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1.
Nutr Hosp ; 39(6): 1306-1315, 2022 Dec 20.
Article in Spanish | MEDLINE | ID: mdl-36354003

ABSTRACT

Introduction: Introduction: patients undergoing major abdominal surgery, including colorectal surgery, particularly if they are oncological patients, are at risk of malnutrition with a worse postoperative evolution and an increase in complications. Objectives: to assess the prevalence of malnutrition in patients undergoing colon and rectal surgery in our hospital, and to identify the different risk factors for malnutrition. Methods: a retrospective cohort study including all patients operated on for colorectal cancer in our environment. Results: a total of 382 patients with a mean age of 69.93 years were included in the study. Considering different risk factors for malnutrition, we obtained that 50.6 % of the patients had some of the risk indicators for malnutrition altered at the time of admission. The variables that proved to be independent factors related to malnutrition were age, DM, baseline malnutrition, and heart disease. Preoperative malnutrition turned out to be the greatest risk factor for presenting moderate/severe malnutrition in the postoperative period with an OR of 3.83 (2.1-6.9; p < 0.001), and was also associated with a higher incidence of postoperative complications and longer hospital stays. We obtained that the percentage of postoperative complications was significantly higher in the group of patients diagnosed with peroperative malnutrition (36.3 % vs 22.0 %, p = 0.004). Conclusions: the percentage of malnutrition in patients with colorectal cancer is high, an aspect that is underestimated in most surgical services. In our study, malnutrition leads to worse outcomes with an increase in complications.


Introducción: Introducción: los pacientes sometidos a cirugía mayor abdominal, y más si se trata de pacientes oncológicos, son pacientes en riesgo de desnutrición, lo que conlleva una peor evolución posoperatoria y un aumento de las complicaciones. Objetivos: conocer la prevalencia de la desnutrición en los pacientes sometidos a cirugía de colon y recto en nuestro medio hospitalario e identificar los distintos factores de riesgo de desnutrición. Métodos: estudio de cohortes retrospectivo incluyendo a todos los pacientes intervenidos de cáncer colorrectal de forma programada en nuestro medio hospitalario. Resultados: se incluyeron en el estudio 382 pacientes con una edad media de 69,93 años. Considerando distintos factores de riesgo de desnutrición, obtuvimos que un 50,6 % de los pacientes tenían alterado alguno de los indicadores de riesgo de desnutrición en el momento del ingreso. Las variables que mostraron ser factores independientes relacionados con la desnutrición fueron la edad, la DM, la desnutrición basal y la cardiopatía. La desnutrición preoperatoria resultó ser el factor de mayor riesgo para presentar desnutrición moderada/grave en el posoperatorio con un OR de 3,83 (2,1-6,9; p < 0,001) y además se asoció a una mayor incidencia de complicaciones posoperatorias y a estancias hospitalarias más prolongadas. Obtuvimos que el porcentaje de complicaciones posoperatorias fue significativamente mayor en el grupo de pacientes diagnosticados de desnutrición peroperatoria (36,3 % vs. 22,0 %, p = 0,004). Conclusiones: el porcentaje de desnutrición en los pacientes con cáncer colorrectal es elevado, aspecto subestimado en la mayoría de los servicios quirúrgicos. La desnutrición conlleva en nuestro estudio una peor evolución con un incremento de las complicaciones.


Subject(s)
Colorectal Neoplasms , Malnutrition , Humans , Aged , Retrospective Studies , Prognosis , Colorectal Neoplasms/surgery , Risk Factors , Postoperative Complications/epidemiology
2.
Nutr. hosp ; 39(6): 1306-1315, nov.-dic. 2022. graf, tab
Article in Spanish | IBECS | ID: ibc-214838

ABSTRACT

Introducción: los pacientes sometidos a cirugía mayor abdominal, y más si se trata de pacientes oncológicos, son pacientes en riesgo de desnutrición, lo que conlleva una peor evolución posoperatoria y un aumento de las complicaciones. Objetivos: conocer la prevalencia de la desnutrición en los pacientes sometidos a cirugía de colon y recto en nuestro medio hospitalario e identificar los distintos factores de riesgo de desnutrición. Métodos: estudio de cohortes retrospectivo incluyendo a todos los pacientes intervenidos de cáncer colorrectal de forma programada en nuestro medio hospitalario. Resultados: se incluyeron en el estudio 382 pacientes con una edad media de 69.93 años. Considerando distintos factores de riesgo de desnutrición, obtuvimos que un 50.6 % de los pacientes tenían alterado alguno de los indicadores de riesgo de desnutrición en el momento del ingreso. Las variables que mostraron ser factores independientes relacionados con la desnutrición fueron la edad, la DM, la desnutrición basal y la cardiopatía. La desnutrición preoperatoria resultó ser el factor de mayor riesgo para presentar desnutrición moderada/grave en el posoperatorio con un OR de 3.83 (2.1-6.9; p < 0.001) y además se asoció a una mayor incidencia de complicaciones posoperatorias y a estancias hospitalarias más prolongadas. Obtuvimos que el porcentaje de complicaciones posoperatorias fue significativamente mayor en el grupo de pacientes diagnosticados de desnutrición peroperatoria (36.3 % vs. 22.0 %, p = 0.004). Conclusiones: el porcentaje de desnutrición en los pacientes con cáncer colorrectal es elevado, aspecto subestimado en la mayoría de los servicios quirúrgicos. La desnutrición conlleva en nuestro estudio una peor evolución con un incremento de las complicaciones. (AU)


