[Effect of nootropes on quantitative changes in the rat cerebral cortex GABA(A) receptor complexes under experimental hypokinesia conditions].

The influence of picamilon and piracetam on the quantitative changes in the central GABA(A) macromolecular receptor complexes in the rat brain has been investigated under the experimental conditions of hypokinesia. It was found that the injection of these nootropes under the conditions of 7-day hypokinesia and 4-day recovery period did not show visible changes in the amount of active GABA(A) receptors. However, the injection of picamilon under the conditions of 15-day hypokinesia and 8-day recovery period showed a tendency to restoration of the number of active GABA(A) receptors.

[The effect of hypokinesia on depression and on the central GABA-A receptor complexes in the rat brain].

The influence of a 15-day hypokinesia on the development of anxiety-depression state and quantitative changes in the central GABA-A macromolecular receptor complexes in the rat brain has been investigated under conditions of the despair (forced swim) test. Simultaneously, the effects of well-known nootropic drugs picamilon and piracetam on the dynamics of state parameters in the experimental animals have been evaluated. It was found that hypokinesia led to the development of anxiety and depression accompanied by reduction in the amount of active GABA-A receptors. The injections of piracetam and picamilon showed a tendency to restoration of the number of active GABA-A receptors and to normalization of the behavioral parameters.

[Cerebral blood flow and thrombocyte aggregation at different times of hypokinesia and their regulation by antiaggregants]. / Mozgovoi krovotok, agreguemost' trombotsitov v razlichnye sroki gipokinezii i ikh reguliatsiia antiagregantami.

Changes in local cerebral blood flow and in microcirculatory channels in the cortex of rat brain were studied in conditions of early and remote hypokinesia. The rheological parameters of blood were studied in patients which stayed in ber for a long time in traumatological hospitals. We showed that by the 60th day of hypokinesia and in conditions of active readaptation the disordered cerebral blood flow starts to stabilize and tendency to normalization of some parameters of the cerebral blood flow and microcirculatory channels become clearly seen. The study of the functional state of the platelets showed that prescription of antiaggregants along with physical training can prevent thromboembolic aggravations associated with hypokinesia.

[The characteristics of the action of GABA-ergic agents on the brain microcirculation during motor activity and hypodynamia]. / Ob osobennostiakh deistviia GAMK-ergicheskikh sredstv na mikrotsirkuliatsiiu mozga v usloviiakh dvigatel'noi aktivnosti i gipodinamii.

Changes in the microcirculatory bed of the rat brain cortex during motor activity and hypodynamia under the action of piracetam, GABA and bicuculline were studied. The possibility of the development of compensatory processes due to the cerebral blood flow increase under the influence of GABA agonists at a disturbance of the cerebral hemodynamics in combination with increased locomotor activity and also due to the improvement of the microcirculation at early stages of hypodynamia induced by administration of GABA agonists opens up new perspectives in the use of GABA-positive drugs.

[Effects of GABA and piracetam on the development of experimental cerebral infarction in rats and platelet aggregation in patients with cerebrovascular disorders]. / Vliianie GAMK i piratsetama na razvitie éksperimental'nogo infarkta mozga u krys i agregatsiiu trombotsitov u bol'nykh s sosudistoi patologiei golovnogo mozga.

GABA and Piracetam caused the improvement of the morphological state of cerebral infarction, due to intracarotid infusion of Arachidonic acid. The effect of GABA was more pronounced. The diminishing of antiaggregatory effect of Piracetam arose in patients with acute cerebrovascular disturbances, compared with the donor group. In contrast, the antiaggregatory activity of GABA increased in the patients group. The improvement of cerebral circulation under influence of GABA can be ascribed to its rheological changes.

[Mechanism of action of piracetam on cerebral circulation]. / O nekotorykh mekhanizmakh deistviia piratsetama na mozgovoe krovoobrashchenie.

The experimental data show that piracetam exerts a marked effect on cerebral hemodynamics producing a lowering of cerebral artery tonus and an increase of local blood flow. In addition, an increase of GABA content is noted, particularly following an experimentally-induced disorder of cerebral blood circulation. A stable dilatation of the mean capillary diameter, a decrease of the number of non-functioning capillaries in the brain cortex after piracetam administration indicate an important role of piracetam as a cyclic analogue of GABA in regulation and compensation of disordered cerebral hemodynamics.

[Motor activity and the content of neuroactive amino acids in brain tissues]. / Dvigatel'naia aktivnost' i soderzhanie neiroaktivnykh aminokislot v tkaniakh mozga.

The influence of forced motor activity (swimming) on quantitative shifts in neuroactive amino acids (GABA, glutamic and aspartic acids and glycine) was studied in brain tissues of rats and cerebrospinal fluid of cats in health and brain circulation disturbances. The data obtained point to the elevation of the content of amino acids in the brain and appearance of GABA in the cerebrospinal fluid during brain ischemia.