1.
Arch Pharm Res
; 23(4): 332-7, 2000 Aug.
Article
in English
| MEDLINE
| ID: mdl-10976579
ABSTRACT
This study describes the synthesis, in vitro evaluation and molecular modeling study of novel compounds for the inhibition of TNF-alpha production. Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone (9) was selected as a lead compound and its pyridine derivative 10 was more potent in activity and safer than rolipram.