Introduction: patients undergoing major abdominal surgery, including colorectal surgery, particularly if they are oncological patients, are at risk of Malnutrition with a worse postoperative evolution and an increase in complications. Objectives: to assess the prevalence of Malnutrition in patients undergoing colon and rectal surgery in our hospital, and to identify the different risk factors for Malnutrition. Methods: a retrospective cohort study including all patients operated on for colorectal cancer in our environment. Results: a total of 382 patients with a mean age of 69,93 years were included in the study. Considering different risk factors for Malnutrition, we obtained that 50,6 % of the patients had some of the risk indicators for Malnutrition altered at the time of admission. The variables that proved to be independent factors related to Malnutrition were age, DM, baseline Malnutrition, and heart disease. Preoperative Malnutrition turned out to be the greatest risk factor for presenting moderate/severe Malnutrition in the postoperative period with an OR of 3,83 (2,1-6,9; p < 0,001), and was also associated with a higher incidence of postoperative complications and longer hospital stays. We obtained that the percentage of postoperative complications was significantly higher in the group of patients diagnosed with peroperative Malnutrition (36,3 % vs 22,0 %, p = 0,004). Conclusions: the percentage of Malnutrition in patients with colorectal cancer is high, an aspect that is underestimated in most surgical services. In our study, Malnutrition leads to worse outcomes with an increase in complications. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Colorectal Neoplasms/surgery , Malnutrition , Retrospective Studies , Postoperative Complications , Aging , Risk Factors
6.
Cir Cir ; 82(2): 231-9, 2014.
Article in Spanish | MEDLINE | ID: mdl-25312325

ABSTRACT

BACKGROUND: Procalcitonin is a quite specific biomarker of infection and in recent years has shown its superiority to others markers of inflammation, such as C-reactive protein, for the diagnosis and monitoring of a variety of infections. AIM: For this reason, several researchers have studied the potential role of procalcitonin for diagnosis and management of these infections. DISCUSSION: Intra-abdominal infections are a heterogeneous group of infections that, sometimes, pose difficult challenges to physicians. The published studies have produced mixed results, leading to controversy on the utility of this marker in intra-abdominal infections. CONCLUSIONS: This review summarizes these data and discuss the utility of procalcitonin in several intra abdominal infections, including postoperative infections.


Antecedentes: la procalcitonina es un marcador bastante específico de infección y en los últimos años se ha demostrado su superioridad, con respecto a otros marcadores de inflamación como la proteína C reactiva, para el diagnóstico y vigilancia de una gran variedad de infecciones. Objetivo: resumir los datos actualmente existentes y discutir la utilidad de la procalcitonina en diversas infecciones intrabdominales, incluidas las postoperatorias. Conclusiones: los resultados de estudios hasta ahora publicados son variables, lo que genera controversia en relación con su utilidad.


Subject(s)
Calcitonin/blood , Inflammation/blood , Intraabdominal Infections/blood , Protein Precursors/blood , Acute Disease , Anti-Bacterial Agents/therapeutic use , Appendicitis/blood , Appendicitis/diagnosis , Appendicitis/drug therapy , Biomarkers , C-Reactive Protein/analysis , Calcitonin/physiology , Calcitonin Gene-Related Peptide , Humans , Inflammation/diagnosis , Intestinal Obstruction/blood , Intestinal Obstruction/diagnosis , Intraabdominal Infections/diagnosis , Intraabdominal Infections/drug therapy , Pancreatitis/blood , Pancreatitis/diagnosis , Pancreatitis/drug therapy , Peritonitis/blood , Peritonitis/diagnosis , Peritonitis/drug therapy , Postoperative Complications/blood , Postoperative Complications/diagnosis , Postoperative Complications/drug therapy , Prognosis , Protein Precursors/physiology
7.
Cir. Esp. (Ed. impr.) ; 92(4): 240-246, abr. 2014. ilus, tab
Article in Spanish | IBECS | ID: ibc-120691

