ABSTRACT
OBJECTIVE: To propose a method of diagnosis of mild papilloedema (PO) using peripapillary total retinal (PTR) thickness measurement by spectral domain optical coherence tomography (OCT). METHODS: 24 eyes in 24 patients with PO caused by increased intracranial pressure and 22 eyes in 22 normal subjects were studied. OCT high-quality fundus images were analysed and graded by three masked observers using the Modified Frisén Scale. Eyes with PO were divided into two subgroups: those with mild PO (n=18) and those with moderate-severe PO (n=6). Two methods of measurements were evaluated and compared: retinal nerve fibre layer (RNFL) thickness measurements using standard optic disc cube 200 × 200 acquisition protocol and PTR thickness measurements using the 'macular' cube 512 × 128 acquisition protocol centred on the optic disc. Thickness values were calculated globally and for each quadrant (temporal, superior, nasal, inferior) and compared among the three groups (control, mild PO, moderate-severe PO). The main outcome measures were RNFL and PTR thickness. RESULTS: Average RNFL and PTR thickness in the moderate-severe PO, mild PO and control groups were 299.3 ± 10.9, 112.4 ± 6.3, 96 ± 5.7 and 804.5 ± 17, 463.1 ± 9.8 and 332.4 ± 8.9 µm, respectively. Moderate-severe PO differed from mild PO and control groups using both RNLF thicknesses and PTR thicknesses measurements. Mild PO did not differ from controls using RNLF thickness measurement (p=0.17), but was statistically different using PTR thickness measurement (p<0.001). CONCLUSION: PTR thickness measurement increases the sensitivity of detection of mild PO compared with conventional RNFL measurement. This new way of using OCT may be useful for clinicians to detect mild PO.
Subject(s)
Diagnostic Techniques, Ophthalmological , Optic Disk/pathology , Papilledema/diagnosis , Tomography, Optical Coherence/methods , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Nerve Fibers/pathology , Retina/pathology , Retinal Ganglion Cells/pathologyABSTRACT
AIM: To report the efficacy of external local radiotherapy in the treatment of choroidal metastases. PATIENTS AND METHODS: The study reports four cases of patients with choroidal metastases of lung neoplasm confirmed by the bronchial biopsy. Polychemotherapy was associated with external radiotherapy of the ocular metastases. DISCUSSION AND CONCLUSION: The external radiotherapy dose of 30 Gy to the posterior segment of the eye in 10 fractions was effective and seemed to be the most appropriate management of choroidal metastasis despite the use of the newest molecules in chemotherapy.
Subject(s)
Adenocarcinoma/drug therapy , Adenocarcinoma/radiotherapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Choroid Neoplasms/drug therapy , Choroid Neoplasms/radiotherapy , Lung Neoplasms/drug therapy , Lung Neoplasms/radiotherapy , Adenocarcinoma/pathology , Adenocarcinoma of Lung , Aged , Choroid Neoplasms/secondary , Drug Therapy, Combination , Female , Humans , Lung Neoplasms/pathology , Male , Middle Aged , RadiotherapyABSTRACT
It is rarer for a patient to present with transient binocular visual loss than transient monocular visual loss. This symptom usually results from a cerebral dysfunction. When transient binocular visual loss results from papilledema, ophthalmological examination is critical for an accurate diagnosis. In other cases, examination may be normal and a thorough history is of paramount importance for making a diagnosis and deciding whether or not imaging is necessary. The three main cerebral causes for transient binocular visual loss are migraine with visual aura, partial seizures occurring in the occipital lobe, and vertebrobasilar ischemia.
