ABSTRACT
Natural tall colophony and its modification by monoethanolamine are moderate allergens at intracutaneous and epicutaneous ways of sensibilization reproduction. In the conditions of 30-days inhalational exposure in concentrations on the level of Limch modified by monoethanolamine colophony does not cause sensitization; while the modified tall colophony induces a weakly expressed allergic effect in experimental guinea pigs--albinos.
Subject(s)
Allergens/immunology , Drug Hypersensitivity/immunology , Hypersensitivity, Delayed/chemically induced , Leukocytes/immunology , Resins, Plant/adverse effects , Animals , Ethanolamine , Ethanolamines/pharmacology , Guinea PigsABSTRACT
Fungicide tecto (thiabendazol) is a low-toxic compound, produces a weak skin-resorptive and local irritating effect. Cumulation coefficient is 3.96. Threshold and subthreshold doses for tecto were determined as a result of 12-months chronic experiment on white rats--3.7 and 0.37 mg/kg, respectively. The allowable 24-hours dose for human exposure to the chemical is 0.6 mg. The threshold tecto concentration according to the effect on the general sanitary regimen of water reservoirs appeared to be 1 mg/l. According to the limiting toxicological index 0.05 mg/l was recommended as tecto MAC for the water of reservoirs.