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1.
J Biomed Mater Res A ; 101(3): 613-21, 2013 Mar.
Article in English | MEDLINE | ID: mdl-22926966

ABSTRACT

Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T(1) measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity.


Subject(s)
Contrast Media/chemistry , Dendrimers/chemistry , Gadolinium DTPA/chemistry , Polypropylenes/chemistry , Cell Line , Contrast Media/pharmacology , Dendrimers/pharmacology , Drug Evaluation, Preclinical , Fibroblasts/cytology , Fibroblasts/metabolism , Gadolinium DTPA/pharmacology , Humans , Polypropylenes/pharmacology
2.
Org Lett ; 12(1): 8-11, 2010 Jan 01.
Article in English | MEDLINE | ID: mdl-19954167

ABSTRACT

A general method to synthesize various alphabeta alphabeta bis-strapped porphyrins, with a different functionalization on each side of the macrocycle, is described. The resulting new chelates may find applications as analogues of heme protein active sites, bifunctional chelates, or specific bis-chelating molecules with potential medical utility.


Subject(s)
Chelating Agents/chemical synthesis , Metalloporphyrins/chemical synthesis , Binding Sites , Chelating Agents/chemistry , Hemeproteins/drug effects , Metalloporphyrins/chemistry , Models, Molecular , Molecular Structure , Stereoisomerism
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