1.
Chem Sci
; 13(27): 8080-8087, 2022 Jul 13.
Article
in English
| MEDLINE
| ID: mdl-35919435
ABSTRACT
We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf that proceeds through the formation of N-C, O-C and C-C bonds providing a simple synthetic protocol for obtaining 2,4,5-trisubstituted oxazoles.