[MALT Lymphoma of the Conjunctiva in a 13-year old Child--5-Year Relapse-free Follow-up Following Antibiotic Treatment]. / MALT-Lymphom der Bindehaut bei einem 13-jährigen Kind--fünf Jahre Rezidivfreiheit nach ausschließlich antibiotischer Behandlung.

MEDICAL HISTORY: In February 2007, a 13-year old boy presented with a livid tumour in the lower conjunctival fornix of the left eye. OPHTHALMOLOGICAL FINDINGS: The tumor was salmon-coloured, bulging and elastic and filled the whole lower conjunctival fornix of the left eye. There was no other pathological finding in the left eye. Uncorrected visual acuity was 20/20. Intraocular pressure was 12 mmHg. The eye was fully motile. TREATMENT: Incisional biopsy was performed in February 2007. The tumor was histologically an extranodal MALT lymphoma. DNA testing for Chlamydophila trachomatis and Chlamydophila pneumonia was negative. Systemic treatment was started with doxycycline (200 mg daily). After six weeks, the tumour was slightly smaller. Azithromycin 500 mg once a week was added. 18 months after initiation of the treatment, the tumour had completely regressed. A second sample taking in the former tumor area showed tumor-free conjunctiva and subconjunctival tissue. As a precaution, the combined antibiotic therapy was continued for 10 months and the patient was followed for five more years. The lymphoma did not relapse in the conjunctiva and orbit or in the whole body. CONCLUSION: We showed that extranodal MALT lymphomas of the conjunctiva can be successfully treated with antibiotics alone. At the start of therapy, the child was 13 years old. To our knowledge, this patient is the first child in Germany and one of the first in the world with ocular adnexal lymphoma who could be successfully treated with combined antibiotic therapy and who could be followed up for 5 years without relapse. Thus, we could avoid radiotherapy or chemotherapy in childhood and eliminate the risk of a therapy-induced secondary malignancy.

[40 years breast carcinoma treatment in the Neubrandenburg region.Can an increase in prognostically more favorable stages be detected?]. / 40 Jahre Mammakarzinombehandlung in der Region Neubrandenburg. Lässt sich eine Verschiebung zu prognostisch günstigeren Stadien nachweisen?

The data of clinical presentation for women suffering from breast carcinoma were analysed for a period of 4 decades retrospectively. The authors have found a significant decrease in the duration of the history and an increase of early stages of the breast carcinoma. This increase was caused by the introduction of mammography. The mammography is the most important method for the diagnosis of breast carcinoma in asymptomatic women.