Thyroid involvement by laryngeal cancer among Iranian patients.

OBJECTIVE: Asian patients with laryngeal cancer have been reported to have a high prevalence of thyroid involvement. This study aimed to investigate the prevalence of thyroid invasion in Iranian patients with laryngeal cancer. METHODS: Hospital records for all patients with a definite diagnosis of laryngeal cancer between 1996 and 2009 (351 patients) were reviewed, and the prevalence of thyroid invasion was established based on the pathology report at the time of surgery. RESULTS: Thyroid invasion was found in 16 patients (4.55 percent), and was limited to one thyroid lobe in two-thirds of cases. All instances of thyroid invasion occurred in patients with stage III (81.25 percent) or IV (18.75 percent) cancer. No case of metastasis was reported. The glottic region was identified as the tumour origin in most cases of thyroid invasion (56.25 percent). CONCLUSION: Most cases of thyroid invasion by laryngeal cancer occurred in cancer stage III, at grades G1 and G2, among male patients, and arose from tumours of the glottic region.

Maternal progesterone level in fetal growth restriction and its relationship with Doppler velocimetry indices.

BACKGROUND/OBJECTIVE: To verify whether progesterone concentration is changed in the maternal serum of intra-uterine growth retardation (IUGR) pregnancies and to assess if there is a relationship between maternal progesterone and fetal Doppler velocimetry. PATIENTS AND METHODS: Thirty-five patients with intrauterine growth retardation infants and thirty-seven pregnant women with appropriate for gestational age (AGA) fetuses were enrolled in the study. Maternal progesterone serum was determined. Doppler velocimetry of umbilical and middle cerebral arteries (MCA) were obtained in all fetuses. RESULTS: Maternal progesterone level in IUGR infants (58.49±7.06 ng/ml) had no significant difference with AGA fetuses (58.13±7.87 ng/ml) (p=0.96). In the IUGR group, umbilical artery resistive index (RI), pulsatility index (PI) and systolic/diastolic (S/D) ratio were higher than the normal group (p<0.001), and MCA RI (p value=0.014) and PI (p=0.012) were significantly less than the IUGR group. Besides, RI C/U in the IUGR group was significantly less than the normal group (p<0.001). A negative significant correlation was detected between maternal progesterone level and MCA PI (r=-0.38) and RI (r=-0.38) in the AGA group. CONCLUSION: It seems that progesterone has no effect on fetal placental circulation and serum progesterone can not discriminate IUGR infants from AGA infants. Progesterone is a poor marker for placental dysfunction.

Coronary heart disease and associated risk factors in Qazvin: a population-based study.

In a cross-sectional study in Qazvin, Islamic Republic of Iran, 846 residents (425 men and 421 women) aged > or = 25 years were assessed for coronary heart disease and its associated risk factors comparing ischaemic and non-ischaemic groups. The age-adjusted prevalence of possible myocardial infarction, ischaemic ECG changes and angina pectoris were 4.2%, 36.8% and 2.2% respectively. There was no difference in the mean systolic and diastolic blood pressure and body mass index between ischaemic and non-ischaemic groups. There was a significant association between possible myocardial infarction and hypertension, type 2 diabetes, and smoking in women. There was also a significant association between ischaemic ECG changes and waist-hip ratio in women and between ischaemic ECG changes and hypertension in men.

Coronary heart disease and associated risk factors in Qazvin: a population-based study

In a cross-sectional study in Qazvin, Islamic Republic of Iran, 846 residents [425 men and 421 women] aged >/= 25 years were assessed for coronary heart disease and its associated risk factors comparing ischaemic and non-ischaemic groups. The age-adjusted prevalence of possible myocardial infarction, ischaemic ECG changes and angina pectoris were 4.2%, 36.8% and 2.2% respectively. There was no difference in the mean systolic and diastolic blood pressure and body mass index between ischaemic and non-ischaemic groups. There was a significant association between possible myocardial infarction and hypertension, type 2 diabetes, and smoking in women. There was also a significant association between ischaemic ECG changes and waist'hip ratio in women and between ischaemic ECG changes and hypertension in men

Laparoscopic management of an internal double omental hernia: a rare cause of intestinal obstruction.

INTRODUCTION: Internal hernia is a very rare cause of intestinal obstruction (0.2-0.9% of cases), associated with 45% mortality. A review of the literature revealed just eight reported cases of double omental hernia since 1950 of which our patient is the first case successfully treated laparoscopically. CASE PRESENTATION: We report on a 29-year-old man who presented with signs and symptoms of intestinal obstruction. The patient underwent emergent exploratory laparoscopy. This revealed herniation of a 20-cm jejunal loop through the gastrocolic ligament and reemergence through a defect in the gastrohepatic ligament. The strangulated loop was reduced with slight traction, and the defect was repaired. The patient was discharged from hospital in just 5 days' time, and after 6 months of follow-up, the general condition of the patient was normal. CONCLUSIONS: Laparoscopy is a good technique with minimal complications compared with laparotomy. As many cases are missed due to nonspecific signs and symptoms, an urgent laparoscopy or laparotomy is highly recommended in such a situation.

Epidemiologic analysis of the Tehran Cancer Institute Data System Registry (TCIDSR).

OBJECTIVE: To review epidemiological data on thyroid cancer in Iran. METHODS: The Tehran Cancer Institute Data System Registry (TCIDSR) was used to identify patients with different histological types of thyroid cancer (TC) in Iran. Data were analysed from 438 thyroid cancer cases identified by the TCIDSR in 1998-99. Disease prevalence was calculated with reference to age, time and place. RESULTS: The TCIDSR recorded 438 primary malignancies of the thyroid gland: papillary, follicular, medullary, and anaplastic carcinomas accounted for 67.1%, 10.7%, 5.3% and 4.3% of cases, respectively. The remaining 12.6% were classified as OD (other diagnoses). The prevalence of TC was highest in ethnic Farsis. The age range of patients was 8-85 years. Mean patient age was 44.52+17.03 years (mean + SD) overall, 47.74+18.10 years in female patients and 43.04+16.34 years in male patients. Anaplastic (6.5% vs. 3.3%) and medullary (10.0% vs. 3.0%) cancers were more common in men than women. CONCLUSION: This study was undertaken to define the epidemiological aspects of thyroid carcinoma in Iran, an area of endemic iodine deficiency until fairly recently. Against expectation for an iodine-deficient area, the frequency distribution of tumours in our study was closer to that seen in iodine-rich areas. Additional research on the risk factors for thyroid cancer--genetic, ethnic, geographic and environmental--is needed to explain the high incidence of PTC overall, and among ethnic Farsis in particular, in Iran.