Clinical Evaluation Versus Undetectable High-Sensitivity Troponin for Assessment of Patients With Acute Chest Pain.

Decision-making in acute chest pain remains challenging despite normal (below ninety-ninth percentile) high-sensitivity troponin (hs-cTn). Some studies suggest that undetectable hs-cTn, far below the ninety-ninth percentile, might rule out acute coronary syndrome. We investigated clinical data in comparison to undetectable hs-cTnT. The study comprised 682 patients (November 2010 to September 2011) presenting at the emergency department with chest pain and normal hs-cTnT (<14 ng/l). The main end point was major adverse cardiac events (MACE: death, myocardial infarction, readmission for unstable angina, or revascularization) at a 4-year median follow-up; secondary end point was 30-day MACE. A clinical score was built by assigning points according to hazard ratios of the independent predictive variables: 1 point (male and effort-related pain) and 2 points (recurrent pain and prior ischemic heart disease). The negative predictive values of the clinical score and undetectable hs-cTnT (<5 ng/l), were tested. A total of 72 (10.6%) patients suffered long-term MACE. The C-statistics of the clinical score for long-term (0.75) and 30-day (0.88) MACE were higher than with the TIMI(Thrombolysis In Myocardial Infarction) risk (0.68, 0.77) or GRACE(Global Registry of Acute Coronary Events) (0.50, 0.47) scores. Likewise, the negative predictive values of score = 0 (97.5%, 100%) and ≤1 point (95.9%, 100%) were higher than using undetectable hs-cTnT (91.9%, 98.1%). Both clinical scores of 0 and ≤1 better classified patients at risk of MACE (p = 0.0001, log-rank test) than hs-cTnT <5 ng/l (p = 0.06). In conclusion, clinical data can guide decision-making and perform at least equally well as undetectable hs-cTnT, in patients presenting at the emergency department with chest pain and normal hs-cTnT.

Long-term survival rates of implants supporting overdentures.

The study aims were to evaluate survival rates of dental implants in patients wearing maxillary and mandibular overdentures in relation to age, sex, smoking, implant splinting or non-splinting, the maxilla rehabilitated, and number of implants per dental arch. This was a prospective study of patients who were completely edentulous in either mandible or maxilla or both, rehabilitated with implant-retained overdentures, with a follow-up of at least 3 years. 95 patients with 107 overdentures were supported by 360 implants were included in the study. Rehabilitations were monitored over an average of 95 ± 20.3 months (range 36-159). Implant survival in the maxilla was 91.9% and in the mandible 98.6%, representing a statistically significant difference (P < .05). Age, sex and implant splinting did not influence survival rates significantly. Smokers presented a lower survival rate. Implant numbers in the maxilla had a significant influence on survival, 100% for 6 but 85.7% for 4. Three mandibular implants achieved higher survival rates (100%) but with 2 (96.6%) or 4 (99%) survival was lower, although without significant difference. Long-term results suggest that 3-implant mandibular overdentures have an equivalent survival rate to 4-implant overdentures. In the maxilla, results showed that 6 implants may be the best treatment strategy. For smokers with fewer implants retaining the overdentures, there were higher numbers of implant failures.

Correcting loss of a papilla following orthodontic space opening (Atherton´s patch) through implant supported rehabilitation. A case report.

The objective of this case report is to describe a surgical and prosthetic technique to create a lost papilla following orthodontic space opening (Atherton´s patch) through implant supported rehabilitation. A switching platform implant was used to replace a left maxillary canine in a unitary interdental edentulous ridge with Atherton´s patch in the distal area of the upper lateral left incisor. The radiographic study revealed correct level of the interproximal bone of the adjacent teeth. A mucoperiosteal flap with crest incision and sulcular extension to the adjacent teeth was made. Special attention was paid to correct position of the implant and the distance (≥ 1.5 mm) between the platform and the roots of the adjacent teeth. A submerged technique was used. Tissue modeling through provisional crown was performed in order to create an ideal emergence profile with total papilla fill recorded at the Atherton´s patch area. Final screw retained CAD-CAM zirconia structure was place. Final follow up was performed 2 years after provisional crown placement, and total fill of both papilla, including at Atherton´s patch area, was recorded. Key words:Atherton´s patch, papilla, switching platform, implant and orthodontics, esthetic score.

