Markov Logic Networks for Adverse Drug Event Extraction from Text.

Adverse drug events (ADEs) are a major concern and point of emphasis for the medical profession, government, and society. A diverse set of techniques from epidemiology, statistics, and computer science are being proposed and studied for ADE discovery from observational health data (e.g., EHR and claims data), social network data (e.g., Google and Twitter posts), and other information sources. Methodologies are needed for evaluating, quantitatively measuring, and comparing the ability of these various approaches to accurately discover ADEs. This work is motivated by the observation that text sources such as the Medline/Medinfo library provide a wealth of information on human health. Unfortunately, ADEs often result from unexpected interactions, and the connection between conditions and drugs is not explicit in these sources. Thus, in this work we address the question of whether we can quantitatively estimate relationships between drugs and conditions from the medical literature. This paper proposes and studies a state-of-the-art NLP-based extraction of ADEs from text.

Extracting Adverse Drug Events from Text using Human Advice.

Adverse drug events (ADEs) are a major concern and point of emphasis for the medical profession, government, and society in general. When methods extract ADEs from observational data, there is a necessity to evaluate these methods. More precisely, it is important to know what is already known in the literature. Consequently, we employ a novel relation extraction technique based on a recently developed probabilistic logic learning algorithm that exploits human advice. We demonstrate on a standard adverse drug events data base that the proposed approach can successfully extract existing adverse drug events from limited amount of training data and compares favorably with state-of-the-art probabilistic logic learning methods.