Utilization and effectiveness of a weight-based heparin nomogram at a large academic medical center.

OBJECTIVE: To determine the utilization rate of a weight-based heparin nomogram and to assess the performance of the nomogram outside of experimental conditions. STUDY DESIGN: Prospective cohort analysis. PATIENTS AND METHODS: A total of 747 consecutive patients treated with intravenous heparin therapy for any indication on an internal medicine service were evaluated for the utilization rate of the weight-based nomogram, the time needed to exceed heparin's therapeutic threshold (activated partial thromboplastin time [aPTT] of > 1.5 times the control value), and the time needed to achieve heparin's therapeutic range (aPTT of 1.5 to 2.4 times the control value). Physicians were encouraged to use the weight-based nomogram by using conventional continuing medical education techniques and by configuring the computerized order entry system to give physicians an equally easy and voluntary choice between choosing the weight-based nomogram or ordering heparin in the traditional fashion. RESULTS: The study program had no effect in increasing the utilization rate of the nomogram; this rate remained the same as before the program was initiated (10%). Less time was needed both to exceed the therapeutic threshold and to achieve a therapeutic range with the weight-based nomogram compared with physician-guided dosing (P < .001 and P = .021, respectively). No difference was demonstrated between the weight-based and physician-guided groups in incidence of bleeding complications or in the proportion of patients with one or more supratherapeutic aPTTs. CONCLUSIONS: The weight-based nomogram led to superior intermediate outcomes compared with physician-guided dosing. However, despite efforts intended to modify physician behavior, the utilization rate remained so low that it was ineffective. Further research into the reasons why physicians chose not to use the weight-based nomogram and further research into methods to translate efficacious therapies into effective patient care are indicated.

Serotonin syndrome. Presentation of 2 cases and review of the literature.

Serotonin syndrome is an underreported complication of pharmacotherapy that has been relatively ignored in the medical literature. We discuss 2 recent cases seen at our institution and 39 cases described in the English-language literature since 1995. We found that patients with serotonin syndrome most often (74.3%) presented within 24 hours of medication initiation, overdose, or change in dosage. The most common presenting symptoms and signs were confusion, agitation, diaphoresis, tachycardia, myoclonus, and hyperreflexia. The prevalences of hypertension, coma/unresponsiveness, seizures, and death were not as prominent in our study as previously reported, perhaps reflecting earlier recognition and intervention. The most common therapeutic intervention was supportive care alone (48% of patients). The use of 5-hydroxytryptamine (5-HT) antagonists such as cyproheptadine, however, has become more common and might reduce the duration of symptoms. Only 1 death occurred, and most patients (57.5%) had complete resolution of their symptoms within 24 hours of presentation. The increased use of serotonergic agents (alone and in combination) across multiple medical disciplines presents the possibility that the prevalence and clinical significance of this condition will rise in the future. Internists will need to be increasingly aware of and prepared for this pharmacologic complication. Prevention, early recognition of the clinical presentation, identification and removal of the offending agents, supportive care, and specific pharmacologic therapy are all important to the successful management of serotonin syndrome.

A surplus of physicians? The view of internists at a single institution.

BACKGROUND: The sizable increase in the United States physician workforce over the last 25 years has led to a concern by health policy analysts that we are training too few generalist physicians, too many specialists and too many doctors altogether. Nearly all analysts' studies report that the United States currently has an adequate or more than adequate supply of physicians; however, few reports discuss practicing physicians' view of the issues. OBJECTIVE: To determine internists' opinion regarding the current and future physician supply and specialty mix. DESIGN: Analysis of results of a mailed questionnaire. SETTING: Nine hundred bed academic medical center in southern Connecticut. PARTICIPANTS: Three hundred seventy eight internal medicine attendings, fellows and residents. MEASURES: Seventeen questions that covered 4 domains: is there or will there be a surplus of general internists, internal medicine subspecialists or total physicians in Connecticut or the United States; which internal medicine subspecialties have a current surplus; what is the correct primary care/specialty care mix for our physician workforce; and what subspecialties are current internal medicine residents planning to pursue? RESULTS: A total of 378 of 686 (55%) mailed surveys were returned. The majority of physicians reported that there is currently no surplus of physicians (68%) or general internists (90%) in the Unites States, but that there is a surplus of internal medicine subspecialists (68%). The majority of the physicians who responded that there is no current surplus reported that there would not be a surplus in 10 years. Subspecialties most frequently indicated to have a surplus in the United States were cardiology (70%) and gastroenterology (57%). A majority of internal medicine residents (66%) indicated that they planned to pursue subspecialty fellowship; the fellowship most commonly indicated was cardiology (23%). CONCLUSIONS: In contrast to the opinion of most health policy analysts, the majority of internists associated with our institution do not believe that there is or will be a physician surplus in the United States. Reasons for a difference of opinion between practicing internists and health policy analysts are worthy of further study.

A web-based risk management and medical-legal curriculum for graduate medical education.

An educational Web site on the topic of risk management and medical-legal issues was designed. The site incorporates a 25-question multiple-choice quiz where resident responses were stored in a database for quantitative analysis. Residents who browsed the educational module scored significantly higher on the quiz (81%) than those who did not (62%). The authors conclude that the Web site and accompanying quiz database offer a practical solution for the uniform delivery of risk management in graduate medical education.

The use of a spectrophotometric assay to study the interaction of S-adenosylmethionine synthetase with methionine analogues.

We have developed a continuous spectrophotometric assay for S-adenosylmethionine synthetase and, using this assay, have examined the interaction of five potential inhibitors with the E. coli enzyme. S-Vinylhomocysteine and S-allylhomocysteine were found to be substrates, while S-(methanethio)cysteine and S-(methanethio)homocysteine were found to be competitive inhibitors. S-Cyanohomocysteine is neither a substrate nor an inhibitor.