ABSTRACT
A chemiresistive sensor is described for the lung cancer biomarker hexanal. A composite consisting of molecularly imprinted polymer nanoparticles and multiwalled carbon nanotubes was used in the sensor that is typically operated at a voltage of 4 V and is capable of selectively sensing gaseous hexanal at room temperature. It works in the 10 to 200 ppm concentration range and has a 10 ppm detection limit (at S/N = 3). The sensor signal recovers to a value close to its starting value without the need for heating even after exposure to relatively high levels of hexanal. Graphical abstract Schematic presentation of a chemiresistive sensor for detection of hexanal, a cancer biomarker. The hexanal-imprinted polymeric nanoparticles were synthesized, mixed with multiwalled carbon nanotubes and coated on the surface of an interdigitated electrode to produce a nanocomposite chemiresistor gas sensor for hexanal.
Subject(s)
Aldehydes/analysis , Lung Neoplasms/diagnosis , Molecular Imprinting , Nanotubes, Carbon/chemistry , Polymethyl Methacrylate/chemistry , Volatile Organic Compounds/analysis , Biomarkers, Tumor/analysis , Biosensing Techniques , Electrochemical Techniques , Electrodes , Gases/chemistry , Humans , Limit of Detection , Methacrylates/chemistry , Nanocomposites/chemistry , Nanoparticles/chemistry , Particle Size , Polymerization , Surface Properties , TemperatureABSTRACT
Database URL: http://bioinf.modares.ac.ir/software/cod/.
