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Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia.

Cuadros, Marta; Andrades, Álvaro; Coira, Isabel F; Baliñas, Carlos; Rodríguez, María I; Álvarez-Pérez, Juan Carlos; Peinado, Paola; Arenas, Alberto M; García, Daniel J; Jiménez, Pilar; Camós, Mireia; Jiménez-Velasco, Antonio; Medina, Pedro P.

Blood Cancer J ; 9(12): 93, 2019 11 25.

Article in English | MEDLINE | ID: mdl-31767830

Subject(s)

Gene Expression Regulation, Neoplastic , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/mortality , RNA Interference , RNA, Long Noncoding/genetics , Biomarkers, Tumor , Core Binding Factor Alpha 2 Subunit/genetics , Female , Gene Expression Profiling , Humans , Male , Oncogene Proteins, Fusion/genetics , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy , Prognosis

SWI/SNF proteins as targets in cancer therapy.

Schiaffino-Ortega, Santiago; Balinas, Carlos; Cuadros, Marta; Medina, Pedro P.

J Hematol Oncol ; 7: 81, 2014 Nov 13.

Article in English | MEDLINE | ID: mdl-25391308

ABSTRACT

Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

Subject(s)

Chromosomal Proteins, Non-Histone/metabolism , Neoplasms/metabolism , Neoplasms/therapy , Transcription Factors/metabolism , Chromosomal Proteins, Non-Histone/genetics , Humans , Molecular Targeted Therapy , Neoplasms/genetics , Transcription Factors/genetics

Subject(s)

ABSTRACT

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