Subject(s)
Hemangioma, Cavernous/diagnostic imaging , Mandibular Condyle/diagnostic imaging , Mandibular Neoplasms/diagnostic imaging , Temporomandibular Joint Disorders/diagnostic imaging , Adult , Female , Hemangioma, Cavernous/pathology , Hemangioma, Cavernous/surgery , Humans , Mandibular Condyle/pathology , Mandibular Condyle/surgery , Mandibular Neoplasms/pathology , Mandibular Neoplasms/surgery , Neoplasm Invasiveness , Radiography, Panoramic , Temporomandibular Joint/diagnostic imaging , Temporomandibular Joint/pathology , Temporomandibular Joint/surgery , Temporomandibular Joint Disorders/pathology , Temporomandibular Joint Disorders/surgery , Tomography, X-Ray ComputedABSTRACT
Many etiologic agents for Meniére's syndrome have been proposed, suggesting a heterogeneous nature for this disorder. Dissimilar etiologies could, of course, yield disparate responses to uniform treatment. Although electrocochleography has provided us with some objective diagnostic criteria, the actual identification of Meniére's syndrome rests predominantly on clinical criteria. Several of our patients with dysautonomia presented with classical symptoms of Meniére's syndrome. Twenty-five of these patients were treated with increased fluid and sodium intake and flurocortisone, a mineralcorticoid agent. Our favorable results have led us to postulate a heretofore unrecognized etiology for Meniére's syndrome, and speculate on some of the previously reported responses of Meniére's syndrome to corticosteroid treatment.
Subject(s)
Autonomic Nervous System Diseases/complications , Meniere Disease/etiology , Audiometry, Evoked Response , Autonomic Nervous System Diseases/diagnosis , Blood Pressure , Dizziness , Electrocardiography , Female , Fluid Therapy , Humans , Male , Meniere Disease/diagnosis , Meniere Disease/therapy , Mineralocorticoids/therapeutic use , Nystagmus, Pathologic/complications , Sodium/therapeutic use , Valsalva Maneuver , Water-Electrolyte ImbalanceABSTRACT
This study was motivated by the need to develop new methods to predict tumor response to chemotherapeutic agents. Using implantable cell-growth chambers, squamous carcinoma cells from head and neck tumors were xenografted into the peritoneal cavity of immunocompetent rats. Animals were divided into control and treatment groups. The treatment groups received intravenous cisplatin (CDDP) or 5-fluorouracil (5-FU) v normal saline solution for the control. Animals from each group were randomly selected and killed on days 3, 5, and 7 postimplantation. The chambers were retrieved, the media aspirated, and cells counted. Exponential growth curves were derived for the control and treatment groups. Statistically significant growth inhibition was observed for both treatment arms, compared with controls. This method of chemosensitivity testing proved to be inexpensive and reliable, and demonstrated tumor cell killing by 5-FU and CDDP.
