Subject(s)
Genital Diseases, Female/diagnosis , Tuberculin Test , Tuberculosis, Female Genital/diagnosis , Body Temperature/drug effects , Female , Genital Diseases, Female/metabolism , Humans , Injections, Subcutaneous , Lipid Peroxidation/drug effects , Malondialdehyde/blood , Tuberculin/administration & dosage , Tuberculosis, Female Genital/metabolismABSTRACT
The level of MDA in erythrocytes and plasma was determined in 71 female patients with a chronic inflammatory process in the genitals before and after subcutaneous tuberculin administration. In patients with active genital tuberculosis the MDA level rose significantly: in erythrocytes 24 hours and in plasma 72 hours after subcutaneous tuberculin administration. The MDA level remained unchanged in the rest of the patients.
Subject(s)
Erythrocytes/metabolism , Lipid Peroxidation/physiology , Malondialdehyde/blood , Tuberculin/administration & dosage , Tuberculosis, Female Genital/metabolism , Adult , Chronic Disease , Erythrocytes/drug effects , Female , Humans , Injections, Subcutaneous , Lipid Peroxidation/drug effects , Stimulation, Chemical , Time Factors , Tuberculin Test , Tuberculosis, Female Genital/bloodABSTRACT
In 80 patients with pulmonary tuberculosis aggravated by stage I-IIB cardiopulmonary insufficiency, the multimodality therapy included vektarion improving the ventilation/perfusion correlations (29 patients) and the combination of metabolic correctors (glutamevit and riboxin) (51 patients). The population analysis of peripheral blood erythrocytes (by the method of acidic erythrograms), the fractional composition of hemoglobin, the concentration of 2,3-diphosphoglycerine acid and the isozymic spectrum of LDH in erythrocytes served as methods of the treatment efficacy control. The treatment with vektarion noticeably reduced hypoxemia which was accompanied by positive shifts in erythrocyte metabolism and in the hemoglobin spectrum, producing but a negligible action on the population composition of erythrocytes. The combination of the metabolic correctors exerted a lesser effect on the fractional composition of hemoglobins, producing a well-defined positive action on erythrocyte function, decelerating the processes of their ageing. It is concluded that the highest positive effect may be produced by the combined use of all the three drugs bearing in mind their action mode.
Subject(s)
Erythrocytes/drug effects , Pulmonary Heart Disease/drug therapy , Tuberculosis, Pulmonary/drug therapy , 2,3-Diphosphoglycerate , Adult , Aged , Carbon Dioxide/blood , Chronic Disease , Diphosphoglyceric Acids/blood , Drug Therapy, Combination , Erythrocytes/metabolism , Female , Humans , Male , Middle Aged , Oxygen/blood , Partial Pressure , Pulmonary Heart Disease/blood , Pulmonary Heart Disease/etiology , Tuberculosis, Pulmonary/blood , Tuberculosis, Pulmonary/complicationsABSTRACT
Suppuration of the hemithorax cavity and bronchial fistulas complicate considerably the postoperative period in patients who underwent removal of the lung for tuberculosis. Study of the dynamics of changes of the glycosaminoglycan content, activity of hyaluronidase, trypsin-like proteinases, and elastolytic activity in the postoperative exudate allows the development of purulent complications in the cavity of the postoperative hemithorax to be detected earlier and corrected in time.
Subject(s)
Bronchi/surgery , Exudates and Transudates/metabolism , Pneumonectomy , Tuberculosis, Pulmonary/surgery , Adult , Biochemical Phenomena , Biochemistry , Endopeptidases/analysis , Exudates and Transudates/enzymology , Female , Glycosaminoglycans/analysis , Humans , Hyaluronoglucosaminidase/analysis , Male , Middle Aged , Postoperative Complications , Postoperative PeriodABSTRACT
The status of the blood kinin system, activity of serum inhibitors of proteinases (alpha 1-protease inhibitor and alpha 2-macroglobulin) as well as indices of activity of trypsin-like proteinases, elastolytic and fibrinolytic activity, free antitryptic activity and complete content of acid stable inhibitors were studied in the morning sputum and bronchoalveolar washesoff of 62 patients with intrathoracic sarcoidosis. It was shown that in active sarcoidosis proteinase-inhibitors balance got disturbed as a result of a decrease in the activity of serum inhibitors, suppression of local secretion of acid stable inhibitors and inactivation at the level of alpha 1-protease inhibitor alveoles. Excessive activation of the kinin system was noted in the blood flow and elevation of all types of proteolytic activity in the respiratory system. It was assumed that the above changes reflected disturbed self-control processes in the body and caused progression of disease and pneumofibrosis formation.