Using high-sensitivity troponin T: the importance of the proper gold standard.

OBJECTIVE: The study objective was to determine how best to use high-sensitivity cardiac troponin T (hscTnT) to diagnose myocardial infarction. METHODS: A total of 358 patients presenting with acute coronary syndromes sampled at admission and 2, 4, and 6 to 8 hours. Both contemporary cardiac troponin T (cTnT) and hscTnT were measured. Patients were classified with conventional cTnT values by independent investigators. Myocardial infarction required a cTnT value ≥99th reference percentile and a ≥20% change. RESULTS: Seventy-nine patients had non-ST-segment elevation myocardial infarction, 105 patients had unstable angina, and 174 patients had nonacute coronary syndromes. A cTnT cutoff at the 10% coefficient of variation value missed 14.5% of infarctions. hscTnT had a sensitivity at admission of 89.9%, but specificity was only 75.1% because of elevations in 45.3% and 25.3% of those with unstable angina and nonacute coronary syndromes, respectively. The optimal value for myocardial infarction diagnosis with hscTnT was 25 ng/L at admission and 30 ng/L during serial sampling. All infarctions were diagnosed within 4 hours, with a time saving of 11 and 68 minutes compared with a cTnT value at the 99th reference percentile value and a cTnT value at a coefficient of variation of 10%. By using the 99th percentile of hsTnT plus a ≥20% change, 25 additional infarctions were identified. With these included, the optimal cutoff decreased to 12 ng/L at admission and 13 ng/L over time, but time to diagnosis increased. CONCLUSIONS: The gold standard used to diagnose myocardial infarction makes a major difference in the results. When myocardial infarction is diagnosed using hscTnT 99th percentile values with a 20% change, more are identified, diagnosis is delayed, and the optimal value for use is reduced.

Guided implant surgery with modification of the technique involving the raising of a semicircular miniflap: A preliminary study

Objective: An evaluation is made of pain, swelling and peri-implant attached mucosal width after implant-based rehabilitation involving guided surgery and a modification of the technique with the raising of a semicircular miniflap, in single and partial replacements.Study design: A case-control study was carried out. The study group consisted of 12 patients with the placement of 19 implants using a guided surgery and miniflap technique. The control group consisted of 12 patients with the placement of 22 implants using the conventional technique. Each patient scored postoperative swelling and pain by means of a visual analog scale (VAS). Attached vestibular mucosa width was evaluated 12 weeks after implant placement. Results: Twelve operations were carried out in each group. Immediate aesthetics were established for all implants of the study group. One implant failed in each group. Maximum pain was recorded after 6 hours in both groups (mean VAS score 4 and 4.9 in the study and control group, respectively). Maximum swelling was recorded after 24 hours (mean VAS score 2.5) in the study group and on the second day (mean VAS score 3.4) in the control group. The mean attached vestibular mucosa width was 2.9 mm in the study group and 3.2 mm in the control group. Conclusion: In this preliminary study, guided implant surgery with a semicircular miniflap in single and partial replacements resulted in slightly less postoperative pain and swelling than with the conventional implant technique. The attached vestibular mucosa width was greater in the control group, though the differences were very small (AU)

Guided implant surgery with modification of the technique involving the raising of a semicircular miniflap: a preliminary study.

OBJECTIVE: An evaluation is made of pain, swelling and peri-implant attached mucosal width after implant-based rehabilitation involving guided surgery and a modification of the technique with the raising of a semicircular miniflap, in single and partial replacements. STUDY DESIGN: A case-control study was carried out. The study group consisted of 12 patients with the placement of 19 implants using a guided surgery and miniflap technique. The control group consisted of 12 patients with the placement of 22 implants using the conventional technique. Each patient scored postoperative swelling and pain by means of a visual analog scale (VAS). Attached vestibular mucosa width was evaluated 12 weeks after implant placement. RESULTS: Twelve operations were carried out in each group. Immediate aesthetics were established for all implants of the study group. One implant failed in each group. Maximum pain was recorded after 6 hours in both groups (mean VAS score 4 and 4.9 in the study and control group, respectively). Maximum swelling was recorded after 24 hours (mean VAS score 2.5) in the study group and on the second day (mean VAS score 3.4) in the control group. The mean attached vestibular mucosa width was 2.9 mm in the study group and 3.2 mm in the control group. CONCLUSION: In this preliminary study, guided implant surgery with a semicircular miniflap in single and partial replacements resulted in slightly less postoperative pain and swelling than with the conventional implant technique. The attached vestibular mucosa width was greater in the control group, though the differences were very small.

