ABSTRACT
The object of this study was to find out, by means of statistical-mathematical methods, whether the serum concentrations of Zn and Cu had a role in the interrelation among immunoglobulins IgA, IgM, IgG in four groups of subjects with various forms of liver diseases. It was found that the correlation structure between IgA, IgM, IgG and the serum concentration of Zn or Cu were different in the four types of diseases studied, and also that of these two metal ions, Zn was the most important, influencing the interdependence between the immunoglobulins in the active forms of disease.
Subject(s)
Copper/blood , Hepatitis A/blood , Hepatitis B/blood , Hepatitis C/blood , Immunoglobulin A/blood , Immunoglobulin G/blood , Immunoglobulin M/blood , Liver Cirrhosis/blood , Zinc/blood , Acute Disease , Analysis of Variance , Humans , Regression AnalysisABSTRACT
The interdependence between the serum Zn, Ca, Mg concentrations was studied in a group of healthy subjects comparatively with a group of patients with various form of cancer. It was found that it is significant difference between the control group and the groups of cancer patients, which shows that the carcinogenic processes disturb the concentrations of these metallic ions, not only quantitatively but also the interdependence between them.
Subject(s)
Calcium/blood , Magnesium/blood , Neoplasms/blood , Zinc/blood , Breast Neoplasms/blood , Female , Humans , Male , Prostatic Neoplasms/blood , Reference Values , Spectrophotometry, AtomicABSTRACT
The paper presents the estimations of the short-time and the long-time (10 years) risks of developing a cardiovascular disease (CD). The standard risk factors considered were: age, deviation from the ideal weight, number of cigarettes smoked per day, level of serum cholesterol and systolic blood pressure. The cardiovascular diseases likely to be induced by these risk factors were: myocardial infarction, angina pectoris, ischemic heart diseases and stroke. The comparison of the estimated probabilities of developing the disease for various risk factors profiles emphasizes the value of epidemiologic intervention already in young agers.
Subject(s)
Cardiovascular Diseases/epidemiology , Adult , Age Factors , Follow-Up Studies , Humans , Incidence , Male , Middle Aged , Probability , Risk Factors , Romania/epidemiology , Time FactorsABSTRACT
The level of circulating immune complexes (CIC) was studied before and after treatment in a group of 86 patients with multiple sclerosis (MS) (36 males and 50 females) ranging in age between 20 and 30 years and in 32 controls. CIC determinations were performed both in the serum and in the CSF, using the method of precipitation in polyethylene glycol (PEG). In 61.62% of the patients the mean serum CIC values (82.44 ODU; p = 0.01) exceeded those found in the controls (60.1 ODU) while the CSF mean CIC values (21.63 ODU; p = 0.05) exceeded those in the controls in 59.30% of the patients (12.8 ODU). The prevalence of patients with CIC values exceeding the control values presented variations according to the clinical stage of disease. Thus in the acute stage 83.33% of the patients presented the highest mean serum CIC values (110.5 ODU; p = 0.05) and 100% of the patients presented the highest mean CSF CIC values (27.9 ODU). After treatment it was observed that the prevalence of patients with high CIC values decreased. In conclusion it was observed that there is a correlation between the prevalence of patients with increased CIC values in the serum and CSF, and the clinical stage and treatment administered. This observation suggests that CIC determinations both in the serum and in the CSF may constitute an immunologic marker in MS.
Subject(s)
Antigen-Antibody Complex/analysis , Multiple Sclerosis/immunology , Adult , Biomarkers/chemistry , Cerebrospinal Fluid/immunology , Female , Humans , Male , Multiple Sclerosis/epidemiology , Multiple Sclerosis/therapy , Precipitin Tests , PrevalenceABSTRACT
The object of the paper is to determine by the discriminant analysis if there is a significant difference in the lipid configuration of two samples of subjects, one formed of patients recuperated after myocardial infarction and the other one of healthy subjects without ischemic heart disease, and in case there is, which of the lipid components contributes significantly to this difference.
Subject(s)
Cardiovascular Diseases/epidemiology , Lipids/blood , Cardiovascular Diseases/blood , Discriminant Analysis , Humans , Male , Middle Aged , Myocardial Infarction/blood , Myocardial Infarction/epidemiologyABSTRACT
The Romanian product Silimarina (synonym Legalon) was administered in a randomized double-blind trial, to a group of 180 patients with chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and hepatic cirrhosis (HC). The trial lasted for 40 days. The results showed favourable effects similar with those obtained with other preparations produced by foreign drug industries. The Romanian product proved to have no toxic effect. The authors discuss the present possibilities of estimating the evolution of chronic liver disease.
Subject(s)
Flavonoids/therapeutic use , Liver Diseases/drug therapy , Silymarin/therapeutic use , Chronic Disease , Clinical Trials as Topic , Double-Blind Method , Hepatitis, Chronic/blood , Hepatitis, Chronic/drug therapy , Humans , Liver Cirrhosis/blood , Liver Cirrhosis/drug therapy , Liver Diseases/blood , Random Allocation , Silymarin/adverse effectsABSTRACT
The purpose of this paper is to study the risks of developing a cardiovascular disease, under conditions of primary prevention. The risk factors were studied as a synthetic index, representing a linear weighted combination, called by us prognostic index. For the longitudinal study and prediction the multiple regression analysis was used.
Subject(s)
Cerebrovascular Disorders/etiology , Adult , Humans , Hypercholesterolemia/complications , Hypertension/complications , Longitudinal Studies , Male , Middle Aged , Obesity/complications , Prognosis , Regression Analysis , Risk , Romania , SmokingABSTRACT
The aim of this work was to determine the normal values of erythro-, leuko-, and thrombocytes in several groups of population situated in various geographic areas (hills, plain, sea-side), considering that such data could be useful for the delimitation between the normal conditions and the near-normal ones. Sixteen hematologic parameters have been investigated in 2,053 healthy subjects, insisting particularly on those most frequently required in the clinic, i.e., erythrocytes/microliter, hemoglobin (g%), hematocrit (%), leukocytes/microliter, and thrombocytes/microliter. No significant differences related to the geographic areas were recorded. The normal values of the hematologic parameters are presented in separate tables.
Subject(s)
Blood Cells/physiology , Altitude , Blood Cell Count , Erythrocyte Indices , Female , Humans , Male , Reference Values , Romania , Sex FactorsABSTRACT
Methods of multidimensional mathematical statistics were used for the combination of a set of simultaneous characteristics (risk factors) related to the development of ischemic heart disease into a single representative value as an index of the individual state. Successive values of this index give the time dependent changes of the individual state of health. Considering that these changes in time can be modelled linearly a classification criterion can be obtained taking also into account the evolution of the individual state of health.
Subject(s)
Coronary Disease/prevention & control , Coronary Disease/etiology , Humans , Models, Theoretical , Risk , Statistics as TopicABSTRACT
In the epidemiologic study of chronic diseases, especially that of cancer and heart disease, it is often necessary to resort not only to the work of epidemiologists but also to that of mathematicians and statisticians. The present study is an application of two main methods of multivariate analysis -- factorial analysis and canonical correlation analysis -- to the determination of the evolution of the risk to develop coronary heart disease in an urban population.
