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Am J Perinatol ; 18(7): 379-85, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11731891

ABSTRACT

The objective of this study is to test a four-dose Hepatitis B vaccine schedule in premature infants (PI) and assess the immunogenicity of the vaccine with this schedule. We studied 29 PI who received the vaccine against Hepatitis B at birth, 1, 5, and 9 months of age. Antibodies against surface antigen (Anti-HBs) were measured before the third and fourth doses and 12 weeks after the fourth dose. Levels higher than 10 mIU/mL were considered protective, whereas more than 100 mIU/mL was an excellent response. Twenty-nine PI were studied. The average weight at the time of the initial dose was 1398 g, gestational age of 32.5 weeks, and a postnatal age of 9 days. Since the initial measurement, protective levels were achieved in all patients. The response was excellent in 24.1, 75.9, and 89.7%, after the second, third, and fourth doses, respectively. No correlation was found between the type of response and the infants' weight or the postnatal age. The Anti-HBs geometrical levels were 51.9, 133, and 133 mIU/mL after the second, third, and fourth doses, respectively. The favorable results obtained might be due to: the four-dose schedule itself, the dose we used (10 microg), the time interval between the doses, and even a race factor. Our schedule seems to be useful for PI infants and probably is no longer necessary to delay the vaccination, although this should be confirmed by further studies.


Subject(s)
Hepatitis B Vaccines/administration & dosage , Hepatitis B Vaccines/immunology , Immunization Schedule , Infant, Premature/immunology , Vaccination/methods , Dose-Response Relationship, Immunologic , Drug Administration Schedule , Hepatitis B Antibodies/blood , Humans , Infant, Newborn , Longitudinal Studies , Mexico , Treatment Outcome
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