Medication status and dual-tasking on turning strategies in Parkinson disease.

BACKGROUND: Parkinson disease (PD) patients have turning impairments that may increase fall risk. Clinics lack specialized kinematic equipment used in gait and turn analysis and require a simple method to evaluate fall risk and advise patients in turning strategy selection. OBJECTIVES: To enhance understanding of PD turning strategies and determine if turning can be assessed using a video-recording and categorization method, we compared 180-degree and 90-degree turns as a function of medication status and dual-tasking (DT). METHODS: 21 PD participants (H&Y stage 1-3) in PD-ON and PD-OFF medication states and 16 controls completed 180-degree and 90-degree turn-tasks with and without DT. Video-recordings of tasks permitted classification of 180-degree turns into Few-Step turns (FST) vs. Multi-Step turns (MST) and 90-degree turns into Step vs. Spin-turns. FST were further sub-classified into Twisting vs. Sideways turns and MST into Backward, Festination, Forward or Wheeling turns. Percentages of subtypes were analyzed across groups by task. RESULTS: IN 180-degree tasks, there was an effect of group: FST vs. MST F(2,55) = 9.578, p < .001. PD participants in the off-medication state (PD-OFF) produced significantly more MST with a larger number of different turning subtypes vs. controls or PD on medication (PD-ON). In 90-degree tasks, controls significantly increased their proportion of Step-turns while DT (p < .001), an adaptation not observed in PD-ON or PD-OFF. CONCLUSIONS: PD turning impairments may stem from an inability to select a unified turning strategy and to adapt to the turning environment, which may be exacerbated in PD-OFF. Video-analysis may prove beneficial in predicting a clinical course for PD patients by revealing features of turning dysfunction.

Radially and azimuthally polarized nanosecond Yb-doped fiber MOPA system incorporating temporal shaping.

We report an Yb-doped fiber master-oscillator power-amplifier (MOPA) system with the capability of selectively generating doughnut-shaped radially and azimuthally polarized beams with user-defined temporal pulse shapes. The desired output polarization was generated with the aid of a nanograting spatially variant half-waveplate (S-waveplate). The latter was used to convert the linearly polarized fundamental (LP01) mode output from the preamplification stages to a doughnut-shaped radially polarized beam prior to the power amplifier stage. A maximum output pulse energy of ∼860 µJ was achieved for ∼100 ns pulses at 25 kHz with user-defined pulse shape for both radial and azimuthal polarization states. The polarization purity and beam propagation factor (M2) were measured to be >12 dB and 2.2, respectively.