ABSTRACT
An unprecedented zeolite supramolecular framework featuring truncated cuboctahedral and truncated octahedral cavities was self-assembled from tetrahedral metal-organic cationic cages and tetrahedral anions. This crystalline porous material could trap iodine and organic dye molecules, and its solid state spin-crossover behavior was affected by guest encapsulation.
ABSTRACT
Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-ß (Aß) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral Aß inhibitors using supramolecular metal-organic cages.
Subject(s)
Amyloid beta-Peptides/antagonists & inhibitors , Macromolecular Substances/pharmacology , Metal-Organic Frameworks/pharmacology , Protein Aggregates/drug effects , Amyloid beta-Peptides/metabolism , Crystallography, X-Ray , Humans , Macromolecular Substances/chemistry , Metal-Organic Frameworks/chemistry , Models, Molecular , Molecular Conformation/drug effectsABSTRACT
Four pairs of enantiomers of water-stable tetrahedral metal-organic cages [Ni4L6](8+) were facilely synthesized. They efficiently stabilized antiparallel G-quadruplex DNA with moderate enantioselectivity, and displayed promising cytotoxicity against the human cancer cell lines HCT116, HepG2 and MCF-7. These results provide a new insight into the rational design of chiral G-quadruplex-based anticancer agents.
