ABSTRACT
The study evaluated the ability of the alcohol extract of Butea frondosa to protect the gastro-duodenal lining from injury inflicted by acetic acid and pyloric ligation in rats. The induced gastric lesions lead to the generation of alkaline phosphatase and pepsin, which serve as important markers of gastric damage. Alcohol extract of Butea frondosa was administered in doses of 10, 100, 300 and 500 mg/kg as a single schedule and for the time dependent studies in a dose of 100 mg/kg for 7, 14, 21 and 28 days, respectively. Our studies reveal a decline in the formation of alkaline phosphatase and pepsin with 300 and 500 mg/kg of the extract and following treatment for 21 and 28 days, respectively. Extract of Butea frondosa produces significant diminution in the formation of gastric markers implying possible gastro-protective action.
ABSTRACT
The study evaluated the antidiarrhoeal property of the alcohol extract of Butea frondosa leaf on mice and rats. Studies revealed that at a dose of 25 and 75 mg/kg a considerable reduction in the extent of diarrhoea was observed but at a dose of 100 mg/kg the animals appeared completely constipated when subjected to castor oil induced diarrhoea and intestinal motility model. Therefore, Butea frondosa can be regarded as an effective antidiarrhoeal.
ABSTRACT
The synthesis of some 4-(arylsydnonyl)-2-(4-arylhydrazono-3-methyl-5-oxo-2-pyrazolin-1-yl)- thiazoles by reacting 1-thiocarboxamido-3-methyl-4-(aryihydrazono)-2-pyrazolin-5-ones with different 4-bromoacetyl-3-arylsydnones is described. A few compounds from this series were screened for their anti-inflammatory, analgesic, and CNS depressant activities. Among the tested compounds 6s, 6d, 6n, and 6u showed significant anti-inflammatory activity comparable with that of standard drug Ibuprofen. Compounds containing chlorine and carboxylic substituents are more active. 6f, 6r, and 6u showed marked analgesic activity and most of the compounds tested showed promising CNS depressant activity comparable with that of standard drug pentobarbitone.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Central Nervous System Depressants/chemical synthesis , Sydnones/chemical synthesis , Analgesia , Animals , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Central Nervous System Depressants/chemistry , Central Nervous System Depressants/pharmacology , Female , Male , Mice , Rats , Sleep/drug effects , Structure-Activity Relationship , Sydnones/chemistry , Sydnones/pharmacologyABSTRACT
A Series of 4-(1-Aryl-5-oxo-2-phenyl-2-imidazolin-4-yl) metheno-5-chloro-3-methyl-1-phenyl-3-pyrazole) were synthesised and tested for their antibacterial, antiinflammatory and analagesic activities. Some of the compounds showed significant antiinflammatory properties.
Subject(s)
Analgesics, Non-Narcotic/chemical synthesis , Analgesics, Non-Narcotic/pharmacology , Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Imidazoles/chemical synthesis , Imidazoles/pharmacology , Animals , Bacteria/drug effects , Mice , Microbial Sensitivity Tests , Pain Measurement/drug effectsABSTRACT
Several new 1,3,4-thiadiazolo[2,3-c]-as-triazines were synthesized by the reaction of 6-substituted-4-amino-3-mercapto-1,3,4-triazon-5 (4H)-ones with appropriate aromatic and heterocyclic carboxylic acids in the presence of phosphorus oxychloride. The structures of the newly synthesized compounds were established on the basis of analytical, IR, NMR and mass spectral data. Some selected compounds from this series were subjected to both antimicrobial and pharmacological studies.