Satisfaction of patients fitted with implant-retained overdentures

Objective: to evaluate patient satisfaction with implant-retained overdentures, and its relationship with age, sex,period of follow-up, the rehabilitated jaw (maxilla, mandible or both), number of implants, splinting, type of attachmentand the antagonist.Material and methods: the study comprised patients with overdentures fitted betweenJanuary 1996 and June 2007, and with a minimum follow-up of one year. Data regarding patients and prostheseswere collected. The patients indicated their overall satisfaction on a visual analogue scale (VAS) from 0 to 10,as well as satisfaction for individual items such as aesthetics, speech, mastication, prosthetic stability and selfesteem.These data were collected one month after fitting the prostheses, at 12 months and at a final examination.Statistical analyses were made using the SPSS version 15, statistical significance was considered for p<0.05.Results:the study included 95 patients, 43 men and 52 women, with a mean age of 55.9 years; 76 edentulous mandiblesand 31 edentulous maxillae were rehabilitated with 107 overdentures. One hundred and thirty-seven implantswere placed in the maxilla, and 224 in the mandible. The mean level of overall satisfaction was 9 at one month offitting the prosthesis, 8.8 at 12 months and 8.7 at the final control (mean 71 months).Conclusions: the patients fittedwith implant-retained overdentures expressed a high level of overall satisfaction, independently of age, sex, lengthof follow-up, rehabilitated jaw, number of implants per overdenture, whether splinted or non-splinted, and type ofattachment. Men were more satisfied with mastication and stability (AU)

Satisfaction of patients fitted with implant-retained overdentures.

OBJECTIVE: to evaluate patient satisfaction with implant-retained overdentures, and its relationship with age, sex, period of follow-up, the rehabilitated jaw (maxilla, mandible or both), number of implants, splinting, type of attachment and the antagonist. MATERIAL AND METHODS: the study comprised patients with overdentures fitted between January 1996 and June 2007, and with a minimum follow-up of one year. Data regarding patients and prostheses were collected. The patients indicated their overall satisfaction on a visual analogue scale (VAS) from 0 to 10, as well as satisfaction for individual items such as aesthetics, speech, mastication, prosthetic stability and self-esteem. These data were collected one month after fitting the prostheses, at 12 months and at a final examination. Statistical analyses were made using the SPSS version 15, statistical significance was considered for p<0.05. RESULTS: the study included 95 patients, 43 men and 52 women, with a mean age of 55.9 years; 76 edentulous mandibles and 31 edentulous maxillae were rehabilitated with 107 overdentures. One hundred and thirty-seven implants were placed in the maxilla, and 224 in the mandible. The mean level of overall satisfaction was 9 at one month of fitting the prosthesis, 8.8 at 12 months and 8.7 at the final control (mean 71 months). CONCLUSIONS: the patients fitted with implant-retained overdentures expressed a high level of overall satisfaction, independently of age, sex, length of follow-up, rehabilitated jaw, number of implants per overdenture, whether splinted or non-splinted, and type of attachment. Men were more satisfied with mastication and stability.

Palatal positioning of implants in severely resorbed edentulous maxillae.