ABSTRACT

OBJETIVO: Evaluar la asociación entre niveles séricos de procalcitonina (PCT) y proteína C reactiva (PCR), en los 3 primeros días de postoperatorio, y la aparición de infección intraabdominal postoperatoria. MÉTODO: Estudio observacional prospectivo que incluye a 67 pacientes intervenidos quirúrgicamente de cáncer colorrectal, gástrico y pancreático. Los niveles séricos de PCT y PCR se midieron antes de la cirugía y a las 24, 48 y 72 h de la misma. Se registraron los valores de PCT y PCR, así como su fiabilidad para la detección de infección intraabdominal postoperatoria. RESULTADOS: La incidencia de infección intraabdominal postoperatoria fue de 13,4%. Los valores de PCR a las 72 h, los valores de PCT a las 24, 48 y 72 h y el cociente entre el valor de PCR a las 72 h y el valor de PCR a las 48 h (PCR D3/PCR D2) se asociaron significativamente con la aparición de infección intraabdominal postoperatoria. La sensibilidad más alta correspondió al valor de PCT a las 72 h (88,9%); la especificidad más alta y el valor predictivo positivo (VPP) más alto, al cociente PCR D3/PCR D2 (96,49 y 71,4%, respectivamente); el valor predictivo negativo (VPN) más alto, al valor de PCT a las 72 h y a las 24 h (97,7 y 96%, respectivamente). CONCLUSIÓN: Los valores de PCT se asocian significativamente con la aparición de infección intraabdominal postoperatoria en los 3 primeros días de postoperatorio. Su sensibilidad y VPP son bajos, pero su VPN es alto, incluso a las 24 h de la cirugía


AIM: to evaluate the association between serum levels of procalcitonin and C-reactive protein, on the first 3 postoperative days, and the appearance of postoperative intra-abdominal infection. METHOD: Prospective observational study including 67 patients operated on for colo-rectal, gastric and pancreatic cancer. Serum levels of procalcitonin and C-reactive protein were analyzed before surgery and daily until the third postoperative day. Values of procalcitonin (PCT) and C-reactive protein (CRP) were recorded as well as their accuracy for detection of postoperative intra-abdominal infection (PIAI). RESULTS: The incidence of postoperative intra-abdominal infection was 13.4%. CRP serum levels at 72 h, PCT serum levels at 24, 48 and 72 h and the ratio between serum levels of CRP at 72 hours and serum levels of CRP at 48 hours (CRP D3/CRP D2) were significantly associated with the appearance of postoperative intra-abdominal infection. The highest sensitivity corresponded to PCT at 72 hours (88.9%); the highest specificity and positive predictive value corresponded to the ratio CRP D3/CRP D2 (96.49% and 71.4%, respectively); the highest negative predictive value to procalcitonin at 72 h and 24 h. CONCLUSIONS: Serum levels of PCT are significantly associated with the appearance of postoperative intra-abdominal infection. Sensitivity and predictive positive values are low, but negative predictive value is high, even at 24 h after surgery


Subject(s)
Humans , Surgical Wound Infection/diagnosis , C-Reactive Protein/analysis , Abdomen/surgery , Calcitonin Gene-Related Peptide/analysis , Biomarkers/analysis , Postoperative Complications/diagnosis
8.
Cir Esp ; 92(4): 240-6, 2014 Apr.
Article in Spanish | MEDLINE | ID: mdl-24445075

ABSTRACT

AIM: to evaluate the association between serum levels of procalcitonin and C-reactive protein, on the first 3 postoperative days, and the appearance of postoperative intra-abdominal infection. METHOD: Prospective observational study including 67 patients operated on for colo-rectal, gastric and pancreatic cancer. Serum levels of procalcitonin and C-reactive protein were analyzed before surgery and daily until the third postoperative day. Values of procalcitonin (PCT) and C-reactive protein (CRP) were recorded as well as their accuracy for detection of postoperative intra-abdominal infection (PIAI). RESULTS: The incidence of postoperative intra-abdominal infection was 13.4%. CRP serum levels at 72h, PCT serum levels at 24, 48 and 72h and the ratio between serum levels of CRP at 72hours and serum levels of CRP at 48hours (CRP D3/CRP D2) were significantly associated with the appearance of postoperative intra-abdominal infection. The highest sensitivity corresponded to PCT at 72hours (88.9%); the highest specificity and positive predictive value corresponded to the ratio CRP D3/CRP D2 (96.49% and 71.4%, respectively); the highest negative predictive value to procalcitonin at 72h and 24h. CONCLUSIONS: Serum levels of PCT are significantly associated with the appearance of postoperative intra-abdominal infection. Sensitivity and predictive positive values are low, but negative predictive value is high, even at 24h after surgery.


Subject(s)
C-Reactive Protein/analysis , Calcitonin/blood , Gastrointestinal Neoplasms/surgery , Intraabdominal Infections/blood , Postoperative Complications/blood , Protein Precursors/blood , Adult , Aged , Aged, 80 and over , Biomarkers/blood , Calcitonin Gene-Related Peptide , Female , Humans , Male , Middle Aged , Prospective Studies
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