ABSTRACT
Sarcoidosis is a systemic disease characterized by non-caseating granulomas that rarely involve the thyroid gland. Thyroid sarcoidosis has seldom been documented, and few cases have so far been described in association with hyperthyroidism. Here, we review the literature on this association, report two patients presenting with hyperthyroidism and histologically-proven sarcoidosis, and discuss related clinical, biochemical, pathological and genetic findings.
Subject(s)
Hyperthyroidism/complications , Sarcoidosis/complications , Sarcoidosis/diagnosis , Thyroid Diseases/complications , Thyroid Diseases/diagnosis , Adult , Female , Humans , Hyperthyroidism/diagnosis , Hyperthyroidism/pathology , Male , Middle Aged , Sarcoidosis/pathology , Thyroid Diseases/pathology , Thyroid Gland/pathologyABSTRACT
Four cases of cloacogenic carcinoma (CC) observed between 1982 and 1987 out of 175 operations performed in the same period for anorectal tumors are reported. All the patients underwent abdominoperineal resection; 3 of them are still alive at 16.30 and 42 months from surgery respectively. The fourth died for neoplastic diffusion after 12 months. Epidemiological, clinical and therapeutic features of this rare tumor are discussed.
Subject(s)
Carcinoma, Transitional Cell/surgery , Rectal Neoplasms/surgery , Adult , Aged , Carcinoma, Transitional Cell/pathology , Carcinoma, Transitional Cell/radiotherapy , Female , Humans , Lymphatic Diseases , Male , Middle Aged , Rectal Neoplasms/pathology , Rectal Neoplasms/radiotherapyABSTRACT
The authors studied a case of mucin-producing adenoma of the thyroid gland. The tumor consisted almost entirely of signet-ring cells containing mucin, which was strongly positive with PAS, with and without diastase pre-treatment, and Alcian blue stain at pH 2.5. Immunoperoxidase staining for thyreoglobulin was clearly positive within the cytoplasm of signet-ring cells and also in the follicle material, which indicates that the tumor derived from follicular epithelium.