PURPOSE: The aim of this study was to evaluate implant-supported restorations supported by palatally positioned implants as an alternative treatment for rehabilitation of the atrophic maxilla and to assess the satisfaction of patients with the results. MATERIALS AND METHODS: A retrospective case study was conducted on completely edentulous subjects who received palatally positioned implants (placed and loaded) between January 2000 and January 2004. Inclusion criteria were patients with severely resorbed edentulous maxillae (Class IV or V maxillary atrophy, according to the Cawood and Howell classification) who requested implant-supported restorations and had a follow-up period of at least 24 months after implant loading. Panoramic radiographs and maxillary computerized tomograms had been made for all patients prior to treatment. Mesial and distal implant bone loss was measured on panoramic radiographs, and the largest value was designated as the bone loss for the implant in question. Subjects indicated their degree of satisfaction with the new prosthesis after 12 months on a visual analogue scale. RESULTS: Sixty-nine patients with severely resorbed edentulous maxillae were included in the study. Four hundred and ninety implants (six to eight in each patient) were placed to support 69 fixed prostheses; 330 were in palatal positions and 160 were in molar positions (84 over the crest in the first molar position and 76 in anatomic buttresses). The success rate of palatally positioned implants was 97.8% (323/330). The mean bone loss of implants with palatal anchorage after 2 years of loading was 0.61 mm (range, 0 to 3.10 mm). All patients had stable prostheses at the end of the observation period. Patients were satisfied with comfort and stability, ability to speak, ease of cleaning, esthetics, and function of the prosthesis. CONCLUSION: Implants placed in a palatal position may be a viable alternative for rehabilitation of the atrophied maxilla.

Zygomatic bone graft for oral-antral communication closure and implant placement.

The roots of molar and premolar maxillary teeth are often very close to the floor of the maxillary sinus. As a result, extraction of these teeth can leave an oral-antral communication or lead to a fistula that requires treatment. A woman with an oral-antral communication secondary to extraction of a maxillary molar is presented. The communication was closed by means of a bone graft harvested from the wall of the sinus (zygomatic bone). After 3 months, 2 dental implants were placed, one in the pterygoid area and the other with parasinusal angulation. Rehabilitation followed in the form of a screw-retained, fixed prosthesis 3 months after implant placement. There have been no complications after 1 year of follow-up. This surgical technique allowed closure of an oral-antral communication produced by molar extraction through placement of a zygomatic bone graft and subsequent placement of 2 dental implants.

Restoration with implants in patients with recessive dystrophic epidermolysis bullosa and patient satisfaction with the implant-supported superstructure.

PURPOSE: The use of endosseous implants in the prosthetic restoration of edentulous patients with recessive dystrophic epidermolysis bullosa (RDEB) may provide improved outcomes when compared with traditional prosthetic methods. The aim of this study was to evaluate the feasibility of placing endosseous implants in patients with RDEB and to compare the treatment outcomes of fixed and removable implant-supported restorations in the edentulous maxilla or mandible with the main emphasis on patient response. MATERIALS AND METHODS: Six patients with RDEB were treated with implants. All patients were completely edentulous in either the maxilla or mandible and had marked oral involvement, with alterations in the soft and hard tissues in all cases. Three patients were treated with fixed, screw-retained implant-supported prostheses, and 3 were treated with removable implant-supported prostheses. Six months after prosthetic restoration, patients were given a questionnaire to assess their psychologic well-being and satisfaction with the implant-supported restoration marked on a visual analog scale. RESULTS: A total of 38 dental implants (21 maxillary, 17 mandibular) were placed in 6 patients. The implant success rate was 97.9%. The average follow-up from implant placement was 5.5 years (range, 1 to 9). The fixed and removable implant-supported prostheses were associated with improvements in comfort and retention, function, esthetics and appearance, taste, speech, and self-esteem. The level of satisfaction was slightly higher in patients with a fixed prosthesis. CONCLUSION: These findings suggest that endosseous implants can be successfully placed and provide support for prostheses in patients with RDEB. Patients with fixed prostheses and overdentures were satisfied with their implant-supported prostheses in the edentulous maxilla and mandible.

Complete fixed prostheses over implants in patients with oral epidermolysis bullosa.

PURPOSE: This study was conducted to evaluate the feasibility of placing fixed prostheses over endosseous implants in edentulous patients with recessive dystrophic epidermolysis bullosa. PATIENTS AND METHODS: Three cases of dental implants with fixed prostheses are presented. All 3 patients had marked oral involvement, with devastating alterations in the soft and hard tissues. The use of fixed prostheses avoids contact between the prosthesis itself and the oral mucosa, thus preventing the formation of blisters. RESULTS: A total of 27 implants (15 maxillary and 12 mandibular) were placed. One maxillary implant failed; the rest integrated successfully, allowing crown placement. The average follow-up after implant placement was 3 years (range, 1 to 5 years). CONCLUSIONS: Our findings suggest that endosseous implants are not contraindicated and can be placed successfully to improve these patients' quality of life. Implants can provide support for complete fixed prosthesis restoration in patients with epidermolysis bullosa. This procedure keeps the prosthesis from rubbing on the oral mucosa and prevents the development of ulcerations, improving mastication and esthetics.

