Examining health apps and wearable use in improving physical and mental well-being across U.S., China, and Singapore.

Health apps and wearables are touted to improve physical health and mental well-being. However, it is unclear from existing research the extent to which these health technologies are efficacious in improving physical and mental well-being at a population level, particularly for the underserved groups from the perspective of health equity and social determinants. Also, it is unclear if the relationship between health apps and wearables use and physical and mental well-being differs across individualistic, collectivistic, and a mix of individual-collectivistic cultures. A large-scale online survey was conducted in the U.S. (individualist culture), China (collectivist culture), and Singapore (mix of individual-collectivist culture) using quota sampling after obtaining ethical approval from the Institutional Review Board (IRB-2021-262) of Nanyang Technological University (NTU), Singapore. There was a total of 1004 respondents from the U.S., 1072 from China, and 1017 from Singapore. Data were analyzed using multiple regression and negative binomial regression. The study found that income consistently had the strongest relationship with physical and mental well-being measures in all three countries, while the use of health apps and wearables only had a moderate association with psychological well-being only in the US. Health apps and wearables were associated with the number of times people spent exercising and some mental health outcomes in China and Singapore, but they were only positively associated with psychological well-being in the US. The study emphasizes the importance of considering the social determinants, social-cultural context of the population, and the facilitating conditions for the effective use of digital health technologies. The study suggests that the combined use of both health apps and wearables is most strongly associated with better physical and mental health, though this association is less pronounced when individuals use only apps or wearables.

Effects of oxytetracycline on variation in intracellular and extracellular antibiotic resistance genes during swine manure composting.

This research aimed to investigate the alterations in extracellular (eARGs) and intracellular (iARGs) antibiotic resistance genes in response to oxytetracycline (OTC), and unravel the dissemination mechanism of ARGs during composting. The findings revealed both low (L-OTC) and high contents (H-OTC) of OTC significantly enhanced absolute abundance (AA) of iARGs (p < 0.05), compared to CK (no OTC). Composting proved to be a proficient strategy for removing eARGs, while AA of eARGs was significantly enhanced in H-OTC (p < 0.05). OTC resulted in an increase in AA of mobile genetic elements (MGEs), ATP levels, antioxidant and DNA repair enzymes in bacteria in compost product. Structural equation model further demonstrated that OTC promoted bacterial DNA repair and antioxidant enzyme activities, altered bacterial community and enhanced MGEs abundance, thereby facilitating iARGs dissemination. This study highlights OTC can increase eARGs and iARGs abundance, underscoring the need for appropriate countermeasures to mitigate potential hazards.

Effects of biochar-derived dissolved organic matter on the gut microbiomes and metabolomics in earthworm Eisenia fetida.

The ecological risks of biochar-derived dissolved organic matter (DOM) to soil invertebrates at different organismal levels remains limited. This study comprehensively explored the ecological risks of biochar-derived DOM on earthworm gut through assessments of enzyme activity response, histopathology, gut microbiomes, and metabolomics. Results demonstrated that DOM disturbed the digestive enzymes in earthworm, especially for 10% DOM300 groups. The integrated biomarker response v2 (IBRv2) indicated that the perturbation of earthworm digestive enzymes induced by DOM was both time-dependent and dose-dependent. Pathological observations revealed that 10% DOM300 damaged intestinal epithelium and digestive lumen of earthworms. The significant damage and injury to earthworms caused by DOM300 due to its higher concentrations of heavy metal ions and organic substrates (e.g., toluene, hexane, butanamide, and hexanamide) compared to DOM500 and DOM700. Analysis of 16S rRNA from the gut microbiota showed a significant decrease in genera (Verminephrobacter, Bacillus, and Microbacteriaceae) associated with inflammation, disease, and detoxification processes. Furthermore, 10% DOM300 caused the abnormality of metabolites, such as glutamate, fumaric acid, pyruvate, and citric acid, which were involved in energy metabolism, These findings contributed to improve our understanding of the toxic mechanism of biochar DOM from multiple perspectives.

