ABSTRACT
The pharmacokinetics of PHL-6 and interferon synthesis dynamic in the target organs (tissues) of mice were studied during its and intraperitoneal administration. In the experimental setting, there was a direct correlation between the interferon production in the murine organs with single PHL-6 and distribution of 14C PHL-6. The highest radioactivity with its oral administration was detected in the liver and intestine. Interferon was actively synthesized in the intestine, liver and serum, showing the levels of 20000, 1024-2048 and 512-1024 IU/ml, respectively. The prolonged action of the drug was in good agreement with the low PHL-6 excretion from the body. It was also shown that almost the whole radiation dose 1 (greater than 98%) was excreted with feces and urine after single and chronic administrations of uniformly labeled PHL-6 which proved important clinical drug use.
Subject(s)
Brain/metabolism , Interferon Inducers/pharmacokinetics , Interferons/biosynthesis , Viscera/metabolism , Administration, Oral , Animals , Drug Stability , Injections, Intramuscular , Interferon Inducers/administration & dosage , Male , Mice , Mice, Inbred CBA , Organic ChemicalsABSTRACT
The clastogenic and mutagenic activities of a new antifertility and antitumor agent gossypol were studied in the mouse male germ cells. Results of the present work indicate that at the doses 125 and 250 mg/kg the drug does not significantly increase frequencies of the micronuclei in the early spermatids and sperm head abnormalities. Hence, genotoxic influence can not be proposed as responsible for the antifertility effect of gossypol.
Subject(s)
Gossypol/toxicity , Mutagens , Spermatids/drug effects , Spermatozoa/drug effects , Animals , Cell Nucleus/drug effects , Cell Nucleus/ultrastructure , Male , Mice , Sperm Head/drug effects , Sperm Head/ultrastructure , Spermatids/ultrastructure , Spermatozoa/ultrastructureABSTRACT
This review summarizes the main results of experimental and clinical studies of a new antifertile agent, gossypol, a polyphenolic compound isolated from the cotton. This compound disturb the normal course of spermatogenesis and affects, first of all, the locomotory system of mature spermatozoa of the man and some mammal species. The mechanism of gossypol action on the development of germ cells is discussed. Since the action of gossypol is reversible and it does not induce strong side effects, the possibility of its application for the control of birth rate is considered.
