Evolution and present scenario of multifunctionalized mesoporous nanosilica platform: A mini review.

The development of nanomaterials in the field of biomedical has attracted much attention in the past decades. New mesoporous nanosilica (MNS) generation, called multi functionalized MNS, presents the promising applications for efficient encapsulation, controlled release, and intracellular delivery of therapeutic agents due to their unique physiochemical properties, such as large surface area and pore volume, tunable particle size, biocompatibility, and high loading capacity. In this review, we intensively discussed the multi functionalized MNSs that respond to the demand of physical stimuli (thermo, light, magnetic field, ultrasound, and electricity), chemical stimuli (pH, redox, H2O2), and biological stimuli (enzyme, glucose, ATP), individual or in combination. Moreover, the recent applications of multi functionalized MNSs, focusing on drug and other therapeutic agents delivery, diagnostic imaging, and catalysis are also summarized in order to promote the further development of MNSs as a universal platform in the bright upcoming future.

Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery.

Porous nanosilica (PNS) has been regarded as a promising candidate for controlled delivery of anticancer drugs. Unmodified PNS-based nanocarriers, however, showed a burst release of encapsulated drugs, which may limit their clinical uses. In this report, PNS was surface conjugated with adamantylamine (ADA) via disulfide bridges (-SS-), PNS-SS-ADA, which was further modified with cyclodextrin-poly(ethylene glycol) methyl ether conjugate (CD-mPEG) to form a core@shell structure PNS-SS-ADA@CD-mPEG for redox triggered delivery of doxorubicin (DOX), DOX/PNS-SS-ADA@CD-mPEG. The prepared PNS-SS-ADA@CD-mPEG nanoparticles were spherical in shape with an average diameter of 55.5 ± 3.05 nm, a little larger than their parentally PNS nanocarriers, at 49.6 ± 2.56 nm. In addition, these nanoparticles possessed high drug loading capacity, at 79.2 ± 3.2%, for controlled release. The release of DOX from DOX/PNS-SS-ADA@CD-mPEG nanoparticles was controlled and prolonged up to 120 h in PBS medium (pH 7.4), compared to less than 40 h under reducing condition of 5 mM DTT. Notably, the PNS-SS-ADA@CD-mPEG was a biocompatible nanocarrier, and the toxicity of DOX was dramatically reduced after loading drugs into the porous core. This redox-sensitive PNS-SS-ADA@CD-mPEG nanoparticle could be considered a potential candidate with high drug loading capacity and a lower risk of systemic toxicity.