Examining Antecedents of Factual Knowledge and Perceived Familiarity of COVID-19 Contact Tracing App: A Modified Cognitive Mediation Model.

This study employs a modified cognitive mediation model to investigate the role of health valuation and fear in shaping media attention, factual knowledge, and perceived familiarity with COVID-19 contact tracing apps. Data were collected from a national survey of 906 Singaporeans, and structural equation modeling was used to analyze the results. Findings indicated that both fear of COVID-19 and health valuation were positively associated with newspapers, television, and social media attention, with health valuation demonstrating a stronger association with each media type. This suggests that health valuation, as an intrinsic motivation, is more critical in information-seeking behavior related to emerging health technologies. However, media attention on all platforms did not correlate with factual knowledge of COVID-19 contact tracing apps, whereas attention to social media was positively associated with perceived familiarity with these apps. This result highlights the potential influence of social media in shaping public perceptions, warranting further investigation into the quality and accuracy of the information disseminated. News elaboration was found to have a positive association with both factual knowledge and perceived familiarity with COVID-19 contact tracing apps. This underscores the need for effective communication strategies to promote accurate understanding of health technologies and emphasizes the role of individual motivations in shaping media consumption and information processing.

Examining Theoretical Frameworks and Antecedents of Health Apps and Wearables Use: A Scoping Review.

The advancement of health apps and wearables has garnered substantial academic attention, particularly in examining why individuals decide to use or not use them. In response to the extensive body of research on this topic, we conducted a scoping review of 61 articles published from 2007 to 2022, aiming to examine the dominant theoretical frameworks and antecedents of health apps and wearables use. The findings demonstrated that the dominant theoretical frameworks within this domain were rooted in the human-computer interaction theories, notably the Technology Acceptance Model and the Unified Theory of Acceptance and Use of Technology. Next, our review identified four levels of antecedents: technological, individual, societal, and policy. At the technological level, emphasis was placed on functionality, reliability, and technological infrastructure. Individual antecedents encompassed socio-demographics, personality traits, cognitive responses to benefits and risks, emotional and affective responses, self-efficacy, and digital literacy. Societal antecedents highlighted the role of social networks and social norms, while policy antecedents elaborated on laws, regulations, and guidelines that encouraged health technology adoption. Our discussion illuminated that the evolving trend of theoretical frameworks in health apps and wearables use research, initially rooted in human-computer interaction, is progressively moving toward more comprehensive perspectives. We further underscored the importance of delving into societal and policy antecedents, which often are overshadowed by the more commonly discussed technological and individual factors. In conclusion, we advocated for a multi-stakeholder collaborative network approach, as this would enable communication researchers to understand the use of health apps and wearables more comprehensively.

Enhancing Community Participation in Dengue Control Through Digital Crowdsourcing: An Analysis of a World Mosquito Program Digital Open Call in Sri Lanka.

BACKGROUND: Two crowdsourcing open calls were created to enhance community engagement in dengue control in Sri Lanka. We analyzed the process and outcomes of these digital crowdsourcing open calls. METHODS: We used standard World Health Organization methods to organize the open calls, which used exclusively digital methods because of coronavirus disease 2019 (COVID-19). We collected and analyzed sociodemographic information and digital engagement metrics from each submission. Submissions in the form of textual data describing community-led strategies for mosquito release were coded using grounded theory. RESULTS: The open calls received 73 submissions. Most people who submitted ideas spoke English, lived in Sri Lanka, and were 18 to 34 years old. The total Facebook reach was initially limited (16 161 impressions), prompting expansion to a global campaign, which reached 346 810 impressions over 14 days. Diverse strategies for the distribution of Wolbachia-infected mosquito boxes were identified, including leveraging traditional festivals, schools, and community networks. Fifteen submissions (21%) suggested the use of digital tools for monitoring and evaluation, sharing instructions, or creating networks. Thirteen submissions (18%) focused on social and economic incentives to prompt community engagement and catalyze community-led distribution. CONCLUSIONS: Our project demonstrates that digital crowdsourcing open calls are an effective way to solicit creative and innovative ideas in a resource-limited setting.

