ABSTRACT
OBJECTIVE: To determine the common hematological abnormalities in HIV infected children and any association of these abnormalities with HIV disease severity. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Regional Pediatric ART centre, Medical College and Hospital, Kolkata, West Bengal, India, from November 2011 to November 2012. METHODOLOGY: Children up to 12 years with confirmed diagnosis of HIV infection were clinically examined and tested for complete hemogram and CD4 count. Bone marrow study was done in selected patient depending on hemogram report. Children were divided in different stages according to WHO clinical staging. Each of the hematological parameters was assessed for any association with progression of disease. Fisher's Exact Test was used for determining the association between WHO clinical staging and abnormal blood parameters. P-value < 0.05 was taken as significant. RESULTS: Sixty nine percent of the study population was anemic; 47.37% (18/38), 66.67% (8/12), 71.43% (15/21) and 93.10% (27/29) of stage 1, 2, 3 and 4 respectively were anemic in the study population (p=0.001). Leucopenia was present in 34% (34/100) children. Neutropenia and lymphopenia was present in 19% (19/100) and 22% (22/100) children. Lymphopenia was present in 7.89% (3/38), 16.67% (2/12), 19.05% (4/21) and 44.83% (13/29) of patient with stage 1, 2, 3 and 4 respectively (p=0.020). Eosinophilia was present in 17% (17/100) and thrombocytopenia in 11% (11/100) children. 2 patients with stage 4 disease were with hypoplastic bone marrow. CONCLUSION: Anemia was the most common hematological abnormality in HIV infected children. Anemia and lymphopenia had a significant association with the stage of the disease.
Subject(s)
HIV Infections/complications , Hematologic Diseases/complications , Adolescent , Anemia/epidemiology , Blood Cell Count , Bone Marrow/pathology , CD4 Lymphocyte Count , Child , Child, Preschool , Cross-Sectional Studies , Female , HIV Infections/blood , HIV Infections/diagnosis , HIV Infections/epidemiology , Hematologic Diseases/blood , Hematologic Diseases/epidemiology , Humans , India/epidemiology , Infant , MaleABSTRACT
Systemic Lupus Erythematosus (SLE) may have different neurological manifestations. Mononerits multiplex is the most common type of peripheral nervous system involvement in adult population, but case reports in pediatric population are sparse. We are reporting a case of pediatric SLE, presenting with polyarthritis and subsequently developing mononeuritis multiplex, identified by NCV.
Subject(s)
Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , Mononeuropathies/complications , Mononeuropathies/diagnosis , Child , Female , HumansABSTRACT
To identify the aetiology and outcome of congestive heart failure in children, a prospective study was carried out in the department of paediatric medicine, Medical College, Kolkata among 0-12 years children with documented signs and symptoms of heart failure. Proper history taking, physical examination, chest x-ray, ECG, echocardiography and maintenance of management records were done. A total of 350 cases were enrolled. Congenital heart disease was seen in 34% cases and the rest were due to acquired heart disease. Anaemia was detected in 17.4% cases. Mortality was 2.85%.
