ABSTRACT
Antenatal and postpartum depression has been associated with maternal, child and family-unit complications. Our aim was to assess the impact of a depression screening and intervention program on perinatal complications. This study included 2042 women. They were screened on the Edinburgh Postnatal Depression Scale (EPDS), three times during pregnancy and once after childbirth. If their EPDS score was above the cut-off score, psychological intervention was offered. Significant relationships were found between depression scores and perinatal complications, such as protracted cervical dilation, protracted descent, preeclampsia, intrauterine growth restriction, low birthweight and cesarean section. Depression scores were higher in the intervention group, compared to the non-intervention group, but decreased after the consultations. The cesarean section rate was significantly lower in the consultation group. A rapid screening process can provide an adequate tool to identify women who are more likely to have such complications due to depression.
Subject(s)
Depressive Disorder/therapy , Pregnancy Complications/psychology , Pregnancy Complications/therapy , Psychiatric Status Rating Scales/statistics & numerical data , Psychosocial Intervention/methods , Psychotherapy/methods , Adolescent , Adult , Cesarean Section/psychology , Cesarean Section/statistics & numerical data , Depression, Postpartum/diagnosis , Depression, Postpartum/psychology , Depression, Postpartum/therapy , Depressive Disorder/diagnosis , Depressive Disorder/psychology , Female , Humans , Hungary , Pregnancy , Pregnancy Complications/diagnosis , Referral and Consultation , Young AdultABSTRACT
Slow wave oscillation is a synchronous oscillatory mechanism that is a characteristic wave type of the cerebral cortex during physiological deep sleep or anesthesia. It may play an important role in cortical analysis of sensory input. Our goal was (1) to develop optimal conditions for the induction of this slow rhythmic activity in adult rat cortical slices, (2) to identify connections through which the activity propagates between coupled cortical regions, and (3) to study the pattern of horizontal and vertical flow of activity developed spontaneously in cortical slices. Experiments were performed on intact or differently incised rat cortical slices. According to our results, spontaneous cortical activity develops reliably in slightly modified artificial cerebrospinal fluid, first in the entorhinal cortical region of horizontally cut slices and then it spreads directly to the perirhinal (PRh) cortex. The activity readily generated in layer 2/3 of the entorhinal cortex then quickly spreads vertically to upper layer 2-3 in the same area and to the neighboring regions, that is, to the PRh cortex. Synchronization of activity in neighboring cortical areas occurs through both callosal connections and layer 2-3 intrinsic network, which are important in the propagation of spontaneous, inherent cortical slow wave activity.
Subject(s)
Brain Waves , Brain/physiology , Action Potentials , Animals , Cortical Synchronization , Male , Microelectrodes , Periodicity , Rats, Wistar , Tissue Culture Techniques/methodsABSTRACT
KEY POINTS: Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs of infra-slow oscillation. ABSTRACT: Every form of neural activity depends on temperature, yet its relationship to brain rhythms is poorly understood. In this work we examined how sleep spindles are influenced by changing brain temperatures and how brain temperature is influenced by sleep oscillations. We employed a novel thermoelectrode designed for measuring temperature while recording neural activity. We found that spindle frequency is positively correlated and duration negatively correlated with brain temperature. Local heating of the thalamus replicated the temperature dependence of spindle parameters in the heated area only, suggesting biophysical rather than global modulatory mechanisms, a finding also supported by a thalamic network model. Finally, we show that switches between oscillatory states also influence brain temperature on a shorter and smaller scale. Epochs of paradoxical sleep as well as the infra-slow oscillation were associated with brain temperature fluctuations below 0.2°C. Our results highlight that brain temperature is massively intertwined with sleep oscillations on various time scales.