Pain and inflammation after periapical surgery in 60 patients.

PURPOSE: Periapical surgery is followed by manifestations such as pain and swelling, the magnitude of which depends on the degree of tissue damage produced. A study is made of pain and inflammation in the 7 days after periapical surgery and its relation to patient age, gender, smoking, oral hygiene, the location and number of teeth implicated, the duration of the operation, the type of incision and flap involved, and the extent of ostectomy. MATERIALS AND METHODS: Sixty patients (22 males, 38 females) with a mean age of 38.7 years underwent periapical surgery with ultrasound and retrograde filling with silver amalgam. The postoperative course was evaluated based on a descriptive 4-point scale of pain and swelling. The SPSS statistical package for Microsoft Windows (SPSS, Chicago, IL) was used for the statistical analysis of the results. RESULTS: The greatest prevalence of maximum intensity pain was recorded after 2 days (in 14.6% of all patients); at this point two-thirds of the patients reported either no pain or only mild intensity pain. Swelling likewise peaked on the second postoperative day, when two-thirds of the patients presented moderate inflammation. Patient age, gender, oral hygiene, and smoking exerted no influence on the postoperative period (P > .05). Pain was greater when treating anterior sector mandibular teeth and when trapezoidal incisions were made. Inflammation in turn increased with longer surgical times, and pain and swelling increased with the number of teeth treated. CONCLUSIONS: Periapical surgery caused little pain and moderate swelling during the first 2 days after the intervention. The secondary manifestations increased with the number of teeth treated and with the duration of surgery.

Right-to-left interatrial shunt despite normal pulmonary artery pressure. Anatomical implications.

Platypnea-orthodeoxia is a rare syndrome characterized by dyspnea induced by the upright position and relieved by supine position and an arterial deoxygenation increased by the upright position which improves during recumbency. In many cases, this syndrome has been associated with patent foramen ovale and right-to-left shunt. Several anatomical factors that can alter the atrial anatomy and facilitate shunting through an interatrial communication have been related with this syndrome. We present a case in which an enlarged aortic root was the main anatomical factor that contributed to transient right-to-left shunting induced by postural changes.

Immediate loading in oral implants. Present situation.

The earliest antecedents of immediate loading were introduced by Ledermann in 1979. He placed overdenture in four interforaminal implants on the same day the surgery was carried out. In the original implantological protocol of Brånemark the immediate loading did not appear indicated, currently, it is being presented as a predictable alternative in several studies. We revised different articles on immediate loading from 1997 to 2002. We analysed different variables and concluded that immediate loading produces a success rate in posterior maxilla similar to the differed loading (90-100%). The characteristics of the implant, favourable to immediate loading, are: screw-shaped, with a rough surface, sand blasted and acid etching processed and a minimum length of 10 mm. The initial stability and a micro movement of the implant, inferior to 150 microm and a marginal to the insertion equal or superior to 32 N/cm are defined as a proper osseous. The bruxism stands out as an adverse factor according to several authors.

Radiologic study of marginal bone loss around 108 dental implants and its relationship to smoking, implant location, and morphology.

PURPOSE: To investigate peri-implant bone resorption around 108 ITI dental implants 1 year after prosthetic loading using extraoral panoramic, conventional intraoral periapical, and digital radiologic techniques. MATERIALS AND METHODS: A total of 108 implants were placed (59 in the maxilla and 49 in the mandible) in 42 patients (16 men and 26 women) with a mean age of 44.2 years (range 14 to 68 years). Orthopantomographic, conventional periapical, and digital radiographs were obtained at loading and again 1 year later. Bone loss was calculated from the difference between the initial and final measurements. RESULTS: Mean loss in alveolar bone height was determined to be 1.36 mm by extraoral panoramic radiography, 0.76 mm by intraoral periapical radiography, and 0.95 mm by digital radiography. The implants located in the maxilla and those placed in patients who smoked 11 to 20 cigarettes per day were associated with significantly greater bone loss. DISCUSSION: The results in relation to peri-implant bone loss in the first year after loading were similar to those published by other authors. CONCLUSION: Conventional periapical films and digital radiographs were more accurate than orthopantomography in the assessment of peri-implant bone loss. Smoking and implant location in the maxilla were associated with increased peri-implant marginal bone resorption.

