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1.
Ann Dermatol Venereol ; 144(4): 263-267, 2017 Apr.
Article in French | MEDLINE | ID: mdl-28325515

ABSTRACT

INTRODUCTION: This article introduces a new case of Rowell's syndrome, a controversial entity defined by the association of lupus erythematosus and erythema multiforme. OBSERVATION: A 43-year-old woman was diagnosed with lupus erythematosus induced by esomeprazole. Because her eruption did not improve after withdrawal of the drug, hydroxychloroquine was administered. Two weeks later, the patient described new annular lesions on her chest and arms, both erosive and crusted, and some had a target-like appearance. The oral mucosa was also affected. Histology revealed sub-epidermal blistering with keratinocytic necrosis, strongly suggesting erythema multiforme. Screening for other causes of erythema multiforme proved negative. A positive outcome was achieved with corticosteroids and hydroxychloroquine. One year later, the patient was in complete remission for both lupus erythematosus and erythema multiforme. DISCUSSION: The association of lupus erythematosus and erythema multiforme first described in 1963 is known as Rowell's syndrome. While diagnostic criteria have been established in the literature, the reality of this entity is still contested. The annular lesions of subacute lupus erythematosus may be confused with the lesions of erythema multiforme. As suggested in the above section, other authors consider Rowell's syndrome to be a singular entity. Indeed, our patient developed lesions distinct from those initially suggesting subacute lupus erythematosus, in particular: the target-like aspect of the elementary lesions, mucosal involvement, a distinct histological aspect, and dissociated outcomes. Ultimately, the definition of Rowell's syndrome remains highly debated.


Subject(s)
Erythema Multiforme/pathology , Lupus Erythematosus, Cutaneous/pathology , Adrenal Cortex Hormones/therapeutic use , Adult , Anti-Ulcer Agents/adverse effects , Cheilitis/etiology , Diagnosis, Differential , Erythema Multiforme/diagnosis , Erythema Multiforme/drug therapy , Esomeprazole/adverse effects , Female , Humans , Hydroxychloroquine/therapeutic use , Lupus Erythematosus, Cutaneous/chemically induced , Lupus Erythematosus, Cutaneous/drug therapy , Syndrome
2.
Rev Med Interne ; 37(9): 632-5, 2016 Sep.
Article in French | MEDLINE | ID: mdl-26971970

ABSTRACT

INTRODUCTION: Granulomatosis with polyangiitis is a systemic and necrotizing vasculitis, and cutaneous involvement is uncommon. We report two cases of skin ulceration mimicking a pyoderma gangrenosum, and revealing granulomatosis with polyangiitis. CASE REPORTS: We report two patients who presented with atypical cutaneous ulcerations, with a chronic course. These wounds were large ulcerations with abrupt edges, with purulent and hemorrhagic exudates. The first hypothesis was a pyoderma gangrenosum, but the biopsies were not specific. New biopsies performed distant from the edges showed a necrotizing vasculitis associated with giant cells granuloma, typical from granulomatosis with polyangiitis. CONCLUSION: Cutaneous manifestations are uncommon in granulomatosis with polyangiitis, and can be misleading as they may precede the systemic symptoms. We report two cases of granulomatosis with polyangiitis revealed by cutaneous symptoms mimicking a pyoderma gangrenosum. Repetition of the skin biopsies were necessary to obtain the diagnosis.


Subject(s)
Granulomatosis with Polyangiitis/diagnosis , Pyoderma Gangrenosum/diagnosis , Skin Ulcer/diagnosis , Skin/pathology , Aged , Biopsy , Diagnosis, Differential , Female , Granulomatosis with Polyangiitis/complications , Humans , Male , Middle Aged
3.
Ann Dermatol Venereol ; 142(4): 281-4, 2015 Apr.
Article in French | MEDLINE | ID: mdl-25683016

ABSTRACT

INTRODUCTION: White lentiginosis is characterized by white guttate macules with a typical histological structure: lentiginosis hyperplasia with hypopigmentation. OBSERVATION: A 23-year-old woman, from Algeria, presented with white macules from 5 years ago. Few women in her family had the same trouble. Cutaneous examination revealed diffused white little macules. Histological examination showed a lentiginous hyperplasia of the epidermis, with elongated club-shaped rete ridges and an unusual loss of pigmentation. DISCUSSION: Different diagnosis should be discussed with disseminated leucoderma macules. Nevertheless, the only one which corresponds with our case is the white lentiginosis. To our knowledge, it is the first case described since Grosshans et al. in 1994. Our patient is a descendant of the original case's family. This new case appears to confirm the genetic origin of the disorder and suggests autosomal dominant or X-linked inheritance.


Subject(s)
Hypopigmentation/diagnosis , Lentigo/diagnosis , Algeria/ethnology , Diagnosis, Differential , Female , Humans , Hypopigmentation/genetics , Hypopigmentation/pathology , Lentigo/genetics , Lentigo/pathology , Skin Pigmentation , Young Adult
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