1.
Org Lett
; 12(5): 1012-4, 2010 Mar 05.
Article
in English
| MEDLINE
| ID: mdl-20143842
ABSTRACT
When gamma,delta-epoxy-alpha,beta-unsaturated esters or amides were treated with 2 equiv of Grignard reagents in the presence of 10-24 mol % FeCl(2), regio- and stereoselective substitution of the epoxide moiety with the Grignard reagent occurred to give exclusively delta-hydroxy-gamma-alkyl or aryl-alpha,beta-unsaturated esters or amides in good yields.