Simultaneous passivation of heavy metals and removal of antibiotic resistance genes by calcium peroxide addition during sewage sludge composting.

This research evaluated the effects of calcium peroxide (CP) at 0% (CK, w/w), 5% (T1, w/w), and 10% (T2, w/w), on heavy metals (HMs) mobility and prevalence of antibiotic resistance genes (ARGs) during sludge composting. T1 and T2 significantly reduced (p < 0.05) the mobility of Cu (29.34%, and 32.94%, respectively), Ni (24.07%, and 31.48%, respectively) and Zn (33.28%, and 54.11%, respectively) compared to CK after the composting. CP addition resulted in a decrease in mobile genetic elements (MGEs) and ARGs during composting. Together with structural equation model and random forest analysis depicted MGEs had a primary association with total ARGs variations during composting. Microbial analysis indicated CP downregulated the expression of the genes associated with two-component and type IV secretion system, thus reducing the prevalence of ARGs. This study demonstrates that application of CP is a feasible strategy to mitigate both ARGs and HMs hazards during composting.

From pandemic to Plandemic: Examining the amplification and attenuation of COVID-19 misinformation on social media.

This study examines the proliferation of COVID-19 misinformation through Plandemic-a pseudo-documentary of COVID-19 conspiracy theories-on social media and examines how factors such as (a) themes of misinformation, (b) types of misinformation, (c) sources of misinformation, (d) emotions of misinformation, and (e) fact-checking labels amplify or attenuate online misinformation during the early days of the pandemic. Using CrowdTangle, a Facebook API, we collected a total of 5732 publicly available Facebook pages posts containing Plandemic-related keywords from January 1 to December 19, 2020. A random sample of 600 posts was subsequently coded, and the data were analyzed using negative binomial regression to examine factors associated with amplification and attenuation. Overall, the extended an extended Social Amplification of Risk Framework (SARF) provided a theoretical lens to understand why certain misinformation was amplified, while others were attenuated. As for posts with misinformation, results showed that themes related to private firms, treatment and prevention of virus transmission, diagnosis and health impacts, virus origins, and social impact were more likely to be amplified. While the different types of misinformation (manipulated, fabricated, or satire) and emotions were not associated with amplification, the type of fact-check labels did influence the virality of misinformation. Specifically, posts that were flagged as false by Facebook were more likely to be amplified, while the virality of posts flagged as containing partially false information was attenuated. Theoretical and practical implications were discussed.

Does the aging behavior of microplastics affect the process of denitrification by the difference of copper ion adsorption?

Riparian sediment is a hot zone for denitrification that can withhold copper and microplastics (MPs) from outside. It has been proven that MPs affect denitrification and the existing forms of copper in the environment. However, the impact of copper on sediment denitrification under exposure to MPs remains unclear. This study revealed the response of sediment denitrification to copper availability under the adsorption of MPs and the complexation of MP-derived dissolved organic matter (DOM). These results showed that MP accumulation inhibited denitrification. However, aged MPs increased the activity of nitrite reductase (12.64%), nitrogen dioxide reductase (37.68%), and electron transport (28.93%) compared with pristine MPs. The aging behavior of MPs alleviated 28.18% nitrite accumulation and 16.41-118.35% nitrous oxide emissions. Thus, the aging behavior of MPs alleviated the inhibition of denitrification. Notably, we resolved the copper ion adsorption and complexation by MPs, MP-derived DOM contributed to the denitrification process, and we found that the key nitrogen removal factors were affected by KL, KM, and K2. These results fill a gap in our understanding of biochemical synthesis of MPs during denitrification. Furthermore, it can be used to build a predictive understanding of the long-term effects of MPs on the sediment nitrogen cycle.

Effects of ferroferric oxide on propionate methanogenesis in sequencing batch reactors: Microbial community structure and metagenomic analysis.

