Subject(s)
Physicians/history , Austria , History, 20th Century , Humans , Hungary , Journalism, Medical , Pathology/history , Pediatrics/history , Switzerland , Training Support/history , United StatesABSTRACT
Eosinophilia is associated with several diseases of the upper respiratory tract. The predominance of eosinophils in nasal tissue, secretions, and lavage fluid has been used as an aid in the diagnosis of allergic rhinitis. Charcot-Leyden crystals, considered to be a morphologic hallmark of eosinophil-related disease, are often also found in inflamed nasal tissue and paranasal sinus contents of patients with allergic rhinitis. These bipyramidal-shaped crystals are composed of the enzyme lysolecithin acylhydrolase, one of several eosinophilic proteins that damage respiratory epithelium and contribute to the pathology of allergy in the upper respiratory tract.
Subject(s)
Eosinophilia/pathology , Glycoproteins/analysis , Rhinitis/pathology , Eosinophilia/etiology , Humans , Lysophospholipase , Rhinitis/etiologyABSTRACT
Ligneous (pseudomembranous) inflammation of the female genital tract is a rare and unusual condition characterized by extensive subepithelial fibrin deposition and associated inflammation. Ligneous inflammation in extragenital sites, predominantly the conjunctiva, has been linked to plasminogen deficiency. Individuals with plasminogen deficiency are unable to remove fibrin deposited in injured mucosal tissue. Severe systemic ligneous inflammation involving the female genital tract that is linked to hypoplasminogenemia has not previously been described. We present a patient with ligneous inflammation of her genital, middle ear, and oral mucosa that was associated with type-1 homozygous plasminogen deficiency due to a novel missense mutation in the plasminogen gene.
Subject(s)
Genital Diseases, Female/pathology , Plasminogen/deficiency , DNA/chemistry , DNA/genetics , Ear Diseases/etiology , Ear Diseases/pathology , Female , Genital Diseases, Female/etiology , Gingival Diseases/etiology , Gingival Diseases/pathology , Humans , Inflammation/etiology , Inflammation/pathology , Middle Aged , Mutation, Missense , Plasminogen/genetics , Polymerase Chain Reaction , Polymorphism, Single-Stranded ConformationalSubject(s)
Anthrax/diagnosis , Bacillus anthracis/isolation & purification , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/microbiology , Adult , Edema/microbiology , Edema/pathology , Fatal Outcome , Gastric Mucosa/microbiology , Gastric Mucosa/pathology , Gastrointestinal Hemorrhage/microbiology , Gastrointestinal Hemorrhage/pathology , Humans , Male , Stomach Ulcer/microbiology , Stomach Ulcer/pathologyABSTRACT
BACKGROUND: Most physicians are unaware of the juxtaoral organ (of Chievitz) and its clinical significance. The aim of this review is to draw attention to the clinical importance of this organ. METHODS: Review and interpretation of the English and non-English literature pertaining to the juxtaoral organ. RESULTS: The juxtaoral organ is a small structure located within the soft tissue overlying the angle of the mandible in the buccotemporal space. It is composed of an epithelial parenchyma embedded in a highly organized connective tissue stroma rich in nerves and sensory receptors innervated by the buccal nerve. This metabolically active structure presumably serves as a mechanosensor in the lateral wall of the oral cavity. Needless surgical removal of this juxtaoral structure is therefore best avoided. In children, the normal organ may be discovered as a small mass in the cheeks, which may lead to extensive and unnecessary investigations. Hyperplasia of the parenchyma may occur, but carcinoma originating from this organ has not been reported. CONCLUSION: Awareness of this normal anatomic structure is important, because the finding of epithelial islands intimately admixed with nerves could be misinterpreted as perineural invasion by carcinoma.
Subject(s)
Cheek , Connective Tissue/blood supply , Connective Tissue/innervation , Mechanoreceptors/physiology , Mouth Mucosa/blood supply , Mouth Mucosa/innervation , Animals , Diagnosis, Differential , Humans , Mechanoreceptors/cytology , Mouth DiseasesABSTRACT
The most frequent form of idiopathic calcinosis is tumoral calcinosis (TC) which rarely occurs at young ages. We describe here a TC case of a young boy with its light microscopy completed with electron microscopic examinations. X-ray microanalysis revealed in the intracellular crystals CaCl2 besides the previously described hydroxyapatite. The significance of this finding is unknown at the moment.
