Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Photosensitivity Disorders/chemically induced , Prodrugs/adverse effects , Thiazines/adverse effects , Aged , Aged, 80 and over , Anti-Infective Agents, Local/adverse effects , Arthritis/drug therapy , Benzoates/adverse effects , Female , Humans , Patch Tests , Sulfhydryl Compounds , Thimerosal/adverse effectsABSTRACT
The participation of vasoactive intestinal polypeptide (VIP) or calcitonin gene-related peptide (CGRP) in the nitrergic innervation of the canine laryngeal glands was investigated using a double-staining technique of NADPH-diaphorase (NADPHd) histochemistry and VIP or CGRP immunohistochemistry. NADPHd-positive nerve fibers with varicosities appeared to terminate in some acinar cells. Double staining revealed that NADPHd reactivity and VIP- or CGRP-like immunoreactivity were colocalized in some nerve fibers distributed around the acini. A cluster of NADPHd-positive cells were occasionally found in the larynx. Many NADPHd-positive cells had VIP-like immunoreactivity and no NADPHd-positive cells were CGRP-like immunoreactive. These findings suggest that nitric oxide participates in the neural control of the laryngeal exocrine secretion in cooperation with intrinsic VIP and/or extrinsic CGRP.
Subject(s)
Calcitonin Gene-Related Peptide/physiology , Laryngeal Nerves/physiology , Nitric Oxide/physiology , Vasoactive Intestinal Peptide/physiology , Animals , Dogs , Staining and LabelingSubject(s)
Ciprofloxacin/adverse effects , Drug Eruptions/etiology , Ofloxacin/adverse effects , Adult , Humans , MaleSubject(s)
Consciousness Disorders/etiology , Meningeal Neoplasms/complications , Multiple Myeloma/complications , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Brain/diagnostic imaging , Brain/pathology , Dexamethasone , Doxorubicin/administration & dosage , Female , Humans , Meningeal Neoplasms/drug therapy , Meningeal Neoplasms/pathology , Middle Aged , Multiple Myeloma/drug therapy , Multiple Myeloma/pathology , Tomography, X-Ray Computed , Vincristine/administration & dosageABSTRACT
The QM-1 strain of Marek's disease virus (MDV) isolated from Japanese quail (JQ) induced higher mortality (96%) with MD lesions in quail than the JM strain of MDV isolated from chickens (C) (21%). In contrast both viruses induced MD in 90% of chickens. Pathological changes produced in quail inoculated with JQ-MDV or C-MDV were similar. However, the incidence of tumour lesions in the duodenum of quail inoculated with JQ-MDV was significantly higher. Neither virus induced tumour lesions in the duodenum of chickens. Appearance of viraemia in quail inoculated with MDV was delayed and its level was low as compared with chicken cases. MDV antigens in feather tips appeared in quail inoculated with JQ-MDV but not with C-MDV. No MDV was recovered from the MDV-inoculated quail by direct kidney cell cultures, although MDV was recovered by subpassage of the cultures into chicken embryo fibroblasts. No antibodies were detected in the affected quail by agar gel precipitation test.