This study investigated the effects of ferroferric oxide (Fe3O4) on propionate methanogenesis in anaerobic sequencing batch reactor (ASBR). Compared to ASBRC (without Fe3O4 addition), the addition of 10 g/L Fe3O4 (ASBRFe) decreased the maximum methane production rate by 69.6 % when propionate was used as the sole substrate. The addition of Fe3O4 reduced the contents of humic substances, riboflavin and nicotinamide adenine dinucleotide in extracellular polymeric substances. Therefore, Fe3O4 inhibited interspecies electron transfer of microorganisms through electronic mediators. Microbial community analysis revealed that Fe3O4 addition increased the relative abundance of acetate oxidizing bacterium (Mesotoga), but decreased the abundance of hydrogenotrophic methanogen (Methanobacterium). Further metagenomics analysis indicated that Fe3O4 increased the abundance of acetate oxidation genes and decreased that of hydrogenotrophic methanogenesis, quorum sensing and V/A-type ATPase genes. Thus, Fe3O4 reduced propionate methanogenesis during anaerobic digestion. The overall results indicate that Fe3O4 addition inhibits methanogenesis for treatment of propionate-contaminated wastewater in ASBR.

Effect of calcium peroxide dosage on organic matter degradation, humification during sewage sludge composting and application as amendment for Cu (II)-polluted soils.

In this research, it was the first time to investigate the effect of two dosages (5% (T1) and 10% (T2), w/w) of calcium peroxide (CP) on organic matter degradation, humification during sewage sludge composting. Additionally, the complexation of Cu to humic substance (HS) derived from CP-compost compared to no CP addition-compost (CK) was also studied. Results showed that compared to CK, T1 and T2 significantly enhanced organic matter degradation and promoted the formation of HS. Two-dimensional correlation Fourier transform infrared spectroscopy (2D-FTIR-COS) and Parallel factor (PARAFAC) analysis revealed that the addition of CP accelerated the synthesis of HS with high aromatization degree and molecular weight than those in CK, owing to the oxidation of small molecules to form carboxyl. The stability constant (log KM) of Cu with CP-derived HS (log KM = 4.22-5.13) indicated a greater complexation ability than CK-derived HS (log KM = 4.05-4.45), due to the faster response of polysaccharides binding to Cu (II) and the higher humification degree of CP-derived HS. This study revealed the potential mechanisms of CP addition on the synthesis of HS and utilization of CP-compost product might provide an effective way to remedy Cu (II)-contaminated soils.

Uptake and accumulation of naphthalene, phenanthrene, and benzo(b)fluoranthene in winter wheat affected by foliar exposure at different growth stages.

Foliar uptake, as an important pathway of polycyclic aromatic hydrocarbons (PAHs) accumulation in winter wheat, has a great contribution to wheat PAHs, which mainly depends on atmospheric PAHs level. An indoor simulation experiment was conducted to explore the effects of foliar exposure to PAHs at different growth stages on PAHs uptake in wheat. Three levels (0, 0.75, 4.5 mg L-1) of mixed solution of three PAHs (Σ3PAHs) including naphthalene (NAP), phenanthrene (PHE), and benzo(b)fluoranthene (BbF) were sprayed on leaves of two varieties (Yunong, YN; Xiaoyan, XY) of winter wheat (Triticum aestivum L.) during the booting, heading, pre-filling, and post-filling stage. The results showed that the sprayed PAHs exhibited little effects on the growth of the two varieties except the stem biomass of YN was significantly (p < 0.05) reduced when high concentration of PAHs was applied at the post-filling stage. PAHs concentration in winter wheat grain was highest under foliar exposure at the pre-filling stage, while the lowest was found under foliar exposure at the post-filling stage. Transfer factor of PAHs from stem to root (TFroot/stem) of three PAHs when foliar exposure to PAHs at the booting and heading stage was significantly (p < 0.001) higher than that at the pre-filling and post-filling stage, while TFgrain/glume of three PAHs when foliar exposure to PAHs at pre-filling stage was significantly (p < 0.01) higher than that at the other three stages. These results indicated that foliar exposure to PAHs during the vegetative growth stage was transferred and distributed to the root, while PAHs are mainly transferred and accumulated to the grain during the grain filling stage. Additionally, the higher lipophilic PAHs showed a lower ability to transfer from the glume to grain, and larger flag leaf area had the potential to promote the enrichment of PAHs in grain. This study indicated that the health risk of PAHs in winter wheat could be effectively reduced by controlling atmospheric PAHs level during pre-filling stage.

