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1.

Mapping inherited and somatic variation in regulatory DNA: new roadmap for common disease clinical discoveries.

Roukos, Dimitrios H; Baltogiannis, Giannis G; Baltogiannis, George.

Expert Rev Mol Diagn ; 13(6): 519-22, 2013 Jul.

Article in English | MEDLINE | ID: mdl-23895121

Subject(s)

DNA/genetics , Genetic Diseases, Inborn/diagnosis , Genetic Diseases, Inborn/genetics , Regulatory Sequences, Nucleic Acid , Chromosome Mapping , Genetic Diseases, Inborn/etiology , Genome, Human , Humans , Mutation

2.

Gene expression 'signature' limitations and genome architecture-based perspectives for robust cancer biomarkers.

Katsios, Christos S; Papaloukas, Costas; Roukos, Dimitrios H; Baltogiannis, George.

Biomark Med ; 7(1): 79-82, 2013 Feb.

Article in English | MEDLINE | ID: mdl-23387487

Subject(s)

Biomarkers, Tumor/metabolism , Genome, Human , Neoplasms/genetics , Gene Regulatory Networks , Humans , Neoplasms/metabolism , Neoplasms/pathology , Signal Transduction , Transcriptome

3.

Targeted therapy for colorectal cancer resistance to EGF receptor antibodies and new trends.

Katsios, Christos; Ziogas, Denosthenes E; Roukos, Dimitrios H; Baltogiannis, George.

Expert Rev Gastroenterol Hepatol ; 7(1): 5-8, 2013 Jan.

Article in English | MEDLINE | ID: mdl-23265143

Subject(s)

Antibodies/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Colorectal Neoplasms/drug therapy , Drug Resistance, Neoplasm , ErbB Receptors/antagonists & inhibitors , Protein Kinase Inhibitors/therapeutic use , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/enzymology , Colorectal Neoplasms/genetics , Colorectal Neoplasms/immunology , ErbB Receptors/immunology , Humans , Molecular Targeted Therapy , Treatment Outcome

4.

Assessing tumor heterogeneity and emergence mutations using next-generation sequencing for overcoming cancer drugs resistance.

Roukos, Dimitrios; Batsis, Charalambos; Baltogiannis, George.

Expert Rev Anticancer Ther ; 12(10): 1245-8, 2012 Oct.

Article in English | MEDLINE | ID: mdl-23176613

Subject(s)

Antineoplastic Agents/pharmacology , Mutation , Neoplasms/drug therapy , Neoplasms/genetics , Drug Resistance, Neoplasm , Humans , Sequence Analysis, DNA/methods

5.

Novel Wnt signaling and other pathway inhibitors in the colorectal cancer genomic landscape era.

Roukos, Dimitrios H; Ziogas, Demosthenes E; Papaloukas, Costas; Baltogiannis, George.

Future Oncol ; 8(11): 1373-6, 2012 Nov.

Article in English | MEDLINE | ID: mdl-23148609

Subject(s)

Antineoplastic Agents/therapeutic use , Colorectal Neoplasms/drug therapy , Colorectal Neoplasms/genetics , Genomics , Signal Transduction/drug effects , Wnt Proteins/antagonists & inhibitors , Wnt Signaling Pathway/drug effects , Colorectal Neoplasms/metabolism , Humans , Molecular Targeted Therapy

6.

Genome-based diagnostics and predictive tools: a new epoch for breast cancer management.

Ziogas, Demosthenes E; Baltogiannis, George; Spiliotis, John; Tzaphlidou, Margaret; Roukos, Dimitrios H.

Future Oncol ; 8(10): 1211-4, 2012 Oct.

Article in English | MEDLINE | ID: mdl-23130921

Subject(s)

Breast Neoplasms , Genome, Human , Breast Neoplasms/diagnosis , Breast Neoplasms/genetics , Female , Humans , Prognosis , Sequence Analysis, DNA

7.

Progress, challenges and new genome-based concepts in the multidisciplinary treatment of gastric cancer.

Katsios, Christos; Baltogiannis, George; Roukos, Dimitrios H.

Expert Rev Anticancer Ther ; 11(4): 503-6, 2011 Apr.

Article in English | MEDLINE | ID: mdl-21504316

Subject(s)

Stomach Neoplasms/genetics , Stomach Neoplasms/therapy , Clinical Trials as Topic , Combined Modality Therapy/methods , Epigenesis, Genetic , Genome , Humans , Meta-Analysis as Topic , MicroRNAs/therapeutic use , Molecular Targeted Therapy/methods

8.

Laparoscopic surgery for gastric cancer: comparative-effectiveness research and future trends.

Katsios, Christos G; Baltogiannis, George; Roukos, Dimitrios H.

Expert Rev Anticancer Ther ; 10(4): 473-6, 2010 Apr.

Article in English | MEDLINE | ID: mdl-20397910

Subject(s)

Laparoscopy/methods , Stomach Neoplasms/surgery , Cost-Benefit Analysis , Gastrectomy/economics , Gastrectomy/methods , Gastrectomy/trends , Humans , Laparoscopy/economics , Laparoscopy/trends , Quality of Life , Stomach Neoplasms/economics , Time Factors , Treatment Outcome

9.

Laparoscopic and robotic rectal cancer resection: expectations for improving oncological outcomes.

Balli, Christina; Ziogas, Dimisthenis; Roukos, Dimitrios H; Baltogiannis, George.

Ann Surg ; 251(1): 185-6; author reply 186, 2010 Jan.

Article in English | MEDLINE | ID: mdl-19940756

Subject(s)

Laparoscopy , Rectal Neoplasms/surgery , Robotics , Humans , Minimally Invasive Surgical Procedures , Neoplasm Recurrence, Local/prevention & control

10.

Continuing debate on D2 lymphadenectomy for gastric cancer.

Ziogas, Dimosthenis; Baltogiannis, George; Fatouros, Michael.

World J Surg ; 32(9): 2127-8, 2008 Sep.

Article in English | MEDLINE | ID: mdl-18563483

Subject(s)

Adenocarcinoma/pathology , Adenocarcinoma/surgery , Lymph Node Excision , Stomach Neoplasms/pathology , Stomach Neoplasms/surgery , Adult , Aged , Female , Humans , Male , Middle Aged , Neoplasm Staging , Prognosis , Survival Analysis

11.

Early gastric carcinoma with oncocytic features and extensive metastases.

Batistatou, Anna; Doukas, Michael; Baltogiannis, George; Panelos, John; Kamina, Sevasti; Charalabopoulos, Konstantinos; Agnantis, Niki J.

Pathol Res Pract ; 203(7): 539-41, 2007.

Article in English | MEDLINE | ID: mdl-17590281

ABSTRACT

We present the case of a 63-year-old Caucasian woman with early gastric adenocarcinoma, suffering from extensive metastases at the time of initial presentation. Microscopic examination of the gastrectomy specimen revealed an invasive adenocarcinoma with oncocytic features. Interestingly, despite the fact that the carcinoma was pT1, it also was found to be N2, stage IV. The biologic behavior of oncocytic adenocarcinoma of the stomach is still unclear. We would like to present this case, so that its clinicopathological characteristics can be added to the few cases already published.

Subject(s)

Adenocarcinoma/secondary , Stomach Neoplasms/pathology , Adenocarcinoma/metabolism , Female , Humans , Liver Neoplasms/secondary , Middle Aged , Neoplasm Staging , Stomach Neoplasms/metabolism

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