ABSTRACT
CONTEXT: The correlation of serum and salivary lipid profile has been poorly characterized. The most commonly used laboratory diagnostic procedures for lipid profile involve analysis of cellular and chemical constituents of blood/plasma. As a diagnostic aid, saliva offers many advantages over serum. AIMS: To evaluate and compare the serum and salivary lipid profile levels in healthy individuals and to validate the role of saliva as a non-invasive diagnostic tool for assessing lipid profile. SETTINGS AND DESIGN: The present study was a prospective study. MATERIALS AND METHODS: A total of 100 healthy study subjects who had no complaint or any major illness in recent past were selected. The parameters assessed included serum and salivary: total cholesterol (TC), high-density lipoprotein-cholesterol (HDLC), low-density lipoprotein-cholesterol (LDLC), very low-density lipoprotein-cholesterol (VLDLC) and triglycerides (TGL). STATISTICAL ANALYSIS USED: Evaluation of results and statistical analysis was carried out using descriptive, correlation and regression analysis. RESULTS: There was a moderate level of correlation between serum and salivary TC, TGL, HDLC and VLDLC and there was a low and quite small correlation between serum and salivary LDLC. For all the five parameters assessed as a part of lipid profile, the correlation coefficients were highly significant statistically and also, with an increase in the serum mean values, corresponding increase in the saliva mean values for all the five parameters was noted. CONCLUSIONS: From the present study we conclude that saliva can be used as a non-invasive diagnostic tool for assessing lipid profile.