Effects of Corn Straw and Citric Acid on Removal of PAHs in Contaminated Soil Related to Changing of Bacterial Community and Functional Gene Expression.

Root exudates can stimulate microbial degradation in rhizosphere, but it is unclear whether the rhizodegradation of polycyclic aromatic hydrocarbons (PAHs) occurs in corn straw-amended soil. Either citric acid or corn straw was added into PAHs-contaminated soil to investigate their effect on the removal of PAHs. Either corn straw (Y) or combined application of corn straw and citric acid (YN100) significantly (p < 0.05) enhanced the removal of soil PAHs by 8.43% and 18.62%, respectively. Both Y and YN100 treatments obviously increased the abundance of PAHs degraders and the potential hosts of PAH-ring hydroxylating dioxygenase (PAH-RHDα) genes. Interestingly, the copies of PAH-RHDα Gram-negative bacteria genes under YN100 treatment was significantly (p < 0.05) higher than those under Y treatment. The present results indicated that combined application of corn straw and citric acid could efficiently enhance the removal of PAHs in soil, mainly via increasing the relative abundances of PAH-degrading bacteria and the expression of PAH-RHDα genes in contaminated soil.

Effects of H3PO4 modified biochar on heavy metal mobility and resistance genes removal during swine manure composting.

In this research, static composting treatments of swine manure with forced ventilation were conducted to study the effects of biochar (BC) and H3PO4 modified biochar (BP) addition on heavy metals (HMs) stabilization, profiles of antibiotic resistance genes (ARGs), heavy metals resistance genes (MRGs) and bacterial communities during swine manure composting. After 42 days of the composting, compared to control (CK), BC and BP decreased the concentration of diethylenetriamine pentaacetic acid extractable Cu and Zn by 12.04%, 15.15% and 26.91%, 36.50%, respectively. Furthermore, BC and BP treatments reduced the total abundances of nine ARGs by 4.02% and 66.21%, and five MRGs by 53.66% and 58.81%, compared to CK in the compost product. Network analysis and square structural equation model analysis revealed that the decrease of ARGs and MRGs in BP treatment was related tothe change in bacterial community during the composting, rather than differences in co-selection pressure.

Response of antibiotic resistance to the co-exposure of sulfamethoxazole and copper during swine manure composting.

Heavy metals driven co-selection of antibiotic resistance in soil and water bodies has been widely concerned, but the response of antibiotic resistance to co-existence of antibiotics and heavy metals in composting system is still unknown. Commonly used sulfamethoxazole and copper were individually and jointly added into four reactors to explore their effects on antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), heavy metal resistance genes (MRGs) and bacterial community structure. The abundance of total ARGs and MGEs were notably decreased by 68.64%-84.95% and 91.27-97.38%, respectively, after the composting. Individual addition of sulfamethoxazole, individual addition of copper, simultaneously addition of sulfamethoxazole and copper increased the abundance of ARGs and MGEs throughout the composting period. Co-exposure of sulfamethoxazole and copper elevated the total abundance of ARGs by 1.17-1.51 times by the end of the composting compared to individual addition of sulfamethoxazole or copper. Network analysis indicated that the shifts in potential host bacteria determined the ARGs variation. Additionally, MGEs and MRGs had significant effects on ARGs, revealing that horizontal gene transfer and heavy metals induced co-resistance could promote ARGs dissemination.

Microbial community competition rather than high-temperature predominates ARGs elimination in swine manure composting.