Implantes inmediatos a la exodoncia. Situación actual / Immediate implants after extraction. A review of the current situation

Los implantes inmediatos son insertados en el mismo acto quirúrgico en el cual se extrae el diente a sustituir. Su porcentaje de éxito varía según diferentes autores entre un 92,7 % y 98,0 %. Su principal indicación es la sustitución de dientes con patologías sin posibilidad de tratamiento. Entre sus ventajas, respecto a los implantes diferidos, están el disminuir la reabsorción ósea del alvéolo post-extracción, el acortar el tiempo de tratamiento rehabilitador y evitar una segunda cirugía de implantación. Como inconvenientes están el requerir, generalmente, técnicas de regeneración ósea guiada con membranas, con el riesgo de exposición e infección de la misma; y la necesidad de injertos mucogingivales para el cierre del alvéolo y/o cubrir las membranas. Los requisitos quirúrgicos incluyen una exodoncia con el menor trauma posible, respetar las paredes alveolares y un curetaje alveolar minucioso que elimine todo tejido patológico. La estabilidad primaria es un requisito fundamental, se obtiene con una implantación que sobrepase en 3-5 mm el ápice alveolar o un implante de mayor diámetro que el alvéolo remanente. Una emergencia estética, en la zona anterior, se consigue insertando el implante subcrestalmente entre 1-3 mm. Respecto a la regeneración ósea guiada del alvéolo, no existe un consenso entre los diferentes autores en cuanto a la utilización de membranas y el tipo de material de relleno. El cierre primario de la herida es algo deseable aunque para algunos autores no tiene gran relevancia (AU)

Immediate implants are positioned in the course of surgical extraction of the tooth to be replaced. The percentage success of such procedures varies among authors from 92.7-98.0%. The main indication of immediate implantation is the replacement of teeth with pathologies not amenable to treatment. Its advantages with respect to delayed implantation include reduced post-extraction alveolar bone resorption, a shortening of the rehabilitation treatment time, and the avoidance of a second surgical intervention. The inconveniences in turn comprise a general requirement for membrane-guided bone regeneration techniques, with the associated risk of exposure and infection, and the need for mucogingival grafts to seal the socket space and/or cover the membranes. The surgical requirements for immediate implantation include extraction with the least trauma possible, preservation of the extraction socket walls and thorough alveolar curettage to eliminate all pathological material. Primary stability is an essential requirement, and is achieved with an implant exceeding the alveolar apex by 3-5 mm, or by placing an implant of greater diameter than the remnant alveolus. Esthetic emergence in the anterior zone is achieved by 1-3 mm sub-crest implantation. Regarding guided regeneration of the alveolar bone, the literature lacks consensus on the use of membranes and the type of filler material required. While primary wound closure is desirable, some authors do not consider it to be of great relevance (AU)

Immediate implants after extraction. A review of the current situation.

Immediate implants are positioned in the course of surgical extraction of the tooth to be replaced. The percentage success of such procedures varies among authors from 92.7-98.0%. The main indication of immediate implantation is the replacement of teeth with pathologies not amenable to treatment. Its advantages with respect to delayed implantation include reduced post-extraction alveolar bone resorption, a shortening of the rehabilitation treatment time, and the avoidance of a second surgical intervention. The inconveniences in turn comprise a general requirement for membrane-guided bone regeneration techniques, with the associated risk of exposure and infection, and the need for mucogingival grafts to seal the socket space and/or cover the membranes. The surgical requirements for immediate implantation include extraction with the least trauma possible, preservation of the extraction socket walls and thorough alveolar curettage to eliminate all pathological material. Primary stability is an essential requirement, and is achieved with an implant exceeding the alveolar apex by 3-5 mm, or by placing an implant of greater diameter than the remnant alveolus. Esthetic emergence in the anterior zone is achieved by 1-3 mm sub-crest implantation. Regarding guided regeneration of the alveolar bone, the literature lacks consensus on the use of membranes and the type of filler material required. While primary wound closure is desirable, some authors do not consider it to be of great relevance.