[Some pharmacodynamic properties of the "Marysiennka" healing water from the Cieplice-Zdrój springs]. / Niektóre wlasciwosci farmakodynamiczne wody "Marysienka" ze zródla w Cieplicach-Zdroju.

On the ground of the performed experimental investigations it has been shown that the "Marysienka" water, given to rats intragastrically in a single daily dose of 14.3 cm3/kg body weight for the spans of 20 and 40 days and in the some spans of time as drinking water ad libitum, causes a statistically significant decrease of the levels of total cholesterol, total lipids, triglycerides, and an increase of the HDL fraction of cholesterol. Within the range of the investigated parameters of electrolytic economy a statistically significant fall of the level of calcium and decrease tendencies of sodium, magnesium and increase tendencies of potassium in the blood serum of the examined animals could be observed. After 20 days of the administration of the investigated water both intragastrically in a single daily dose of 14.3 cm3/kg body weight and in the animals that were receiving that water as drinking water ad libitum a marked compensated metabolic acidosis was observed. A long-lasting exposition of the rats (40 days) to that water may lead to the rise of compensated metabolic alkalosis. No essential influence of the studied water on the indicators of protein and carbohydrate metabolism and on the morphological composition of the peripheral blood and its smear was noted. The studied water shows no cholagogic effect in guinea-pigs, nor any diuretic effect in rats.

[The influence of natural peat and isolated humic acid solution on certain indices of metabolism and of acid-base equilibrium in experimental animals]. / Wplyw borowiny naturalnej i roztworu izolowanych kwasów huminowych na niektóre wskazniki przemiany materii i równowagi kwasowo-zasadowej u zwierzat doswiadczalnych.

The biological effect in rats treated with natural peat homogenate and isolated humic acids has been shown in pharmacodynamic studies. After 24 days of this treatment decrease of total cholesterol, total lipids, an increase of HDL fraction of cholesterol, decrease in glucose level and increase of protein fraction of globulin, hemoglobin, hematocrit and total number of erythrocytes were observed. The treatment did not influence the electrolyte equilibrium. However, after the treatment with humic cides the respiratory acidosis not compensated with the metabolic component was observed. The activity of the natural peat was more favorable as compared to the activity of humic acids solution.

Synthesis and biological properties of pyrazo-[3,4-B]-pyridine derivatives. II.

By aminoalkylation with diethylaminoethyl chloride of 3-hydroxypyrazo-[3,4-b]-pyridine 1 and its phenyl derivative 2 as well as 3-aminopyrazo-[3,4-b]-pyridine 7 and its phenyl derivative 8, basic ethers 5, 6 and aminoalkanoloamines 9 and 10 have been obtained. Compounds 5, 6 and 10 increased coronary blood flow of the isolated cat heart. At the concentration of 5 +/- 2 mg/ml shoved spasmolytic activity.

The influence of a new antiarrhythmic drug, Craviten (M-71) on coronary flow.

Craviten (M-71) increases the coronary flow, depresses the rate of contractions, and transiently depresses the contractile force of the cat heart in vitro and in situ. As the action of the drug is short-lasting, its usefulness in treatment of acute cardiac insufficiency accompanied by pain is suggested. It is also potentially useful in cardiac insufficiencies accompanied by arrhythmia.

Antiarrhythmic properties of Craviten (M-71) in cats and rabbits.

Preparation M-71 (Craviten, Polfa) possesses strong antiarrhythmic properties. It prevents development of cardiac arrhythmia evoked by BaCl2, ouabain and adrenaline in cats and rabbits, and abolishes the already developed arrhythmias. It prevents the aconitine-evoked arrhythmia only in rabbits.

The influence of a new antiarrhythmic drug, Craviten (M-71) on the circulatory system in cats.

Craviten, a newly synthesized ester of optically active 2-aminobutanol-1, produced in cats hypotension and inhibited excitability of sinus node and atrio-ventricular and intraventricular conduction. It acts as a spasmolytic on the isolated rabbit ileum, being approx. 100 times as potent as papaverine. Studies with drugs affecting the vegetative system indicate that the hypotensive and spasmolytic action of Craviten consists in a direct depressing action on smooth musculature.

Synthesis and biological activity of pyrazo-[3,4-b]-pyridine derivatives. Part I.

3 (3'-Morpholino-2'-hydroxypropoxy)--7--9 as well as 3 (3'-morpholino-2'-hydroxypropyloamino) 14 -- 16 derivatives of 1-methyl and 1-phenyl pyrazo-[3,4-b]-pyridines were prepared and screened for expected circulatory activity. Compounds 7, 11--14, 20 mg/kg, produced hypotension in cats; Compounds 7 and 14, 50--80 mg/kg, had antiarrhytmic action in BaCl2 -- induced arrhytmic in the rabbit.

The influence of some antidepressant drugs on cardiac function. IV. Influence of blood supply of the heart in situ.

In in situ experiments with cats, impiramine, nortriptyline and amitriptyline depressed arterial blood pressure, diminished coroncary flow and amplitude of the heart's contraction, and slowed cardiac action.

Influence of some antidepressant drugs on the circulatory system. I. Imipramine.

Imipramine exerts various, dose-related, effects on arterial blood pressure. A distinct hypotensive effect occurs at dosses of at least 0-5 mg/kg body weight. At lower dosage, the action of the drug is biphasic. In experiments in situ with animals, imipramine diminished amplitude of the heart's contractions. Controlled respiration during experiments with imipramine reduced its toxicity. In decapitated animals the action of imipramine was the same as in animals with intact central nervous system. At all dosage levels its effect on blood pressure was biphasic. Blockade of the sympathetic, parasympathetic system and vegetative ganglia had no significant effect on the circulatory response to imipramine. Low doses of imipramine potentiated the hypertensive effect of noradrenaline, and high doses weakened it.

Influence of some antidepressant drugs on the circulatory system: II. Action of amitriptyline and nortriptyline on basic circulatory parameters.

Amitriptyline and nortriptyline in doses higher than 0.5 mg/kg exert a hypotensive action, and doses of less than 0-5 mg/kg have no characteristic effect on blood pressure. Both drugs diminished amplitude of cardiac contractions in situ in experimental animals. Low doses increased frequency and amplitude of respirations, and higher doses paralyzed respiratory function. Animals died as a result of paralysis of the respiratory center. In decapitated animals both drugs exhibited activity similar to that in animals with intact central nervous system, but their hypotensive effect was less pronounced. Blockade of the sympathetic and parasympathetic systems and of vegetative ganglia had no influence on the action of amitriptyline and nortriptyline on blood pressure. In low doses both amitriptyline and nortriptyline potentiated, and in high doses weakened the hypertensive effect of noradrenaline.