[Changes in indicators of external and internal secretion of the pancreas during treatment of chronic pancreatitis of alcoholic etiology with somatostatin analogs]. / Izmenenie pokazatelei vneshnei i vnutrennei sekretsii podzheludochnoi zhelezy pri lechenii khronicheskogo pankreatita alkogol'noi étiologii analogom somatostatina.

AIM: To study somatostatin (SS) content in patients with chronic pancreatitis (CP) and effects of sandostatin (a synthetic analogue of SS) on endo- and exocrine pancreatic functions in CP patients. MATERIAL AND METHODS: SS plasma levels were measured by radioimmunoassay in basal conditions in 32 CP patients. Sandostatin treatment was given to 20 patients with CP of alcohol etiology (twice a day subcutaneously for 5 days). In the course of the treatment the following indices were measured: serum trypsin, amilase, lipase, alpha 2-macroglobulin, general antitryptic activity, blood immunoreactive insulin in basal conditions and after intravenous injection of glucose. RESULTS: SS levels in peripheral blood were elevated in patients with complicated alcoholic CP. Sandostatin in CP used for 5 days had no significant impact on insulin secretion, levels of pancreatic enzymes, inhibiting system of blood. 90% patients with alcoholic CP experienced relief of pain which may relate to suppression of stimulated secretion of gastrointestinal hormones as well as to a favourable action of sandostatin on stabilization of membranes of acinar cells. CONCLUSION: Sandostatin administration in CP patients is justified and is especially recommended in the complicated course.

[Hormonal regulation of calcium metabolism in chronic alcoholic pancreatitis]. / Gormonal'naia reguliatsiia obmena kal'tsiia pri khronicheskom alkogol'nom pancreatite.

The purpose of this investigation is to study the state of Ca regulation mechanism at chronic alcohol pancreatitis and to compare with the activity changes of pancreatic lipase and its inhibitor at this disease. Content of Ca and regulating hormones (parathormone and calcitonin), activity of pancreas lipase and inhibitory blood ability in connection with it were determined in 30 patients with chronic alcohol pancreatitis without complications and in 20 persons with complicated disease course. Ca blood content fluctuates within normal level. But the median Ca contents in the group of patients with complications were significantly higher than in the control group. No changes in the level of pathormones and the increased Ca content were observed in the blood of the patients. The direct correlation between Ca and calcitonin and inverse correlation between Ca and parathormone were kept. According to correlation analysis of definite indexes the regulatory mechanisms of Ca metabolism in patients were intact. The increased calcitonin blood content in patients with chronic alcohol pancreatitis has apparently a compensatory character. This fact is confirmed by direct correlation with inhibitory ability of blood with respect to lipase.

[Effect of sandostatin on the functional status of the pancreas in patients with chronic pancreatitis]. / Vliianie sandostatina na funktsional'noe sostoianie podzheludochnoi zhelezy u bol'nykh khronicheskim pankreatitom.

Taking into account the ability of somatostatin to exert influence of the endocrine and exocrine functions of the pancreas, the object of this research is to study the somatostatin content in patients with chronic pancreatitis and the impact of treatment with its synthetic analog, sandostatin, on the endocrine and exocrine functions of the pancreas in patients with chronic pancreatitis.

[Stenting pancreatic ducts as a method of selecting treatment and prevention of pancreatitis]. / Stentirovanie pankreaticheskogo protoka kak methoda vybora lecheniia i profilaktiki pankreatita.

According to the literature, the method of stents in the pancreatic ducts is a highly efficient and promising method for treatment of separate forms of pancreatitis. It is also an alternative to surgery.

[The role of phospholipase A2 in pathogenesis of acute and chronic pancreatitis, its significance in diagnosis of the disease]. / Rol' fosfolipasy A 2 v patogeneze ostrogo i khronicheskogo pankreatitov, ee znachenie v diagnostike étikh zabolevanii.

The literary data concerning phospholipase A2 (PHL2) significance in pathogenesis of acute and chronic pancreatitis and pancreonecrosis development are presented in this paper. Isoforms of PHL2, that are responsible for morphological changes in the patients with chronic pancreatitis were described. The great significance of PHL2 activity for diagnosis of acute and chronic pancreatitis was demonstrated.