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J Ethnopharmacol ; 107(3): 431-41, 2006 Oct 11.
Article in English | MEDLINE | ID: mdl-16698206

ABSTRACT

Several plants are used in folk medicine to treat gastrointestinal disorders. Mouriri pusa Gardn. (Melastomataceae) is a medicinal plant commonly used in the central region of Brazil against gastric ulcer. Two organic extracts methanolic (MeOH) and dichloromethane (DCM) obtained by sequential extraction from the leaves of Mouriri pusa were evaluated for their ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3M HCl/60% EtOH, absolute ethanol, non-steroidal anti-inflammatory drug, stress and pylorus ligature) in mice and rats. The best results were obtained after pretreatment with MeOH extract whereas the DCM extract did not show the same significant antiulcerogenic activity. No acute toxicity was observed in animals treated with 5 g/kg, p.o. of MeOH extract. The mechanism involving the antiulcerogenic action of MeOH extract seemed to be related to NO generation and also suggested the effective participation of endogenous sulfhydryl group in the gastroprotective action. Phytochemical investigation of the MeOH extract of Mouriri pusa yielded tannins, flavonoids and (-)-epicatechin. The presence of these phenolic compounds probably would explain the antiulcerogenic effect of the polar extract of Mouriri pusa leaves.


Subject(s)
Anti-Ulcer Agents/pharmacology , Gastric Mucosa/drug effects , Melastomataceae , Nitric Oxide/metabolism , Stomach Ulcer/prevention & control , Sulfhydryl Compounds/metabolism , Animals , Anti-Inflammatory Agents, Non-Steroidal , Anti-Ulcer Agents/chemistry , Anti-Ulcer Agents/therapeutic use , Anti-Ulcer Agents/toxicity , Brazil , Enzyme Inhibitors/pharmacology , Ethanol , Ethylmaleimide/pharmacology , Gastric Acid/metabolism , Gastric Acidity Determination , Gastric Mucosa/metabolism , Gastrointestinal Motility/drug effects , Hydrochloric Acid , Male , Medicine, Traditional , Mice , NG-Nitroarginine Methyl Ester/pharmacology , Nitric Oxide Synthase/antagonists & inhibitors , Plant Extracts/pharmacology , Plant Leaves , Pylorus/surgery , Rats , Rats, Wistar , Stomach Ulcer/chemically induced , Stomach Ulcer/etiology , Stomach Ulcer/metabolism , Stress, Physiological/complications , Sulfhydryl Reagents/pharmacology
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