric materials that are capable of providing global, macroscopic changes in their properties in response to specific local and fleeting stimuli. In a proof-of-concept demonstration, a single polymer is used, yet it enables selective responses to specific stimuli, and then internally drives a macroscopic change in the material (even in locations not exposed to the stimulus), where the magnitude of change is independent of the intensity of the applied stimulus.
Subject(s)
Atrial Appendage , Atrial Fibrillation/surgery , Heart Diseases/etiology , Thrombosis/etiology , Aged , Atrial Fibrillation/physiopathology , Echocardiography, Doppler, Color , Echocardiography, Transesophageal , Follow-Up Studies , Heart Diseases/diagnosis , Humans , Ligation/adverse effects , Male , Postoperative Complications , Thrombosis/diagnosisABSTRACT
This paper describes an efficient and high throughput method for fabricating three-dimensional (3D) paper-based microfluidic devices. The method avoids tedious alignment and assembly steps and eliminates a major bottleneck that has hindered the development of these types of devices. A single researcher now can prepare hundreds of devices within 1 h.
ABSTRACT
This article describes a small molecule reagent that is capable of detecting fluoride down to 0.12 mM (2.3 ppm) in water. The reagent reveals this level of fluoride through a novel autoinductive signal amplification reaction that produces an unambiguous colorimetric readout.
Subject(s)
Colorimetry/methods , Fluorides/analysis , Aniline Compounds/chemistry , Benzaldehydes/chemistry , Molecular StructureABSTRACT
A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.