[The excretion of intrasystemic regulators of granulocytopoiesis and the causes producing its alteration]. / Ekskretsiia vnutrisistemnykh reguliatorov granulotsitopoéza i prichiny, vyzyvaiushchie ee izmeneniia.

Changes in the excretion of tissue-specific inhibitor and myelopoiesis stimulator (chalone and antichalone) by the mature neutrophils in respect to intracellular concentration interactions and the presence of products of autologous cells splitting, were studied on the models in vivo and in vitro.

[The role of granulocytic chalone and antichalone in regulating granulocytopoiesis under stress]. / Rol' granulotsitarnogo keilona i antikeilona v reguliatsii granulotsitopoéza pri stresse.

The experiments on rats have shown that immobilization stress induces a prolonged increase of the activity in the blood serum of tissue-specific granulocytopoiesis stimulator--granulocytic antichalone.

[The chalone-antichalone system, and mechanisms regulating granulocytopoiesis]. / Keilonno-antikeilonnaia sistema i mekhanizmy reguliatsii granulotsitopoéza.

The normal physiological balance between granylocytic chalone and antichalone is shown to be significantly upset where an inflammatory focus is present, with segmented neutrophils activated by cell breakdown products producing, for the most part, a stimulator of cell proliferation. It is also shown that the production of tissue-specific regulators in inflammation depends on the functional state of the entire mature neutrophil pool. The mechanisms of intrasystemic granulocytopoiesis regulation have been unraveled.

[Variants of chronic heart failure in ischemic heart disease patients and optimization of their treatment]. / Varianty khronicheskoi serdechnoi nedostatochnosti u bol'nykh ishemicheskoi bolezn'iu serdtsa i optimizatsiia ikh lecheniia.

Computer-assisted classification of hemodynamic data was performed in 172 patients with coronary heart disease aggravated by chronic heart failure. Six groups of patients have been identified, and an individual treatment algorithm has been proposed for each of those. The use of optimum individual treatment schedules has produced good or satisfactory clinical effect in 87.3%.

[Results of automatic screening for ischemic heart disease and arterial hypertension among the rural population]. / Rezul'taty avtomatizirovannogo vyiavleniia ishemicheskoi bolezni serdtsa i arterial'noi gipertonii sredi sel'skogo naseleniia.

The results of automated screening for coronary disease and arterial hypertension within large-scale preventive checkups of rural populations are reported. A system was developed, on the basis of Rose's questionnaire and the Minnesota Code, for the assessment of resting ECG, using a remote-control advisory panel and new mini-computers of domestic manufacture. A total of 6133 residents from several districts were examined. The efficiency and quality of the operation of the automated screening system was assessed. The use of automated data collection and analysis in conditions of large-scale preventive checkups was shown to be an important contribution towards the objective of universal preventive medical examinations of the population, rural population in particular.

[Use of an additionally intensified ECG in diagnosing ischemic heart disease]. / Primenenie dopolnitel'no usilennoi EKG v diagnostike ishemicheskoi bolezni serdtsa.

The article deals with the use of the additionally intensified ECG while conducting the bicycle ergometric test in 92 patients with coronary heart disease. It has been shown that when additionally intensified ECG is combined with bicycle ergometry the use of such parameters as the value of ST segment depression and the average rate of ST integral increases the resolving capacity of the technique. In patients with a positive result of the test according to the criterion of ST segment depression (0.1 mV or more), the ischemic changes on the additionally intensified ECG are determined one grade earlier than the threshold exercise and precede the anginal attack. In patients with an anginal attack without diagnostically significant changes on the ECG during 1 mV = 10 mm intensification, the employment of additionally intensified ECG makes it possible to identify the ischemic changes and confirm the pain attack by objective findings.

[Measurement of peripheral venous pressure using Doppler ultrasound]. / Izmerenie davleniia v perifericheskikh venakh s ispol'zovaniem ul'trazvukovogo dopplerovskogo metoda.

A method for determining peripheral venous pressure in the cubital vein by means of dopplerography is described. Fifty-four subjects (12 normal subjects, 19 hypertensive patients and 23 coronary patients) have been investigated. Patients with cardiovascular diseases showed somewhat increased peripheral venous pressure. The method is simple, non-invasive, it permits continuous monitoring of pressure in a major, easily-accessible vein and is not time-consuming.