Aerobic composting is commonly used in pig manure treatment, however, antibiotic resistance genes (ARGs) and their unclear transformation during composting process make the treated manure land using risky. The effects of enhanced thermophilic phase strategy (external heating (HTC) and thermophiles inoculation (MC)) on ARGs removal and the underlying mechanisms were investigated during swine manure composting. HTC increased the total relative abundance (RA) of ARGs by 32.38%, and MC decreased by 21.50% compared to CK by the end of the composting. Mantel test indicated that it was not temperature (P > 0.05), but environmental parameters (pH, Electric Conductivity (EC), etc.) and metabolic products (nitrogen forms) significantly affected the ARGs profile. Partial least-squares path modeling (PLS-PM) suggested that microbial community structure (bacterial abundance and diversities) was the main factor for ARGs evolution. Co-occurrence analysis revealed that HTC could promote the propagation of ARG hosts in later stage of the composting because the strong selection of thermophiles resulted in ecological niches vacancy, and MC enhanced the competition between hosts and nonhosts for ecological niches by increasing thermophiles diversities. These results suggested that competitive inhibition to potential ARGs hosts could be a helpful strategy in ARGs threaten elimination during composting.

Rapid biodegradation of atrazine by a novel Paenarthrobacter ureafaciens ZY and its effects on soil native microbial community dynamic.

An atrazine-utilizing bacterium, designated as ZY, was isolated from agricultural soil and identified as Paenarthrobacter ureafaciens. The P. ureafaciens ZY demonstrated a significant degradation capacity of atrazine, with the degradation efficiency of 12.5 mg L-1 h-1 in liquid media (at pH 7, 30°C, and the atrazine level of 100 mg L-1). The P. ureafaciens ZY contained three atrazine-degrading genes (i.e., trzN, atzB, and atzC) could metabolize atrazine to form cyanuric acid, which showed lower biotoxicity than the parent atrazine as predicted by Ecological Structure Activity Relationships model. A laboratory-scale pot experiment was performed to examine the degradation of atrazine by P. ureafaciens ZY inoculation and investigate its effects on the native microbial communities. The results exhibited that the P. ureafaciens ZY was conductive to the degradation of atrazine, increased the total soil phospholipid fatty acids at the atrazine level of 50, 70, and 100 mg kg-1. By using high-throughput sequencing analysis, Frateuria, Dyella, Burkholderia-Caballeronia-Paraburkholderia were considered as the most important indigenous atrazine-degrading microorganisms due to their relative abundances were positively correlated with the atrazine degradation rate. In addition, P. ureafaciens ZY also increased the abundance of atrazine-degrading genus Streptomyces and Bacillus, indicating that there may be a synergic relationship between them in the process of atrazine degradation. Our work provides a new insight between inoculums and native microorganisms on the degradation of atrazine.

Joint international consensus statement on crowdsourcing challenge contests in health and medicine: results of a modified Delphi process.

OBJECTIVES: To develop a consensus statement to provide advice on designing, implementing and evaluating crowdsourcing challenge contests in public health and medical contexts. DESIGN: Modified Delphi using three rounds of survey questionnaires and one consensus workshop. SETTING: Uganda for face-to-face consensus activities, global for online survey questionnaires. PARTICIPANTS: A multidisciplinary expert panel was convened at a consensus-development conference in Uganda and included 21 researchers with experience leading challenge contests, five public health sector workers, and nine Ugandan end users. An online survey was sent to 140 corresponding authors of previously published articles that had used crowdsourcing methods. RESULTS: A subgroup of expert panel members developed the initial statement and survey. We received responses from 120 (85.7%) survey participants, which were presented at an in-person workshop of all 21 panel members. Panelists discussed each of the sections, revised the statement, and participated in a second round of the survey questionnaire. Based on this second survey round, we held detailed discussions of each subsection with workshop participants and further revised the consensus statement. We then conducted the third round of the questionnaire among the 21 expert panelists and used the results to finalize the statement. This iterative process resulted in 23 final statement items, all with greater than 80% consensus. Statement items are organised into the seven stages of a challenge contest, including the following: considering the appropriateness, organising a community steering committee, promoting the contest, assessing contributions, recognising contributors, sharing ideas and evaluating the contest (COPARSE). CONCLUSIONS: There is high agreement among crowdsourcing experts and stakeholders on the design and implementation of crowdsourcing challenge contests. The COPARSE consensus statement can be used to organise crowdsourcing challenge contests, improve the rigour and reproducibility of crowdsourcing research and enable large-scale collaboration.

Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study.

BACKGROUND: The association of early-life undernutrition and dyslipidemia found in previous studies may be confounded by the uncontrolled age difference between exposed and unexposed participants. The study aimed to investigate the association of early-life undernutrition and the risk of dyslipidemia in adulthood with good control of the age variable. METHODS: We took the Great Chinese Famine (1959-1961) as a natural experiment of severe undernutrition. This study was based on the baseline investigation of a population-based cohort in rural China. Undernutrition in early life was defined as being exposed to famine at younger than 3 years of age. Three approaches including Adjustment, Restriction, and Matching were applied to control the confounding effect of age. Logistic regression models were applied to evaluate the association between early-life famine and the presence of dyslipidemia. Stratified analysis by gender was also performed, and potential effect modification was tested by adding the interaction term of the famine exposure variable and gender into the model. RESULTS: Undernutrition in early life was associated with increased risk of borderline high and above (BHA) levels of total cholesterol (TC, ORAdjustment = 1.61; ORRestriction = 1.56; ORMatching = 1.87), triglycerides (TG, ORAdjustment = 1.33; ORRestriction = 1.30; ORMatching = 1.34), low-density lipoprotein cholesterol (LDL-C, ORAdjustment = 1.75; ORRestriction = 1.53; ORMatching = 1.77) and dyslipidemia (ORAdjustment = 1.52; ORRestriction = 1.45; ORMatching = 1.60), as well as high levels of TC, TG, LDL-C and dyslipidemia. An inverse association of undernutrition and risk of low high-density lipoprotein cholesterol (HDL-C) was found. Female participants with undernutrition experience had an increased risk of BHA TG and LDL-C (TG: ORAdjustment, female = 1.45; ORRestriction, female = 1.39; ORMatching, female = 1.51; LDL-C: ORAdjustment, female = 2.11; ORRestriction, female = 1.80; ORMatching, female = 2.15), but this association was not found in males. CONCLUSION: Early-life undernutrition increased the risk of TC, TG, LDL-C, and dyslipidemia. Gender would significantly modify this effect for TG and LDL-C. These results emphasize the importance of nutritional conditions in the early stages of life to long-term health consequences.

A Global Crowdsourcing Open Call to Improve Research Mentorship in Low- and Middle-Income Countries: A Mixed Methods Analysis.

Research mentoring programs are limited in many low- and middle-income countries (LMICs). The TDR Global initiated a global crowdsourcing open call soliciting proposals on how to improve research mentorship in LMICs. The purpose of this study is to examine ideas submitted to this open call to identify the ways to improve research mentorship in LMICs. Open calls have a group of individuals solve all or part of a problem and then share solutions. A WHO/TDR/SESH crowdsourcing guide was used to structure the open call. Each submission was judged by three independent individuals on a 1-10 scale. Textual submissions were extracted from eligible proposals and qualitatively analyzed via inductive and deductive coding techniques to identify themes. The open call received 123 submissions from 40 countries in Asia (49), Africa (38), Latin America (26), and Europe (10). Among all participants, 108 (87%) had research experience. A total of 21 submissions received a mean score of 7/10 or higher. Our thematic analysis identified three overarching themes related to prementoring, facilitation, and evaluation. Prementoring establishes mentor-mentee compatibility to lay foundations for mentorship. Facilitation involves iterative cycles of planning, communication, and skill improvement. Evaluation creates commitment and accountability within a framework of monitoring. This global crowdsourcing open call generated numerous mentorship ideas, including LMIC-contextualized facilitation tools. The open call demonstrates a need for greater focus on mentorship. Our data may inform the development of formal and informal mentoring programs in LMIC settings.