ABSTRACT
Addition of perfluorodecalin with gas-transporting function to the liquid medium during submerged cultivation of actinomycetes of the genus Streptomyces resulted in higher intensity and level of the biomass synthesis and increased production of streptomycin and daunorubicin. Addition of perfluorodecalin to the medium provided a 2.0-2.3-fold surpass of the maximum antibiotic production (achieved by the 120th-144th hours of the culture growth) vs. the antibiotic accumulation peaks in the control.
Subject(s)
Anti-Bacterial Agents/biosynthesis , Daunorubicin/biosynthesis , Fluorocarbons/pharmacology , Streptomyces griseus/drug effects , Streptomyces/drug effects , Streptomycin/biosynthesis , Biomass , Bioreactors , Culture Media/chemistry , Fermentation , Fluorocarbons/metabolism , Streptomyces/growth & development , Streptomyces/metabolism , Streptomyces griseus/growth & development , Streptomyces griseus/metabolismABSTRACT
The publication is concerned with development of the technological processes for submered production of the first domestic antibiotics 70 years age. The literature data on the contribution of the microbiologists of the Kirov City and mainly the workers of the Red Army Research Institute of Epidemiology and Hygiene (nowadays Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Kirov), to development of the manufacture processes for production of penicillin and streptomycin are reviewed.