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1.
Shock ; 59(1): 20-27, 2023 01 01.
Article in English | MEDLINE | ID: mdl-36703274

ABSTRACT

ABSTRACT: Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) can easily lead to supranormal oxygenation. The impact of hyperoxygenation beyond the early VA-ECMO support phase is unexplored. We sought to investigate its association with short- and long-term mortality. Methods: A total of 10,615 arterial blood gases of 179 patients undergoing VA-ECMO between 2013 and 2018 in our cardiosurgical tertiary center were analyzed for partial pressure of oxygen (PaO2) and its association with in-hospital, 90-day, and 1-year mortality. Patients were stratified into terciles (T) based on PaO2. Results: The median systemic PaO2 during VA-ECMO was 122 mm Hg (Q1-Q3, 111-158 mm Hg) and was significantly higher in 90-day nonsurvivors versus survivors (134 mm Hg [Q1-Q3, 114-175 mm Hg] vs. 114 mm Hg [Q1-Q3, 109-136 mm Hg]; P < 0.001). The incidence of mortality increased at all time points tested after VA-ECMO implantation along with the increasing terciles of PaO2. The lowest mortality rates were noted for patients with median PaO2 values of <115 mm Hg (T1), whereas patients with median PaO2 values of >144 mm Hg (T3) had the highest mortality rates. Bonferroni multiple testing analysis found the T3 of PaO2 to be a predictor of decreased 90-day survival in comparison with T1 (P < 0.001) and T2 (P = 0.002). Multivariable Cox regression analyses for in-hospital, 90-day, and 1-year mortality showed a significant association of the T3 compared with the T2 and the T1 of PaO2 to mortality across all endpoints. Conclusion: Hyperoxygenation during VA-ECMO might be associated with increased all-cause mortality. The results of our study further document the known toxicity of hyperoxygenation in general critical care patients and mark the need to focus specifically on VA-ECMO patients.


Subject(s)
Extracorporeal Membrane Oxygenation , Hyperoxia , Humans , Extracorporeal Membrane Oxygenation/adverse effects , Extracorporeal Membrane Oxygenation/methods , Oxygen , Hospital Mortality , Incidence , Retrospective Studies , Shock, Cardiogenic
2.
J Invasive Cardiol ; 27(6): E82-9, 2015 Jun.
Article in English | MEDLINE | ID: mdl-26028663

ABSTRACT

OBJECTIVE: The aim of this study was to determine early and long-term results after transcatheter pulmonary valve implantation (TPVI) performed with the use of Medtronic Melody and Edwards Sapien valves in patients with full conduit or patched right ventricular outflow tract (RVOT) dysfunction. METHODS AND RESULTS: The study comprised 40 consecutive patients (full conduit, n = 25; RVOT patch, n = 15) who underwent TPVI between December 2008 and April 2012. TPVI was successfully performed in 37 patients (92.5%). The gradient across RVOT decreased from 82.96 ± 37.90 mm Hg to 34.33 ± 22.2 mm Hg on the day following TPVI (P<.001) and remained low at follow-up of 20.4 ± 11.4 months. The competency of the pulmonary valve was restored and maintained during the follow-up. New York Heart Association class, right ventricle end-diastolic volume, and right ventricular ejection fraction all improved as soon as 1 month after the procedure. Infective endocarditis was observed in 4 patients (1 died). Four patients underwent surgeries due to endocarditis, homograft rupture, stent migration, and early valve compression. CONCLUSION: TPVI may be performed safely and effectively in patients with right ventricle-pulmonary artery conduit and in selected patients with patched RVOT.


Subject(s)
Heart Valve Prosthesis Implantation/methods , Heart Valve Prosthesis , Pulmonary Valve Insufficiency/surgery , Pulmonary Valve Stenosis/surgery , Adolescent , Adult , Cardiac Catheterization , Echocardiography, Doppler , Endocarditis/etiology , Endocarditis/surgery , Female , Follow-Up Studies , Heart Valve Prosthesis Implantation/adverse effects , Humans , Male , Middle Aged , Pulmonary Valve Insufficiency/diagnostic imaging , Pulmonary Valve Stenosis/diagnostic imaging , Stents/adverse effects , Stroke Volume , Treatment Outcome , Ventricular Function, Right , Young Adult
3.
Catheter Cardiovasc Interv ; 83(3): 474-81, 2014 Feb 15.
Article in English | MEDLINE | ID: mdl-23804542

ABSTRACT

BACKGROUND: Current indications for percutaneous pulmonary valve implantation (PPVI) are limited to patients who had their outflow tracts repaired with the use of a "full" condui-homograft. Patients after a patch repair are believed to have an unfavorable anatomy for PPVI. OBJECTIVES: To evaluate a novel use of Edwards SAPIEN(TM) valve for percutaneous treatment of moderate and severe pulmonary regurgitation after tetralogy of Fallot (TF) repair with a right ventricular outflow (RVOT) patch. METHODS: PPVI was intended in 10 patients (age 21-39 years, 2 ♂) with regurgitant fraction of 30-59%, measured by cardiac magnetic resonance imaging (CMRI) 16-30 years after repair with a RVOT patch. Balloon test-inflations were used for definitive measurements and location of the landing site for the valve. All RVOTs were prestented. RESULTS: Successful valve implantation was achieved in nine patients. In one patient a bare-metal stent used for prestenting embolized into pulmonary artery. A 26-mm valve was implanted in seven and a 23-mm in two patients. CMRI at 1-2 month follow-up (n = 8) demonstrated both, sustained relief of pulmonary incompetence (regurgitant fraction = 0-14%) and significant decrease of the right ventricular end-diastolic volume indexes (from 169.9 ± 43.8 to 140.0 ± 40.3 ml/m(2) , P < 0.001). At that follow-up no adverse event occurred. No stent fractures were observed. CONCLUSIONS: We report the first case series of patients with significant PR after a RVOT patch repair, successfully treated with a percutaneous Edwards SAPIEN(TM) valve implantation. The procedure is technically feasible and may be offered to patients with the outflow tracts larger than those limited by the Melody(®) system available currently.


Subject(s)
Cardiac Catheterization/instrumentation , Cardiac Surgical Procedures/adverse effects , Heart Valve Prosthesis Implantation/instrumentation , Heart Valve Prosthesis , Heart Ventricles/surgery , Pulmonary Valve Insufficiency/therapy , Tetralogy of Fallot/surgery , Adult , Cardiac Catheterization/adverse effects , Coronary Angiography , Feasibility Studies , Female , Heart Valve Prosthesis Implantation/adverse effects , Heart Valve Prosthesis Implantation/methods , Heart Ventricles/abnormalities , Heart Ventricles/physiopathology , Humans , Magnetic Resonance Imaging , Male , Patient Selection , Predictive Value of Tests , Prosthesis Design , Pulmonary Valve Insufficiency/diagnosis , Pulmonary Valve Insufficiency/etiology , Pulmonary Valve Insufficiency/physiopathology , Risk Factors , Severity of Illness Index , Time Factors , Treatment Outcome , Young Adult
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