ABSTRACT
INTRODUCTION: Alcohol is a leading cause of liver disease and presents with high morbidity and mortality. The spectrum of disease includes Fatty liver, Alcoholic hepatitis and Alcoholic cirrhosis. Also Hepatorenal syndrome is a clinical syndrome that represents the end stage of sequence of reductions in renal perfusion, induced by severe hepatic injury. Since it is a common disease entity, a better knowledge of the clinical and laboratory features of ALD, along with knowledge of hepatorenal syndrome, its diagnosing and management criteria and its prevalence among alcoholics, helps in better management and favourable outcome of patients. MATERIALS: This study has been carried out in Wanless Hospital, Miraj, on 100 patients of liver cirrhosis including outdoor and indoor patients for a period of 2 years. Laboratory investigations, ultrasound and ascitic fluid examination was done. RESULT: Renal dysfunction was evident in 46 patients and >68% of the study population had a GFR of <60. Most common type of renal dysfunction seen was acute kidney injury, followed by hepatorenal syndrome and chronic kidney disease. CONCLUSION: In our study, prevalence of renal dysfunction in cirrhosis of liver was 46% with Acute Kidney Injury was the most common Type of Renal Dysfunction followed by Hepato-renal Syndrome and Chronic kidney disease. Renal dysfunction was observed in significantly higher percentage of patients with severe disease Child Pugh class (C) followed by Child-Pugh class (B) and Child-Pugh class (A). Sub-acute bacterial peritonitis (SBP) was the most common risk factor associated with Renal Dysfunction followed by Hyponatremia, GI bleed and Other - Infection (pneumonia). The association of Sub-acute bacterial peritonitis (SBP) with Renal Dysfunction was statistically significant. References Rehm J, Samokhvalov AV, Shield KD. Global burden of alchoholic liver diseases. J Hepatol 2013;59(1):160-168. Kamper-Jorgensen M, Gronbaek M, Tolstrup J, et al. Alcohol and cirrhosis: dose-response or threshold effect? J Hepatol 2004;41(1):25-30.
